Project measure / variable:   Schoonjans1   bMCA_feces_CD

ID, description, units MPD:112762   bMCA_feces_CD   bile acid β-muricholic acid amount in feces, at 24 wks   [ng/mL]  CD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 24wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - bile acid β-muricholic acid amount in feces, at 24 wks CD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means8.5229   ng/mL
Median of the strain means7.4851   ng/mL
SD of the strain means± 4.5402
Coefficient of variation (CV)0.5327
Min–max range of strain means1.5704   –   24.167   ng/mL
Mean sample size per strain4.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 3508.0516 100.23 4.7569 < 0.0001
Residuals 139 2928.7776 21.0703


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 6.241 2.5048   5 1.1202 0.4013 3.3186, 10.209 -0.5
BXD100 m 7.2238 2.2977   5 1.0275 0.3181 4.6779, 9.4683 -0.29
BXD11 m 10.966 4.228   4 2.114 0.3855 5.3262, 15.405 0.54
BXD12 m 7.472 7.3937   4 3.6968 0.9895 3.2937, 18.52 -0.23
BXD27 m 14.893 8.4122   4 4.2061 0.5648 8.9366, 27.313 1.4
BXD32 m 13.327 16.063   4 8.0316 1.2053 4.5367, 37.407 1.06
BXD34 m 2.2919 0.35016   4 0.17508 0.1528 1.7708, 2.5277 -1.37
BXD39 m 3.204 0.96793   5 0.43287 0.3021 1.6386, 4.1547 -1.17
BXD40 m 2.8741 1.1713   5 0.52381 0.4075 1.4076, 4.307 -1.24
BXD43 m 10.154 4.1528   4 2.0764 0.409 4.4761, 13.958 0.36
BXD45 m 5.1713 2.1127   3 1.2198 0.4085 2.7493, 6.6348 -0.74
BXD48 m 6.1416 5.323   5 2.3805 0.8667 1.7727, 14.591 -0.52
BXD48a m 8.5427 1.7835   4 0.89174 0.2088 7.1018, 11.103 0.0
BXD49 m 4.3045 1.6252   5 0.72681 0.3776 2.0289, 5.8551 -0.93
BXD51 m 12.729 3.593   5 1.6068 0.2823 8.7111, 16.869 0.93
BXD53 m 1.5704 0.19972   5 0.08932 0.1272 1.2504, 1.7876 -1.53
BXD55 m 7.5222 1.5258   5 0.68234 0.2028 5.907, 9.9683 -0.22
BXD6 m 6.1946 1.2923   5 0.57795 0.2086 4.6978, 7.5296 -0.51
BXD62 m 24.167 9.5024   5 4.2496 0.3932 9.8726, 35.407 3.45
BXD63 m 6.762 3.7119   5 1.66 0.5489 3.8366, 12.918 -0.39
BXD64 m 6.1038 1.6017   5 0.71632 0.2624 4.6974, 8.871 -0.53
BXD66 m 13.896 4.3163   5 1.9303 0.3106 6.926, 18.55 1.18
BXD67 m 11.531 0.71859   4 0.35929 0.0623 10.613, 12.2 0.66
BXD69 m 6.1597 2.2419   5 1.0026 0.364 3.9754, 9.1567 -0.52
BXD73 m 4.8966 2.0583   5 0.92052 0.4204 1.8395, 7.2342 -0.8
BXD75 m 8.1368 3.2206   5 1.4403 0.3958 3.8155, 11.454 -0.09
BXD77 m 7.5084 3.5092   5 1.5694 0.4674 3.7047, 12.321 -0.22
BXD79 m 6.4732 2.0048   5 0.89656 0.3097 4.1946, 8.4218 -0.45
BXD8 m 5.9171 1.7758   5 0.79418 0.3001 3.5435, 7.5583 -0.57
BXD81 m 9.0121 3.6396   5 1.6277 0.4039 5.1599, 13.086 0.11
BXD84 m 12.473 3.3483   5 1.4974 0.2684 9.0475, 17.182 0.87
BXD87 m 7.4981 2.0974   5 0.93797 0.2797 5.4679, 10.904 -0.23
BXD89 m 10.778 3.7589   5 1.681 0.3488 8.0487, 17.328 0.5
BXD90 m 12.749 6.3684   5 2.848 0.4995 5.7779, 23.177 0.93
C57BL/6J m 5.4632 2.2354   10 0.7069 0.4092 3.2345, 10.066 -0.67
DBA/2J m 16.478 9.6021   5 4.2942 0.5827 6.3943, 27.166 1.75


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 6.24102 2.0528196607 10.2998093056 2.1822306944
BXD100 m 7.22382 2.0528196607 11.2826093056 3.1650306944
BXD11 m 10.9663 2.2951221535 15.5041643968 6.4284356032
BXD12 m 7.472 2.2951221535 12.0098643968 2.9341356032
BXD27 m 14.8929 2.2951221535 19.4307643968 10.3550356032
BXD32 m 13.326675 2.2951221535 17.8645393968 8.7888106032
BXD34 m 2.291875 2.2951221535 6.8297393968 -2.2459893968
BXD39 m 3.20396 2.0528196607 7.2627493056 -0.8548293056
BXD40 m 2.87412 2.0528196607 6.9329093056 -1.1846693056
BXD43 m 10.1542 2.2951221535 14.6920643968 5.6163356032
BXD45 m 5.1713333333 2.6501787862 10.4112077954 -0.0685411287
BXD48 m 6.14158 2.0528196607 10.2003693056 2.0827906944
BXD48a m 8.5427 2.2951221535 13.0805643968 4.0048356032
BXD49 m 4.30446 2.0528196607 8.3632493056 0.2456706944
BXD51 m 12.72884 2.0528196607 16.7876293056 8.6700506944
BXD53 m 1.57036 2.0528196607 5.6291493056 -2.4884293056
BXD55 m 7.52222 2.0528196607 11.5810093056 3.4634306944
BXD6 m 6.19458 2.0528196607 10.2533693056 2.1357906944
BXD62 m 24.16652 2.0528196607 28.2253093056 20.1077306944
BXD63 m 6.76198 2.0528196607 10.8207693056 2.7031906944
BXD64 m 6.10378 2.0528196607 10.1625693056 2.0449906944
BXD66 m 13.896 2.0528196607 17.9547893056 9.8372106944
BXD67 m 11.531 2.2951221535 16.0688643968 6.9931356032
BXD69 m 6.15972 2.0528196607 10.2185093056 2.1009306944
BXD73 m 4.89658 2.0528196607 8.9553693056 0.8377906944
BXD75 m 8.13682 2.0528196607 12.1956093056 4.0780306944
BXD77 m 7.50838 2.0528196607 11.5671693056 3.4495906944
BXD79 m 6.47316 2.0528196607 10.5319493056 2.4143706944
BXD8 m 5.9171 2.0528196607 9.9758893056 1.8583106944
BXD81 m 9.0121 2.0528196607 13.0708893056 4.9533106944
BXD84 m 12.47318 2.0528196607 16.5319693056 8.4143906944
BXD87 m 7.4981 2.0528196607 11.5568893056 3.4393106944
BXD89 m 10.77756 2.0528196607 14.8363493056 6.7187706944
BXD90 m 12.74898 2.0528196607 16.8077693056 8.6901906944
C57BL/6J m 5.46324 1.4515627026 8.3332374414 2.5932425586
DBA/2J m 16.47754 2.0528196607 20.5363293056 12.4187506944




  GWAS USING LINEAR MIXED MODELS