Project measure / variable:   Auwerx2   vo2_day_HFD

ID, description, units MPD:114570   vo2_day_HFD   oxygen consumption, 24h test, day time average   [mL/kg/min]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 14wks
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  STRAIN COMPARISON PLOT
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Auwerx2 - oxygen consumption, 24h test, day time average HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means4628.0   mL/kg/min 3948.0   mL/kg/min
Median of the strain means4475.0   mL/kg/min 3849.0   mL/kg/min
SD of the strain means± 913.7 ± 674.9
Coefficient of variation (CV)0.1974 0.171
Min–max range of strain means3304.0   –   6176.0   mL/kg/min 2981.0   –   4867.0   mL/kg/min
Mean sample size per strain4.4   mice 3.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 8150730.9626 8150730.9626 40.5471 < 0.0001
strain 7 32456793.5258 4636684.7894 23.0659 < 0.0001
sex:strain 7 2485310.1488 355044.307 1.7662 0.1142
Residuals 52 10452990.5833 201019.0497


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 4243.0 349.2   5 156.2 0.0823 3888.0, 4734.0 -0.42
129S1/SvImJ m 3849.0 322.4   2   228.0 0.0838 3621.0, 4077.0 -0.15
A/J f 4311.0 180.5   4 90.26 0.0419 4131.0, 4502.0 -0.35
A/J m 3294.0 199.9   5 89.39 0.0607 3025.0, 3575.0 -0.97
C57BL/6J f 4909.0 90.67   3 52.35 0.0185 4822.0, 5003.0 0.31
C57BL/6J m 3772.0 231.7   4 115.8 0.0614 3448.0, 3999.0 -0.26
CAST/EiJ f 6176.0 865.0   5 386.8 0.1401 5418.0, 7589.0 1.69
CAST/EiJ m 4794.0 321.7   2   227.5 0.0671 4567.0, 5022.0 1.25
DBA/2J f 4475.0 417.5   5 186.7 0.0933 3865.0, 4864.0 -0.17
DBA/2J m 3852.0 253.1   5 113.2 0.0657 3491.0, 4053.0 -0.14
NOD/ShiLtJ f 3569.0 236.3   6 96.49 0.0662 3289.0, 3966.0 -1.16
NOD/ShiLtJ m 3493.0 259.2   5 115.9 0.0742 3104.0, 3807.0 -0.67
NZO/HlLtJ f 3304.0 166.5   5 74.47 0.0504 3106.0, 3448.0 -1.45
NZO/HlLtJ m 2981.0 0.0   1   0.0 0.0 2981.0, 2981.0 -1.43
PWK/PhJ f 5514.0 495.2   4 247.6 0.0898 4831.0, 6014.0 0.97
PWK/PhJ m 4867.0 516.6   5 231.1 0.1061 4081.0, 5399.0 1.36
WSB/EiJ f 5149.0 1074.0   3 620.0 0.2086 4250.0, 6338.0 0.57
WSB/EiJ m 4629.0 423.9   5 189.6 0.0916 4220.0, 5083.0 1.01


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 4243.4 200.5088774491 4645.7504983197 3841.0495016803
129S1/SvImJ m 3849.0 317.0323719114 4485.1719961971 3212.8280038029
A/J f 4310.75 224.1757400342 4760.5915325119 3860.9084674881
A/J m 3293.8 200.5088774491 3696.1504983197 2891.4495016803
C57BL/6J f 4909.3333333333 258.855847709 5428.7655931102 4389.9010735565
C57BL/6J m 3771.5 224.1757400342 4221.3415325119 3321.6584674881
CAST/EiJ f 6175.6 200.5088774491 6577.9504983197 5773.2495016803
CAST/EiJ m 4794.5 317.0323719114 5430.6719961971 4158.3280038029
DBA/2J f 4474.8 200.5088774491 4877.1504983197 4072.4495016803
DBA/2J m 3851.6 200.5088774491 4253.9504983197 3449.2495016803
NOD/ShiLtJ f 3569.0 183.0387252649 3936.2940732553 3201.7059267447
NOD/ShiLtJ m 3493.4 200.5088774491 3895.7504983197 3091.0495016803
PWK/PhJ f 5514.5 224.1757400342 5964.3415325119 5064.6584674881
PWK/PhJ m 4867.2 200.5088774491 5269.5504983197 4464.8495016803
WSB/EiJ f 5148.6666666667 258.855847709 5668.0989264435 4629.2344068898
WSB/EiJ m 4629.2 200.5088774491 5031.5504983197 4226.8495016803


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 4046.2 187.5588806053 4422.5644285276 3669.8355714724
A/J both 3802.275 150.3816580868 4104.0378737398 3500.5121262602
C57BL/6J both 4340.4166666667 171.2170496132 4683.9888122451 3996.8445210882
CAST/EiJ both 5485.05 187.5588806053 5861.4144285276 5108.6855714724
DBA/2J both 4163.2 141.7811869324 4447.7047657757 3878.6952342243
NOD/ShiLtJ both 3531.2 135.7451517389 3803.5925750395 3258.8074249605
PWK/PhJ both 5190.85 150.3816580868 5492.6128737398 4889.0871262602
WSB/EiJ both 4888.9333333333 163.7148128828 5217.451139546 4560.4155271207




  GWAS USING LINEAR MIXED MODELS