ITP survival analysis: rapamycin
This compound had a significant effect on survival: both sexes p < 0.0001
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
Rapa effect on survival,
females, test site = All
Log-rank test
chisq = 66.9263
p < 0.0001
Wang-Allison test
odds ratio = 12.4791
p < 0.0001
Quantiles
Rapa
Control
% difference
25% died before day:
906
772
+17 %
Median lifespan (days)
1036
882
+17 %
75% died before day:
1182
968
+22 %
90% died before day:
1246
1077
+16 %
Max lifespan observed (days)
1354
1261
Number of mice at start
130
237
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
Rapa effect on survival,
males, test site = All
Log-rank test
chisq = 25.2638
p < 0.0001
Wang-Allison test
odds ratio = 4.758
p < 0.0001
Quantiles
Rapa
Control
% difference
25% died before day:
692
650
+6 %
Median lifespan (days)
888
826
+8 %
75% died before day:
1073
949
+13 %
90% died before day:
1178
1060
+11 %
Max lifespan observed (days)
1380
1268
Number of mice at start
145
309
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
Rapa effect on survival,
females, test site = TJL
Log-rank test
chisq = 23.6005
p < 0.0001
Wang-Allison test
odds ratio = 8.7546
p = 0.0033
Quantiles
Rapa
Control
% difference
25% died before day:
930
792
+17 %
Median lifespan (days)
1077
888
+21 %
75% died before day:
1190
972
+22 %
90% died before day:
1290
1077
+20 %
Max lifespan observed (days)
1354
1261
Number of mice at start
47
68
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
Rapa effect on survival,
males, test site = TJL
Log-rank test
chisq = 6.41
p = 0.0113
Wang-Allison test
odds ratio = 5.8018
p = 0.0021
Quantiles
Rapa
Control
% difference
25% died before day:
668
633
+6 %
Median lifespan (days)
841
800
+5 %
75% died before day:
1047
916
+14 %
90% died before day:
1167
1007
+16 %
Max lifespan observed (days)
1380
1197
Number of mice at start
59
96
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
Rapa effect on survival,
females, test site = UM
Log-rank test
chisq = 18.9287
p < 0.0001
Wang-Allison test
odds ratio = 14.6749
p < 0.0001
Quantiles
Rapa
Control
% difference
25% died before day:
884
788
+12 %
Median lifespan (days)
1008
891
+13 %
75% died before day:
1179
990
+19 %
90% died before day:
1237
1069
+16 %
Max lifespan observed (days)
1288
1248
Number of mice at start
46
87
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
Rapa effect on survival,
males, test site = UM
Log-rank test
chisq = 8.3011
p = 0.004
Wang-Allison test
odds ratio = 6.0903
p = 0.0015
Quantiles
Rapa
Control
% difference
25% died before day:
697
701
-1 %
Median lifespan (days)
932
851
+10 %
75% died before day:
1127
974
+16 %
90% died before day:
1195
1077
+11 %
Max lifespan observed (days)
1306
1268
Number of mice at start
43
107
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
Rapa effect on survival,
females, test site = UT
Log-rank test
chisq = 25.0507
p < 0.0001
Wang-Allison test
odds ratio = 14.428
p < 0.0001
Quantiles
Rapa
Control
% difference
25% died before day:
906
748
+21 %
Median lifespan (days)
1006
843
+19 %
75% died before day:
1173
964
+22 %
90% died before day:
1243
1105
+12 %
Max lifespan observed (days)
1259
1192
Number of mice at start
37
82
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
Rapa effect on survival,
males, test site = UT
Log-rank test
chisq = 10.8655
p = 0.001
Wang-Allison test
odds ratio = 3.2031
p = 0.0367
Quantiles
Rapa
Control
% difference
25% died before day:
731
586
+25 %
Median lifespan (days)
888
813
+9 %
75% died before day:
1103
935
+18 %
90% died before day:
1170
1053
+11 %
Max lifespan observed (days)
1271
1212
Number of mice at start
43
106
Animal censor events are denoted by + marks in the plot
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ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions