ITP survival analysis:   glycine

Intervention:   glycine     amino acid dietary supplement, anti-aging
Trial code: Gly Dose: 80,000 ppm initiated at age: 9 mo Sex: both Cohort: C2014
This compound had a significant effect on survival:   females p = 0.0167; males p = 0.0024

Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
Gly effect on survival, females, test site = All
Log-rank test chisq = 5.7312 p = 0.0167
Wang-Allison test odds ratio = 1.5443 p = 0.2188
Quantiles Gly Control % difference
25% died before day: 800 764 +5 %
Median lifespan (days) 930 897 +4 %
75% died before day: 1060 1018 +4 %
90% died before day: 1129 1109 +2 %
Max lifespan observed (days) 1364 1358
Number of mice at start 132 279
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Gly effect on survival, males, test site = All
Log-rank test chisq = 9.2348 p = 0.0024
Wang-Allison test odds ratio = 2.6047 p = 0.0043
Quantiles Gly Control % difference
25% died before day: 681 638 +7 %
Median lifespan (days) 884 832 +6 %
75% died before day: 1016 969 +5 %
90% died before day: 1108 1059 +5 %
Max lifespan observed (days) 1238 1272
Number of mice at start 153 273
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
Gly effect on survival, females, test site = TJL
Log-rank test chisq = 6.3709 p = 0.0116
Wang-Allison test odds ratio = 3.4281 p = 0.0389
Quantiles Gly Control % difference
25% died before day: 882 782 +13 %
Median lifespan (days) 959 904 +6 %
75% died before day: 1072 1010 +6 %
90% died before day: 1190 1099 +8 %
Max lifespan observed (days) 1364 1358
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
Gly effect on survival, males, test site = TJL
Log-rank test chisq = 1.016 p = 0.3135
Wang-Allison test odds ratio = 2.125 p = 0.17
Quantiles Gly Control % difference
25% died before day: 658 572 +15 %
Median lifespan (days) 886 873 +1 %
75% died before day: 1029 992 +4 %
90% died before day: 1123 1068 +5 %
Max lifespan observed (days) 1203 1272
Number of mice at start 54 93
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
Gly effect on survival, females, test site = UM
Log-rank test chisq = 1.5877 p = 0.2077
Wang-Allison test odds ratio = 0.9123 p = 1.0
Quantiles Gly Control % difference
25% died before day: 763 748 +2 %
Median lifespan (days) 925 884 +5 %
75% died before day: 1089 1016 +7 %
90% died before day: 1129 1139 -1 %
Max lifespan observed (days) 1250 1210
Number of mice at start 43 91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
Gly effect on survival, males, test site = UM
Log-rank test chisq = 2.1927 p = 0.1387
Wang-Allison test odds ratio = 2.5799 p = 0.1391
Quantiles Gly Control % difference
25% died before day: 722 756 -4 %
Median lifespan (days) 900 894 +1 %
75% died before day: 1082 1009 +7 %
90% died before day: 1138 1084 +5 %
Max lifespan observed (days) 1221 1206
Number of mice at start 48 84
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
Gly effect on survival, females, test site = UT
Log-rank test chisq = 0.068 p = 0.7943
Wang-Allison test odds ratio = 0.9732 p = 1.0
Quantiles Gly Control % difference
25% died before day: 768 768 0 %
Median lifespan (days) 872 882 -1 %
75% died before day: 1005 1046 -4 %
90% died before day: 1106 1109 0 %
Max lifespan observed (days) 1254 1238
Number of mice at start 41 92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
Gly effect on survival, males, test site = UT
Log-rank test chisq = 7.637 p = 0.0057
Wang-Allison test odds ratio = 3.186 p = 0.0435
Quantiles Gly Control % difference
25% died before day: 654 570 +15 %
Median lifespan (days) 810 743 +9 %
75% died before day: 985 892 +10 %
90% died before day: 1073 977 +10 %
Max lifespan observed (days) 1238 1167
Number of mice at start 51 96
Animal censor events are denoted by + marks in the plot


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Statistical definitions