Project measure / variable:   Auwerx2   vo2_basal_CD

ID, description, units MPD:114633   vo2_basal_CD   basal oxygen consumption, prior to treadmill test   [mL/kg/min]  CD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 19wks
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  STRAIN COMPARISON PLOT
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Auwerx2 - basal oxygen consumption, prior to treadmill test CD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means110.4   mL/kg/min 101.0   mL/kg/min
Median of the strain means108.4   mL/kg/min 98.05   mL/kg/min
SD of the strain means± 23.823 ± 15.283
Coefficient of variation (CV)0.2159 0.1513
Min–max range of strain means83.45   –   162.1   mL/kg/min 79.63   –   122.1   mL/kg/min
Mean sample size per strain4.2   mice 4.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 627.9912 627.9912 4.5331 0.0374
strain 7 17238.6449 2462.6636 17.7766 < 0.0001
sex:strain 7 5533.1559 790.4508 5.7058 < 0.0001
Residuals 59 8173.4993 138.5339


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 91.07 7.9476   5 3.5543 0.0873 78.39, 98.81 -0.81
129S1/SvImJ m 98.05 10.725   5 4.7966 0.1094 84.31, 113.4 -0.19
A/J f 83.45 6.8493   4 3.4247 0.0821 77.74, 92.06 -1.13
A/J m 79.63 5.9133   3 3.414 0.0743 75.14, 86.33 -1.4
C57BL/6J f 115.0 4.6586   5 2.0834 0.0405 109.6, 120.5 0.19
C57BL/6J m 113.0 16.704   5 7.4703 0.1479 93.04, 130.5 0.78
CAST/EiJ f 124.2 0.0   1   0.0 0.0 124.2, 124.2 0.58
CAST/EiJ m 114.8 9.5422   3 5.5092 0.0831 106.7, 125.3 0.9
DBA/2J f 108.4 8.2875   5 3.7063 0.0765 99.0, 118.2 -0.08
DBA/2J m 122.1 12.12   5 5.4201 0.0992 104.9, 133.6 1.38
NOD/ShiLtJ f 90.27 9.7927   6 3.9979 0.1085 76.78, 101.5 -0.84
NOD/ShiLtJ m 84.67 7.4878   5 3.3486 0.0884 76.38, 95.48 -1.07
NZO/HlLtJ f 100.9 8.2884   4 4.1442 0.0821 89.43, 108.7 -0.4
NZO/HlLtJ m 87.11 2.4825   5 1.1102 0.0285 84.19, 89.41 -0.91
PWK/PhJ f 117.9 5.7609   5 2.5764 0.0489 108.8, 124.7 0.32
PWK/PhJ m 96.8 14.377   5 6.4295 0.1485 72.96, 108.0 -0.28
WSB/EiJ f 162.1 36.028   3 20.801 0.2223 132.2, 202.1 2.17
WSB/EiJ m 113.1 13.18   5 5.8941 0.1165 96.75, 133.2 0.79


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 91.068 5.2637227653 101.600684925 80.535315075
129S1/SvImJ m 98.048 5.2637227653 108.580684925 87.515315075
A/J f 83.45 5.885020959 95.2258997389 71.6741002611
A/J m 79.63 6.7954368697 93.2276377684 66.0323622316
C57BL/6J f 114.96 5.2637227653 125.492684925 104.427315075
C57BL/6J m 112.968 5.2637227653 123.500684925 102.435315075
DBA/2J f 108.38 5.2637227653 118.912684925 97.847315075
DBA/2J m 122.12 5.2637227653 132.652684925 111.587315075
NOD/ShiLtJ f 90.2716666667 4.8050994917 99.8866485408 80.6566847925
NOD/ShiLtJ m 84.672 5.2637227653 95.204684925 74.139315075
NZO/HlLtJ f 100.9075 5.885020959 112.6833997389 89.1316002611
NZO/HlLtJ m 87.106 5.2637227653 97.638684925 76.573315075
PWK/PhJ f 117.86 5.2637227653 128.392684925 107.327315075
PWK/PhJ m 96.796 5.2637227653 107.328684925 86.263315075
WSB/EiJ f 162.1 6.7954368697 175.6976377684 148.5023622316
WSB/EiJ m 113.09 5.2637227653 123.622684925 102.557315075


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 94.558 3.7220140617 102.0057329345 87.1102670655
A/J both 81.54 4.4947590018 90.5339919883 72.5460080117
C57BL/6J both 113.964 3.7220140617 121.4117329345 106.5162670655
DBA/2J both 115.25 3.7220140617 122.6977329345 107.8022670655
NOD/ShiLtJ both 87.4718333333 3.5635571581 94.6024947362 80.3411719305
NZO/HlLtJ both 94.00675 3.947792074 101.9062636937 86.1072363063
PWK/PhJ both 107.328 3.7220140617 114.7757329345 99.8802670655
WSB/EiJ both 137.595 4.2978116408 146.1949012292 128.9950987708




  GWAS USING LINEAR MIXED MODELS