ITP survival analysis:   metformin and rapamycin

Intervention:   metformin and rapamycin    
Trial code: MetRapa Dose: Met:1000 ppm and Rapa:14 ppm initiated at age: 9 mo Sex: both Cohort: C2011
This compound had a significant effect on survival:   both sexes p < 0.0001

Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
MetRapa effect on survival, females, test site = All
Log-rank test chisq = 82.5421 p < 0.0001
Wang-Allison test odds ratio = 13.6982 p < 0.0001
Quantiles MetRapa Control % difference
25% died before day: 918 771 +19 %
Median lifespan (days) 1079 873 +24 %
75% died before day: 1197 985 +22 %
90% died before day: 1272 1089 +17 %
Max lifespan observed (days) 1413 1456
Number of mice at start 142 281
Animal censor events are denoted by + marks in the plot
All test sites combined – male
MetRapa effect on survival, males, test site = All
Log-rank test chisq = 43.7855 p < 0.0001
Wang-Allison test odds ratio = 4.3621 p < 0.0001
Quantiles MetRapa Control % difference
25% died before day: 726 595 +22 %
Median lifespan (days) 949 783 +21 %
75% died before day: 1111 921 +21 %
90% died before day: 1205 1057 +14 %
Max lifespan observed (days) 1353 1258
Number of mice at start 158 294
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
MetRapa effect on survival, females, test site = TJL
Log-rank test chisq = 26.5546 p < 0.0001
Wang-Allison test odds ratio = 16.8954 p < 0.0001
Quantiles MetRapa Control % difference
25% died before day: 882 788 +12 %
Median lifespan (days) 1086 892 +22 %
75% died before day: 1213 1015 +20 %
90% died before day: 1295 1106 +17 %
Max lifespan observed (days) 1355 1267
Number of mice at start 48 95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
MetRapa effect on survival, males, test site = TJL
Log-rank test chisq = 25.1337 p < 0.0001
Wang-Allison test odds ratio = 10.1882 p < 0.0001
Quantiles MetRapa Control % difference
25% died before day: 804 587 +37 %
Median lifespan (days) 1030 763 +35 %
75% died before day: 1169 886 +32 %
90% died before day: 1219 1057 +15 %
Max lifespan observed (days) 1282 1258
Number of mice at start 54 101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
MetRapa effect on survival, females, test site = UM
Log-rank test chisq = 32.4147 p < 0.0001
Wang-Allison test odds ratio = 35.6857 p < 0.0001
Quantiles MetRapa Control % difference
25% died before day: 980 750 +31 %
Median lifespan (days) 1094 872 +25 %
75% died before day: 1199 979 +22 %
90% died before day: 1242 1081 +15 %
Max lifespan observed (days) 1413 1456
Number of mice at start 50 95
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
MetRapa effect on survival, males, test site = UM
Log-rank test chisq = 11.9326 p = 0.0006
Wang-Allison test odds ratio = 3.6478 p = 0.0363
Quantiles MetRapa Control % difference
25% died before day: 774 712 +9 %
Median lifespan (days) 1021 860 +19 %
75% died before day: 1141 983 +16 %
90% died before day: 1208 1121 +8 %
Max lifespan observed (days) 1353 1251
Number of mice at start 53 94
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
MetRapa effect on survival, females, test site = UT
Log-rank test chisq = 23.8506 p < 0.0001
Wang-Allison test odds ratio = 6.2966 p = 0.002
Quantiles MetRapa Control % difference
25% died before day: 897 754 +19 %
Median lifespan (days) 1054 857 +23 %
75% died before day: 1164 977 +19 %
90% died before day: 1287 1089 +18 %
Max lifespan observed (days) 1384 1301
Number of mice at start 44 91
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
MetRapa effect on survival, males, test site = UT
Log-rank test chisq = 8.9929 p = 0.0027
Wang-Allison test odds ratio = 2.4293 p = 0.1481
Quantiles MetRapa Control % difference
25% died before day: 622 542 +15 %
Median lifespan (days) 827 715 +16 %
75% died before day: 982 857 +15 %
90% died before day: 1098 1013 +8 %
Max lifespan observed (days) 1241 1186
Number of mice at start 51 99
Animal censor events are denoted by + marks in the plot


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Statistical definitions