ITP survival analysis: glycine
This compound had a significant effect on survival: females p = 0.0167; males p = 0.0024
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
Gly effect on survival,
females, test site = All
Log-rank test
chisq = 5.7312
p = 0.0167
Wang-Allison test
odds ratio = 1.5443
p = 0.2188
Quantiles
Gly
Control
% difference
25% died before day:
800
764
+5 %
Median lifespan (days)
930
897
+4 %
75% died before day:
1060
1018
+4 %
90% died before day:
1129
1109
+2 %
Max lifespan observed (days)
1364
1358
Number of mice at start
132
279
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
Gly effect on survival,
males, test site = All
Log-rank test
chisq = 9.2348
p = 0.0024
Wang-Allison test
odds ratio = 2.6047
p = 0.0043
Quantiles
Gly
Control
% difference
25% died before day:
681
638
+7 %
Median lifespan (days)
884
832
+6 %
75% died before day:
1016
969
+5 %
90% died before day:
1108
1059
+5 %
Max lifespan observed (days)
1238
1272
Number of mice at start
153
273
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
Gly effect on survival,
females, test site = TJL
Log-rank test
chisq = 6.3709
p = 0.0116
Wang-Allison test
odds ratio = 3.4281
p = 0.0389
Quantiles
Gly
Control
% difference
25% died before day:
882
782
+13 %
Median lifespan (days)
959
904
+6 %
75% died before day:
1072
1010
+6 %
90% died before day:
1190
1099
+8 %
Max lifespan observed (days)
1364
1358
Number of mice at start
48
96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
Gly effect on survival,
males, test site = TJL
Log-rank test
chisq = 1.016
p = 0.3135
Wang-Allison test
odds ratio = 2.125
p = 0.17
Quantiles
Gly
Control
% difference
25% died before day:
658
572
+15 %
Median lifespan (days)
886
873
+1 %
75% died before day:
1029
992
+4 %
90% died before day:
1123
1068
+5 %
Max lifespan observed (days)
1203
1272
Number of mice at start
54
93
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
Gly effect on survival,
females, test site = UM
Log-rank test
chisq = 1.5877
p = 0.2077
Wang-Allison test
odds ratio = 0.9123
p = 1.0
Quantiles
Gly
Control
% difference
25% died before day:
763
748
+2 %
Median lifespan (days)
925
884
+5 %
75% died before day:
1089
1016
+7 %
90% died before day:
1129
1139
-1 %
Max lifespan observed (days)
1250
1210
Number of mice at start
43
91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
Gly effect on survival,
males, test site = UM
Log-rank test
chisq = 2.1927
p = 0.1387
Wang-Allison test
odds ratio = 2.5799
p = 0.1391
Quantiles
Gly
Control
% difference
25% died before day:
722
756
-4 %
Median lifespan (days)
900
894
+1 %
75% died before day:
1082
1009
+7 %
90% died before day:
1138
1084
+5 %
Max lifespan observed (days)
1221
1206
Number of mice at start
48
84
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
Gly effect on survival,
females, test site = UT
Log-rank test
chisq = 0.068
p = 0.7943
Wang-Allison test
odds ratio = 0.9732
p = 1.0
Quantiles
Gly
Control
% difference
25% died before day:
768
768
0 %
Median lifespan (days)
872
882
-1 %
75% died before day:
1005
1046
-4 %
90% died before day:
1106
1109
0 %
Max lifespan observed (days)
1254
1238
Number of mice at start
41
92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
Gly effect on survival,
males, test site = UT
Log-rank test
chisq = 7.637
p = 0.0057
Wang-Allison test
odds ratio = 3.186
p = 0.0435
Quantiles
Gly
Control
% difference
25% died before day:
654
570
+15 %
Median lifespan (days)
810
743
+9 %
75% died before day:
985
892
+10 %
90% died before day:
1073
977
+10 %
Max lifespan observed (days)
1238
1167
Number of mice at start
51
96
Animal censor events are denoted by + marks in the plot
See our
ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions