ITP survival analysis: metformin and rapamycin
Intervention:
metformin and rapamycin
Trial code: MetRapa
Dose: Met:1000 ppm and Rapa:14 ppm
initiated at age: 9 mo
Sex: both
Cohort: C2011
This compound had a significant effect on survival: both sexes p < 0.0001
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
MetRapa effect on survival,
females, test site = All
Log-rank test
chisq = 82.5421
p < 0.0001
Wang-Allison test
odds ratio = 13.6982
p < 0.0001
Quantiles
MetRapa
Control
% difference
25% died before day:
918
771
+19 %
Median lifespan (days)
1079
873
+24 %
75% died before day:
1197
985
+22 %
90% died before day:
1272
1089
+17 %
Max lifespan observed (days)
1413
1456
Number of mice at start
142
281
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
MetRapa effect on survival,
males, test site = All
Log-rank test
chisq = 43.7855
p < 0.0001
Wang-Allison test
odds ratio = 4.3621
p < 0.0001
Quantiles
MetRapa
Control
% difference
25% died before day:
726
595
+22 %
Median lifespan (days)
949
783
+21 %
75% died before day:
1111
921
+21 %
90% died before day:
1205
1057
+14 %
Max lifespan observed (days)
1353
1258
Number of mice at start
158
294
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
MetRapa effect on survival,
females, test site = TJL
Log-rank test
chisq = 26.5546
p < 0.0001
Wang-Allison test
odds ratio = 16.8954
p < 0.0001
Quantiles
MetRapa
Control
% difference
25% died before day:
882
788
+12 %
Median lifespan (days)
1086
892
+22 %
75% died before day:
1213
1015
+20 %
90% died before day:
1295
1106
+17 %
Max lifespan observed (days)
1355
1267
Number of mice at start
48
95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
MetRapa effect on survival,
males, test site = TJL
Log-rank test
chisq = 25.1337
p < 0.0001
Wang-Allison test
odds ratio = 10.1882
p < 0.0001
Quantiles
MetRapa
Control
% difference
25% died before day:
804
587
+37 %
Median lifespan (days)
1030
763
+35 %
75% died before day:
1169
886
+32 %
90% died before day:
1219
1057
+15 %
Max lifespan observed (days)
1282
1258
Number of mice at start
54
101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
MetRapa effect on survival,
females, test site = UM
Log-rank test
chisq = 32.4147
p < 0.0001
Wang-Allison test
odds ratio = 35.6857
p < 0.0001
Quantiles
MetRapa
Control
% difference
25% died before day:
980
750
+31 %
Median lifespan (days)
1094
872
+25 %
75% died before day:
1199
979
+22 %
90% died before day:
1242
1081
+15 %
Max lifespan observed (days)
1413
1456
Number of mice at start
50
95
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
MetRapa effect on survival,
males, test site = UM
Log-rank test
chisq = 11.9326
p = 0.0006
Wang-Allison test
odds ratio = 3.6478
p = 0.0363
Quantiles
MetRapa
Control
% difference
25% died before day:
774
712
+9 %
Median lifespan (days)
1021
860
+19 %
75% died before day:
1141
983
+16 %
90% died before day:
1208
1121
+8 %
Max lifespan observed (days)
1353
1251
Number of mice at start
53
94
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
MetRapa effect on survival,
females, test site = UT
Log-rank test
chisq = 23.8506
p < 0.0001
Wang-Allison test
odds ratio = 6.2966
p = 0.002
Quantiles
MetRapa
Control
% difference
25% died before day:
897
754
+19 %
Median lifespan (days)
1054
857
+23 %
75% died before day:
1164
977
+19 %
90% died before day:
1287
1089
+18 %
Max lifespan observed (days)
1384
1301
Number of mice at start
44
91
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
MetRapa effect on survival,
males, test site = UT
Log-rank test
chisq = 8.9929
p = 0.0027
Wang-Allison test
odds ratio = 2.4293
p = 0.1481
Quantiles
MetRapa
Control
% difference
25% died before day:
622
542
+15 %
Median lifespan (days)
827
715
+16 %
75% died before day:
982
857
+15 %
90% died before day:
1098
1013
+8 %
Max lifespan observed (days)
1241
1186
Number of mice at start
51
99
Animal censor events are denoted by + marks in the plot
See our
ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions