Project measure / variable:   Auwerx2   vco2_basal_CD

ID, description, units MPD:114635   vco2_basal_CD   basal carbon dioxide production, prior to treadmill test   [mL/kg/min]  CD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 19wks
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  STRAIN COMPARISON PLOT
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Auwerx2 - basal carbon dioxide production, prior to treadmill test CD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means91.04   mL/kg/min 84.55   mL/kg/min
Median of the strain means88.16   mL/kg/min 79.84   mL/kg/min
SD of the strain means± 20.065 ± 13.206
Coefficient of variation (CV)0.2204 0.1562
Min–max range of strain means68.96   –   128.2   mL/kg/min 65.31   –   104.1   mL/kg/min
Mean sample size per strain4.2   mice 4.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 121.9315 121.9315 0.9686 0.329
strain 7 9381.1142 1340.1592 10.6465 < 0.0001
sex:strain 7 4257.4299 608.2043 4.8317 0.0002
Residuals 59 7426.7961 125.8779


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 72.27 6.5787   5 2.9421 0.091 60.7, 76.4 -0.94
129S1/SvImJ m 79.84 10.186   5 4.5555 0.1276 67.89, 95.96 -0.36
A/J f 68.96 7.7201   4 3.8601 0.1119 62.08, 79.76 -1.1
A/J m 65.31 5.4789   3 3.1632 0.0839 61.76, 71.62 -1.46
C57BL/6J f 91.22 4.528   5 2.025 0.0496 83.78, 94.87 0.01
C57BL/6J m 93.52 16.744   5 7.4881 0.179 77.19, 114.6 0.68
CAST/EiJ f 116.5 0.0   1   0.0 0.0 116.5, 116.5 1.27
CAST/EiJ m 101.4 11.67   3 6.7376 0.1151 90.62, 113.8 1.28
DBA/2J f 88.16 8.1983   5 3.6664 0.093 77.85, 97.11 -0.14
DBA/2J m 104.1 9.2675   5 4.1445 0.089 91.82, 114.7 1.48
NOD/ShiLtJ f 74.17 8.0275   6 3.2772 0.1082 60.69, 84.85 -0.84
NOD/ShiLtJ m 74.39 8.2508   5 3.6899 0.1109 65.01, 84.62 -0.77
NZO/HlLtJ f 84.62 6.9505   4 3.4752 0.0821 77.08, 93.16 -0.32
NZO/HlLtJ m 74.3 2.7555   5 1.2323 0.0371 69.92, 77.25 -0.78
PWK/PhJ f 95.25 5.5643   5 2.4884 0.0584 85.9, 100.1 0.21
PWK/PhJ m 79.19 12.938   5 5.7862 0.1634 58.59, 88.75 -0.41
WSB/EiJ f 128.2 37.296   3 21.533 0.2909 96.76, 169.4 1.85
WSB/EiJ m 88.94 10.473   5 4.6838 0.1178 76.09, 102.9 0.33


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 72.268 5.0175272794 82.3080488956 62.2279511044
129S1/SvImJ m 79.836 5.0175272794 89.8760488956 69.7959511044
A/J f 68.9625 5.6097660379 80.187615914 57.737384086
A/J m 65.31 6.4775998641 78.2716473893 52.3483526107
C57BL/6J f 91.224 5.0175272794 101.2640488956 81.1839511044
C57BL/6J m 93.522 5.0175272794 103.5620488956 83.4819511044
DBA/2J f 88.158 5.0175272794 98.1980488956 78.1179511044
DBA/2J m 104.102 5.0175272794 114.1420488956 94.0619511044
NOD/ShiLtJ f 74.1716666667 4.5803547898 83.336935431 65.0063979024
NOD/ShiLtJ m 74.394 5.0175272794 84.4340488956 64.3539511044
NZO/HlLtJ f 84.6175 5.6097660379 95.842615914 73.392384086
NZO/HlLtJ m 74.304 5.0175272794 84.3440488956 64.2639511044
PWK/PhJ f 95.246 5.0175272794 105.2860488956 85.2059511044
PWK/PhJ m 79.192 5.0175272794 89.2320488956 69.1519511044
WSB/EiJ f 128.1866666667 6.4775998641 141.1483140559 115.2250192774
WSB/EiJ m 88.94 5.0175272794 98.9800488956 78.8999511044


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 76.052 3.5479275641 83.1513866575 68.9526133425
A/J both 67.13625 4.2845295833 75.7095738934 58.5629261066
C57BL/6J both 92.373 3.5479275641 99.4723866575 85.2736133425
DBA/2J both 96.13 3.5479275641 103.2293866575 89.0306133425
NOD/ShiLtJ both 74.2828333333 3.3968820262 81.0799785677 67.485688099
NZO/HlLtJ both 79.46075 3.7631454596 86.9907866717 71.9307133283
PWK/PhJ both 87.219 3.5479275641 94.3183866575 80.1196133425
WSB/EiJ both 108.5633333333 4.0967938684 116.7609989289 100.3656677377




  GWAS USING LINEAR MIXED MODELS