Project measure / variable:   Auwerx2   vco2_day_HFD

ID, description, units MPD:114574   vco2_day_HFD   carbon dioxide production, 24h test, day time average   [mL/kg/min]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 14wks
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  STRAIN COMPARISON PLOT
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Auwerx2 - carbon dioxide production, 24h test, day time average HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means3507.0   mL/kg/min 2933.0   mL/kg/min
Median of the strain means3418.0   mL/kg/min 2892.0   mL/kg/min
SD of the strain means± 671.3 ± 545.0
Coefficient of variation (CV)0.1914 0.1858
Min–max range of strain means2544.0   –   4642.0   mL/kg/min 2084.0   –   3684.0   mL/kg/min
Mean sample size per strain4.4   mice 3.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 5594356.1009 5594356.1009 44.7248 < 0.0001
strain 7 17890901.709 2555843.1013 20.433 < 0.0001
sex:strain 7 1741454.9107 248779.273 1.9889 0.0743
Residuals 52 6504372.75 125084.0913


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 3228.0 263.7   5 117.9 0.0817 2904.0, 3560.0 -0.42
129S1/SvImJ m 2892.0 253.9   2   179.5 0.0878 2712.0, 3071.0 -0.07
A/J f 3370.0 237.3   4 118.7 0.0704 3151.0, 3647.0 -0.2
A/J m 2409.0 181.1   5 80.97 0.0752 2133.0, 2627.0 -0.96
C57BL/6J f 3791.0 95.62   3 55.2 0.0252 3732.0, 3901.0 0.42
C57BL/6J m 2794.0 132.0   4 66.01 0.0472 2597.0, 2876.0 -0.25
CAST/EiJ f 4642.0 663.1   5 296.5 0.1428 4146.0, 5731.0 1.69
CAST/EiJ m 3684.0 351.4   2   248.5 0.0954 3435.0, 3932.0 1.38
DBA/2J f 3418.0 270.3   5 120.9 0.0791 3104.0, 3800.0 -0.13
DBA/2J m 2950.0 223.5   5 99.96 0.0758 2640.0, 3144.0 0.03
NOD/ShiLtJ f 2654.0 200.4   6 81.83 0.0755 2477.0, 3029.0 -1.27
NOD/ShiLtJ m 2566.0 215.9   5 96.57 0.0842 2249.0, 2857.0 -0.67
NZO/HlLtJ f 2544.0 122.5   5 54.79 0.0481 2384.0, 2649.0 -1.44
NZO/HlLtJ m 2084.0 0.0   1   0.0 0.0 2084.0, 2084.0 -1.56
PWK/PhJ f 4142.0 378.7   4 189.3 0.0914 3610.0, 4505.0 0.95
PWK/PhJ m 3537.0 352.4   5 157.6 0.0996 2983.0, 3905.0 1.11
WSB/EiJ f 3778.0 850.5   3 491.1 0.2251 3064.0, 4719.0 0.4
WSB/EiJ m 3477.0 404.9   5 181.1 0.1164 3092.0, 3956.0 1.0


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 3228.0 158.1670581039 3545.3854218101 2910.6145781899
129S1/SvImJ m 2891.5 250.0840772082 3393.3304145266 2389.6695854734
A/J f 3370.0 176.8361468607 3724.8476891174 3015.1523108826
A/J m 2409.0 158.1670581039 2726.3854218101 2091.6145781899
C57BL/6J f 3790.6666666667 204.192793985 4200.4094843332 3380.9238490001
C57BL/6J m 2794.25 176.8361468607 3149.0976891174 2439.4023108826
CAST/EiJ f 4641.8 158.1670581039 4959.1854218101 4324.4145781899
CAST/EiJ m 3683.5 250.0840772082 4185.3304145266 3181.6695854734
DBA/2J f 3417.6 158.1670581039 3734.9854218101 3100.2145781899
DBA/2J m 2950.4 158.1670581039 3267.7854218101 2633.0145781899
NOD/ShiLtJ f 2653.6666666667 144.3861092962 2943.3985915812 2363.9347417522
NOD/ShiLtJ m 2565.8 158.1670581039 2883.1854218101 2248.4145781899
PWK/PhJ f 4141.5 176.8361468607 4496.3476891174 3786.6523108826
PWK/PhJ m 3537.0 158.1670581039 3854.3854218101 3219.6145781899
WSB/EiJ f 3778.0 204.192793985 4187.7428176665 3368.2571823335
WSB/EiJ m 3477.0 158.1670581039 3794.3854218101 3159.6145781899


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 3059.75 147.9517353247 3356.6368769926 2762.8631230074
A/J both 2889.5 118.6252935779 3127.5390663576 2651.4609336424
C57BL/6J both 3292.4583333333 135.0608380989 3563.4777325935 3021.4389340732
CAST/EiJ both 4162.65 147.9517353247 4459.5368769926 3865.7631230074
DBA/2J both 3184.0 111.8409993456 3408.4253840117 2959.5746159883
NOD/ShiLtJ both 2609.7333333333 107.079604532 2824.6042796548 2394.8623870119
PWK/PhJ both 3839.25 118.6252935779 4077.2890663576 3601.2109336424
WSB/EiJ both 3627.5 129.1428621572 3886.6441117443 3368.3558882557




  GWAS USING LINEAR MIXED MODELS