ITP survival analysis: PB125
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
PB125 effect on survival,
females, test site = All
Log-rank test
chisq = 1.9898
p = 0.1584
Wang-Allison test
odds ratio = 1.4401
p = 0.2908
Quantiles
PB125
Control
% difference
25% died before day:
725
767
-5 %
Median lifespan (days)
874
868
+1 %
75% died before day:
1016
958
+6 %
90% died before day:
1094
1060
+3 %
Max lifespan observed (days)
1256
1221
Number of mice at start
128
276
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
PB125 effect on survival,
males, test site = All
Log-rank test
chisq = 0.2239
p = 0.6361
Wang-Allison test
odds ratio = 1.4219
p = 0.3126
Quantiles
PB125
Control
% difference
25% died before day:
494
447
+11 %
Median lifespan (days)
698
718
-3 %
75% died before day:
876
919
-5 %
90% died before day:
1053
1029
+2 %
Max lifespan observed (days)
1230
1258
Number of mice at start
144
285
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
PB125 effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.917
p = 0.3383
Wang-Allison test
odds ratio = 1.3778
p = 0.5725
Quantiles
PB125
Control
% difference
25% died before day:
710
760
-7 %
Median lifespan (days)
895
870
+3 %
75% died before day:
1018
968
+5 %
90% died before day:
1097
1068
+3 %
Max lifespan observed (days)
1256
1209
Number of mice at start
48
96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
PB125 effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.6566
p = 0.4178
Wang-Allison test
odds ratio = 0.6401
p = 0.5807
Quantiles
PB125
Control
% difference
25% died before day:
435
488
-11 %
Median lifespan (days)
609
748
-19 %
75% died before day:
835
949
-12 %
90% died before day:
1053
1079
-2 %
Max lifespan observed (days)
1185
1226
Number of mice at start
51
102
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
PB125 effect on survival,
females, test site = UM
Log-rank test
chisq = 1.2591
p = 0.2618
Wang-Allison test
odds ratio = 0.3482
p = 0.2203
Quantiles
PB125
Control
% difference
25% died before day:
732
820
-11 %
Median lifespan (days)
885
902
-2 %
75% died before day:
1012
1000
+1 %
90% died before day:
1056
1098
-4 %
Max lifespan observed (days)
1131
1221
Number of mice at start
44
90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
PB125 effect on survival,
males, test site = UM
Log-rank test
chisq = 0.0
p = 0.9947
Wang-Allison test
odds ratio = 1.9181
p = 0.3484
Quantiles
PB125
Control
% difference
25% died before day:
575
468
+23 %
Median lifespan (days)
731
790
-7 %
75% died before day:
928
933
-1 %
90% died before day:
1053
1019
+3 %
Max lifespan observed (days)
1161
1233
Number of mice at start
42
88
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
PB125 effect on survival,
females, test site = UT
Log-rank test
chisq = 6.5175
p = 0.0107
Wang-Allison test
odds ratio = 4.7842
p = 0.0094
Quantiles
PB125
Control
% difference
25% died before day:
722
696
+4 %
Median lifespan (days)
868
824
+5 %
75% died before day:
1032
937
+10 %
90% died before day:
1124
993
+13 %
Max lifespan observed (days)
1245
1198
Number of mice at start
36
90
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
PB125 effect on survival,
males, test site = UT
Log-rank test
chisq = 2.4336
p = 0.1188
Wang-Allison test
odds ratio = 2.3242
p = 0.1527
Quantiles
PB125
Control
% difference
25% died before day:
535
400
+34 %
Median lifespan (days)
735
676
+9 %
75% died before day:
873
825
+6 %
90% died before day:
1053
963
+9 %
Max lifespan observed (days)
1230
1258
Number of mice at start
51
95
Animal censor events are denoted by + marks in the plot
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National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions