ITP survival analysis: ursodeoxycholic acid
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
UDCA effect on survival,
females, test site = All
Log-rank test
chisq = 0.1267
p = 0.7219
Wang-Allison test
odds ratio = 1.2856
p = 0.4912
Quantiles
UDCA
Control
% difference
25% died before day:
710
771
-8 %
Median lifespan (days)
882
873
+1 %
75% died before day:
1009
985
+2 %
90% died before day:
1107
1089
+2 %
Max lifespan observed (days)
1225
1456
Number of mice at start
133
281
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
UDCA effect on survival,
males, test site = All
Log-rank test
chisq = 0.5766
p = 0.4477
Wang-Allison test
odds ratio = 1.0991
p = 0.8679
Quantiles
UDCA
Control
% difference
25% died before day:
650
595
+9 %
Median lifespan (days)
839
783
+7 %
75% died before day:
945
921
+3 %
90% died before day:
1064
1057
+1 %
Max lifespan observed (days)
1153
1258
Number of mice at start
149
294
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
UDCA effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.1544
p = 0.6944
Wang-Allison test
odds ratio = 1.0118
p = 1.0
Quantiles
UDCA
Control
% difference
25% died before day:
805
788
+2 %
Median lifespan (days)
913
892
+2 %
75% died before day:
1045
1015
+3 %
90% died before day:
1107
1106
0 %
Max lifespan observed (days)
1208
1267
Number of mice at start
47
95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
UDCA effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.2809
p = 0.5961
Wang-Allison test
odds ratio = 1.1365
p = 0.7888
Quantiles
UDCA
Control
% difference
25% died before day:
648
587
+10 %
Median lifespan (days)
864
763
+13 %
75% died before day:
951
886
+7 %
90% died before day:
1067
1057
+1 %
Max lifespan observed (days)
1128
1258
Number of mice at start
54
101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
UDCA effect on survival,
females, test site = UM
Log-rank test
chisq = 0.5949
p = 0.4405
Wang-Allison test
odds ratio = 1.2888
p = 0.7611
Quantiles
UDCA
Control
% difference
25% died before day:
710
750
-5 %
Median lifespan (days)
819
872
-6 %
75% died before day:
932
979
-5 %
90% died before day:
1110
1081
+3 %
Max lifespan observed (days)
1225
1456
Number of mice at start
42
95
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
UDCA effect on survival,
males, test site = UM
Log-rank test
chisq = 0.5482
p = 0.459
Wang-Allison test
odds ratio = 0.5543
p = 0.5478
Quantiles
UDCA
Control
% difference
25% died before day:
622
712
-13 %
Median lifespan (days)
844
860
-2 %
75% died before day:
1000
983
+2 %
90% died before day:
1088
1121
-3 %
Max lifespan observed (days)
1153
1251
Number of mice at start
44
94
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
UDCA effect on survival,
females, test site = UT
Log-rank test
chisq = 0.0795
p = 0.778
Wang-Allison test
odds ratio = 1.6318
p = 0.3835
Quantiles
UDCA
Control
% difference
25% died before day:
668
754
-11 %
Median lifespan (days)
862
857
+1 %
75% died before day:
1004
977
+3 %
90% died before day:
1097
1089
+1 %
Max lifespan observed (days)
1141
1301
Number of mice at start
44
91
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
UDCA effect on survival,
males, test site = UT
Log-rank test
chisq = 1.9325
p = 0.1645
Wang-Allison test
odds ratio = 1.8021
p = 0.3887
Quantiles
UDCA
Control
% difference
25% died before day:
663
542
+22 %
Median lifespan (days)
789
715
+10 %
75% died before day:
921
857
+7 %
90% died before day:
1034
1013
+2 %
Max lifespan observed (days)
1126
1186
Number of mice at start
51
99
Animal censor events are denoted by + marks in the plot
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ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions