ITP survival analysis: metformin
Intervention:
metformin
anti-diabetic, anti aging
Trial code: Met
Dose: 1000 ppm
initiated at age: 9 mo
Sex: both
Cohort: C2011
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
Met effect on survival,
females, test site = All
Log-rank test
chisq = 0.1241
p = 0.7246
Wang-Allison test
odds ratio = 0.8259
p = 0.617
Quantiles
Met
Control
% difference
25% died before day:
776
771
+1 %
Median lifespan (days)
872
873
0 %
75% died before day:
986
985
0 %
90% died before day:
1080
1089
-1 %
Max lifespan observed (days)
1259
1456
Number of mice at start
140
281
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
Met effect on survival,
males, test site = All
Log-rank test
chisq = 0.8817
p = 0.3477
Wang-Allison test
odds ratio = 0.6957
p = 0.3236
Quantiles
Met
Control
% difference
25% died before day:
650
595
+9 %
Median lifespan (days)
844
783
+8 %
75% died before day:
955
921
+4 %
90% died before day:
1044
1057
-1 %
Max lifespan observed (days)
1233
1258
Number of mice at start
148
294
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
Met effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.2318
p = 0.6302
Wang-Allison test
odds ratio = 0.9885
p = 1.0
Quantiles
Met
Control
% difference
25% died before day:
762
788
-3 %
Median lifespan (days)
867
892
-3 %
75% died before day:
1002
1015
-1 %
90% died before day:
1113
1106
+1 %
Max lifespan observed (days)
1259
1267
Number of mice at start
48
95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
Met effect on survival,
males, test site = TJL
Log-rank test
chisq = 2.321
p = 0.1276
Wang-Allison test
odds ratio = 1.1605
p = 0.7863
Quantiles
Met
Control
% difference
25% died before day:
680
587
+16 %
Median lifespan (days)
859
763
+13 %
75% died before day:
980
886
+11 %
90% died before day:
1093
1057
+3 %
Max lifespan observed (days)
1209
1258
Number of mice at start
53
101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
Met effect on survival,
females, test site = UM
Log-rank test
chisq = 0.1981
p = 0.6563
Wang-Allison test
odds ratio = 1.3305
p = 0.5803
Quantiles
Met
Control
% difference
25% died before day:
796
750
+6 %
Median lifespan (days)
864
872
-1 %
75% died before day:
1005
979
+3 %
90% died before day:
1142
1081
+6 %
Max lifespan observed (days)
1254
1456
Number of mice at start
49
95
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
Met effect on survival,
males, test site = UM
Log-rank test
chisq = 0.1627
p = 0.6866
Wang-Allison test
odds ratio = 0.3021
p = 0.1406
Quantiles
Met
Control
% difference
25% died before day:
708
712
-1 %
Median lifespan (days)
855
860
-1 %
75% died before day:
1019
983
+4 %
90% died before day:
1061
1121
-5 %
Max lifespan observed (days)
1233
1251
Number of mice at start
47
94
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
Met effect on survival,
females, test site = UT
Log-rank test
chisq = 0.3894
p = 0.5326
Wang-Allison test
odds ratio = 0.3234
p = 0.2246
Quantiles
Met
Control
% difference
25% died before day:
779
754
+3 %
Median lifespan (days)
884
857
+3 %
75% died before day:
977
977
0 %
90% died before day:
1026
1089
-6 %
Max lifespan observed (days)
1078
1301
Number of mice at start
43
91
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
Met effect on survival,
males, test site = UT
Log-rank test
chisq = 0.1689
p = 0.6811
Wang-Allison test
odds ratio = 0.7288
p = 0.7742
Quantiles
Met
Control
% difference
25% died before day:
586
542
+8 %
Median lifespan (days)
790
715
+10 %
75% died before day:
902
857
+5 %
90% died before day:
985
1013
-3 %
Max lifespan observed (days)
1099
1186
Number of mice at start
48
99
Animal censor events are denoted by + marks in the plot
See our
ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions