Project measure / variable:   Auwerx2   vco2_basal_HFD

ID, description, units MPD:114636   vco2_basal_HFD   basal carbon dioxide production, prior to treadmill test   [mL/kg/min]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 19wks
Procedure monitoring system
Ontology mappings

  STRAIN COMPARISON PLOT
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Auwerx2 - basal carbon dioxide production, prior to treadmill test HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means96.54   mL/kg/min 85.28   mL/kg/min
Median of the strain means98.73   mL/kg/min 83.24   mL/kg/min
SD of the strain means± 17.323 ± 14.957
Coefficient of variation (CV)0.1794 0.1754
Min–max range of strain means73.55   –   114.4   mL/kg/min 67.5   –   110.8   mL/kg/min
Mean sample size per strain4.4   mice 3.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 2770.2821 2770.2821 12.9427 0.0007
strain 7 14101.3645 2014.4806 9.4116 < 0.0001
sex:strain 7 632.9699 90.4243 0.4225 0.8837
Residuals 50 10702.0693 214.0414


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 82.41 7.1315   5 3.1893 0.0865 71.5, 89.65 -0.82
129S1/SvImJ m 79.44 4.3911   2   3.105 0.0553 76.34, 82.55 -0.39
A/J f 80.96 7.3849   4 3.6924 0.0912 70.65, 86.83 -0.9
A/J m 68.27 9.5681   5 4.279 0.1402 53.03, 76.37 -1.14
C57BL/6J f 98.73 13.666   3 7.89 0.1384 90.29, 114.5 0.13
C57BL/6J m 83.24 5.5788   3 3.2209 0.067 78.38, 89.33 -0.14
CAST/EiJ f 113.1 23.204   5 10.377 0.2052 88.52, 147.7 0.96
CAST/EiJ m 110.8 2.7577   2   1.95 0.0249 108.9, 112.8 1.71
DBA/2J f 113.7 9.6952   5 4.3358 0.0853 100.2, 126.5 0.99
DBA/2J m 98.8 7.9993   5 3.5774 0.081 90.19, 107.7 0.9
NOD/ShiLtJ f 79.64 11.95   6 4.8785 0.15 64.98, 92.84 -0.98
NOD/ShiLtJ m 67.5 6.2116   5 2.7779 0.092 57.53, 73.43 -1.19
NZO/HlLtJ f 73.55 7.7568   5 3.469 0.1055 63.5, 84.41 -1.33
NZO/HlLtJ m 74.14 0.0   1   0.0 0.0 74.14, 74.14 -0.74
PWK/PhJ f 114.4 27.306   4 13.653 0.2386 88.51, 148.9 1.03
PWK/PhJ m 98.94 9.3905   5 4.1996 0.0949 90.16, 112.0 0.91
WSB/EiJ f 112.4 39.619   3 22.874 0.3526 74.99, 153.9 0.92
WSB/EiJ m 86.37 6.4055   4 3.2027 0.0742 77.03, 91.55 0.07


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 82.41 6.542803471 95.5516075303 69.2683924697
129S1/SvImJ m 79.445 10.3450806256 100.2237059559 58.6662940441
A/J f 80.9625 7.3150766623 95.6552638857 66.2697361143
A/J m 68.268 6.542803471 81.4096075303 55.1263924697
C57BL/6J f 98.7333333333 8.4467229602 115.6990757025 81.7675909642
C57BL/6J m 83.2366666667 8.4467229602 100.2024090358 66.2709242975
CAST/EiJ f 113.072 6.542803471 126.2136075303 99.9303924697
CAST/EiJ m 110.85 10.3450806256 131.6287059559 90.0712940441
DBA/2J f 113.72 6.542803471 126.8616075303 100.5783924697
DBA/2J m 98.796 6.542803471 111.9376075303 85.6543924697
NOD/ShiLtJ f 79.645 5.972735084 91.6415914771 67.6484085229
NOD/ShiLtJ m 67.502 6.542803471 80.6436075303 54.3603924697
PWK/PhJ f 114.43 7.3150766623 129.1227638857 99.7372361143
PWK/PhJ m 98.942 6.542803471 112.0836075303 85.8003924697
WSB/EiJ f 112.3633333333 8.4467229602 129.3290757025 95.3975909642
WSB/EiJ m 86.37 7.3150766623 101.0627638857 71.6772361143


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 80.9275 6.1202322344 93.2203482225 68.6346517775
A/J both 74.61525 4.9071026032 84.4714556478 64.7590443522
C57BL/6J both 90.985 5.972735084 102.9815914771 78.9884085229
CAST/EiJ both 111.961 6.1202322344 124.2538482225 99.6681517775
DBA/2J both 106.258 4.6264607023 115.5505198004 96.9654801996
NOD/ShiLtJ both 73.5735 4.4294988894 82.4704103563 64.6765896437
PWK/PhJ both 106.686 4.9071026032 116.5422056478 96.8297943522
WSB/EiJ both 99.3666666667 5.5869820865 110.5884504457 88.1448828876




  GWAS USING LINEAR MIXED MODELS