ITP survival analysis:   rapamycin

Intervention:   rapamycin     mTOR complex repressor, anti-aging
Trial code: Rapa Dose: 14 ppm initiated at age: 9 mo Sex: both Cohort: C2006
This compound had a significant effect on survival:   both sexes p < 0.0001

Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
Rapa effect on survival, females, test site = All
Log-rank test chisq = 66.9263 p < 0.0001
Wang-Allison test odds ratio = 12.4791 p < 0.0001
Quantiles Rapa Control % difference
25% died before day: 906 772 +17 %
Median lifespan (days) 1036 882 +17 %
75% died before day: 1182 968 +22 %
90% died before day: 1246 1077 +16 %
Max lifespan observed (days) 1354 1261
Number of mice at start 130 237
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Rapa effect on survival, males, test site = All
Log-rank test chisq = 25.2638 p < 0.0001
Wang-Allison test odds ratio = 4.758 p < 0.0001
Quantiles Rapa Control % difference
25% died before day: 692 650 +6 %
Median lifespan (days) 888 826 +8 %
75% died before day: 1073 949 +13 %
90% died before day: 1178 1060 +11 %
Max lifespan observed (days) 1380 1268
Number of mice at start 145 309
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
Rapa effect on survival, females, test site = TJL
Log-rank test chisq = 23.6005 p < 0.0001
Wang-Allison test odds ratio = 8.7546 p = 0.0033
Quantiles Rapa Control % difference
25% died before day: 930 792 +17 %
Median lifespan (days) 1077 888 +21 %
75% died before day: 1190 972 +22 %
90% died before day: 1290 1077 +20 %
Max lifespan observed (days) 1354 1261
Number of mice at start 47 68
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
Rapa effect on survival, males, test site = TJL
Log-rank test chisq = 6.41 p = 0.0113
Wang-Allison test odds ratio = 5.8018 p = 0.0021
Quantiles Rapa Control % difference
25% died before day: 668 633 +6 %
Median lifespan (days) 841 800 +5 %
75% died before day: 1047 916 +14 %
90% died before day: 1167 1007 +16 %
Max lifespan observed (days) 1380 1197
Number of mice at start 59 96
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
Rapa effect on survival, females, test site = UM
Log-rank test chisq = 18.9287 p < 0.0001
Wang-Allison test odds ratio = 14.6749 p < 0.0001
Quantiles Rapa Control % difference
25% died before day: 884 788 +12 %
Median lifespan (days) 1008 891 +13 %
75% died before day: 1179 990 +19 %
90% died before day: 1237 1069 +16 %
Max lifespan observed (days) 1288 1248
Number of mice at start 46 87
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
Rapa effect on survival, males, test site = UM
Log-rank test chisq = 8.3011 p = 0.004
Wang-Allison test odds ratio = 6.0903 p = 0.0015
Quantiles Rapa Control % difference
25% died before day: 697 701 -1 %
Median lifespan (days) 932 851 +10 %
75% died before day: 1127 974 +16 %
90% died before day: 1195 1077 +11 %
Max lifespan observed (days) 1306 1268
Number of mice at start 43 107
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
Rapa effect on survival, females, test site = UT
Log-rank test chisq = 25.0507 p < 0.0001
Wang-Allison test odds ratio = 14.428 p < 0.0001
Quantiles Rapa Control % difference
25% died before day: 906 748 +21 %
Median lifespan (days) 1006 843 +19 %
75% died before day: 1173 964 +22 %
90% died before day: 1243 1105 +12 %
Max lifespan observed (days) 1259 1192
Number of mice at start 37 82
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
Rapa effect on survival, males, test site = UT
Log-rank test chisq = 10.8655 p = 0.001
Wang-Allison test odds ratio = 3.2031 p = 0.0367
Quantiles Rapa Control % difference
25% died before day: 731 586 +25 %
Median lifespan (days) 888 813 +9 %
75% died before day: 1103 935 +18 %
90% died before day: 1170 1053 +11 %
Max lifespan observed (days) 1271 1212
Number of mice at start 43 106
Animal censor events are denoted by + marks in the plot


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Statistical definitions