Project measure / variable:   Auwerx2   vco2_night_HFD

ID, description, units MPD:114576   vco2_night_HFD   carbon dioxide production, 24h test, night time average   [mL/kg/min]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 14wks
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  STRAIN COMPARISON PLOT
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Auwerx2 - carbon dioxide production, 24h test, night time average HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means4213.0   mL/kg/min 3594.0   mL/kg/min
Median of the strain means4219.0   mL/kg/min 3351.0   mL/kg/min
SD of the strain means± 866.8 ± 861.0
Coefficient of variation (CV)0.2058 0.2396
Min–max range of strain means2776.0   –   5446.0   mL/kg/min 2435.0   –   4983.0   mL/kg/min
Mean sample size per strain4.4   mice 3.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 5950679.7067 5950679.7067 43.8734 < 0.0001
strain 7 34297315.822 4899616.546 36.1241 < 0.0001
sex:strain 7 3506142.836 500877.548 3.6929 0.0026
Residuals 52 7052918.4 135633.0462


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 3763.0 433.4   5 193.8 0.1152 3248.0, 4440.0 -0.52
129S1/SvImJ m 3351.0 2.8284   2   2.0 0.0008 3349.0, 3353.0 -0.28
A/J f 3866.0 178.1   4 89.06 0.0461 3649.0, 4054.0 -0.4
A/J m 2858.0 129.6   5 57.94 0.0453 2670.0, 3010.0 -0.85
C57BL/6J f 4479.0 149.5   3 86.31 0.0334 4365.0, 4648.0 0.31
C57BL/6J m 3118.0 157.5   4 78.75 0.0505 2893.0, 3249.0 -0.55
CAST/EiJ f 5289.0 607.5   5 271.7 0.1149 4713.0, 6304.0 1.24
CAST/EiJ m 4366.0 481.5   2   340.5 0.1103 4026.0, 4707.0 0.9
DBA/2J f 4219.0 444.2   5 198.6 0.1053 3666.0, 4886.0 0.01
DBA/2J m 3528.0 88.57   5 39.61 0.0251 3422.0, 3660.0 -0.08
NOD/ShiLtJ f 3401.0 316.5   6 129.2 0.0931 3131.0, 3961.0 -0.94
NOD/ShiLtJ m 3112.0 200.0   5 89.43 0.0643 2920.0, 3400.0 -0.56
NZO/HlLtJ f 2776.0 200.7   5 89.75 0.0723 2428.0, 2945.0 -1.66
NZO/HlLtJ m 2435.0 0.0   1   0.0 0.0 2435.0, 2435.0 -1.35
PWK/PhJ f 5446.0 370.0   4 185.0 0.0679 5059.0, 5917.0 1.42
PWK/PhJ m 4593.0 331.9   5 148.4 0.0723 4042.0, 4894.0 1.16
WSB/EiJ f 4676.0 799.4   3 461.6 0.171 3762.0, 5245.0 0.53
WSB/EiJ m 4983.0 418.7   5 187.2 0.084 4261.0, 5338.0 1.61


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 3762.6 164.701576285 4093.097891841 3432.1021081591
129S1/SvImJ m 3351.0 260.4160576403 3873.5630500507 2828.4369499493
A/J f 3866.0 184.1419602873 4235.5078762884 3496.4921237116
A/J m 2858.0 164.701576285 3188.497891841 2527.502108159
C57BL/6J f 4478.6666666667 212.628820682 4905.3376103522 4051.9957229811
C57BL/6J m 3118.25 184.1419602873 3487.7578762884 2748.7421237116
CAST/EiJ f 5288.6 164.701576285 5619.097891841 4958.102108159
CAST/EiJ m 4366.5 260.4160576403 4889.0630500507 3843.9369499493
DBA/2J f 4219.2 164.701576285 4549.697891841 3888.702108159
DBA/2J m 3528.4 164.701576285 3858.897891841 3197.902108159
NOD/ShiLtJ f 3400.6666666667 150.3512809799 3702.368584282 3098.9647490513
NOD/ShiLtJ m 3112.0 164.701576285 3442.497891841 2781.502108159
PWK/PhJ f 5446.25 184.1419602873 5815.7578762884 5076.7421237116
PWK/PhJ m 4592.8 164.701576285 4923.297891841 4262.302108159
WSB/EiJ f 4676.0 212.628820682 5102.6709436856 4249.3290563144
WSB/EiJ m 4983.4 164.701576285 5313.897891841 4652.902108159


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 3556.8 154.06421738 3865.95246958 3247.64753042
A/J both 3362.0 123.5261822138 3609.8734188807 3114.1265811193
C57BL/6J both 3798.4583333333 140.6407452724 4080.6746354956 3516.242031171
CAST/EiJ both 4827.55 154.06421738 5136.70246958 4518.39753042
DBA/2J both 3873.8 116.4616014632 4107.4973004886 3640.1026995114
NOD/ShiLtJ both 3256.3333333333 111.5034942536 3480.0814638306 3032.5852028361
PWK/PhJ both 5019.525 123.5261822138 5267.3984188807 4771.6515811193
WSB/EiJ both 4829.7 134.4782739101 5099.550398692 4559.849601308




  GWAS USING LINEAR MIXED MODELS