ITP survival analysis:   green tea extract

Intervention:   green tea extract     dietary supplement, anti-oxidant
Trial code: GTE Dose: 2000 ppm initiated at age: 4 mo Sex: both Cohort: C2007
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
GTE effect on survival, females, test site = All
Log-rank test chisq = 0.8084 p = 0.3686
Wang-Allison test odds ratio = 0.8379 p = 0.7276
Quantiles GTE Control % difference
25% died before day: 821 753 +9 %
Median lifespan (days) 923 865 +7 %
75% died before day: 999 994 +1 %
90% died before day: 1075 1088 -1 %
Max lifespan observed (days) 1262 1359
Number of mice at start 129 275
Animal censor events are denoted by + marks in the plot
All test sites combined – male
GTE effect on survival, males, test site = All
Log-rank test chisq = 0.7324 p = 0.3921
Wang-Allison test odds ratio = 1.4274 p = 0.3099
Quantiles GTE Control % difference
25% died before day: 628 588 +7 %
Median lifespan (days) 822 784 +5 %
75% died before day: 969 954 +2 %
90% died before day: 1084 1074 +1 %
Max lifespan observed (days) 1325 1247
Number of mice at start 145 276
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
GTE effect on survival, females, test site = TJL
Log-rank test chisq = 0.0045 p = 0.9464
Wang-Allison test odds ratio = 0.3274 p = 0.2245
Quantiles GTE Control % difference
25% died before day: 804 740 +9 %
Median lifespan (days) 937 860 +9 %
75% died before day: 1012 1016 0 %
90% died before day: 1083 1111 -3 %
Max lifespan observed (days) 1108 1340
Number of mice at start 43 92
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
GTE effect on survival, males, test site = TJL
Log-rank test chisq = 0.2641 p = 0.6073
Wang-Allison test odds ratio = 0.8358 p = 1.0
Quantiles GTE Control % difference
25% died before day: 622 569 +9 %
Median lifespan (days) 768 728 +5 %
75% died before day: 934 923 +1 %
90% died before day: 1028 1039 -1 %
Max lifespan observed (days) 1159 1200
Number of mice at start 46 87
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
GTE effect on survival, females, test site = UM
Log-rank test chisq = 0.0013 p = 0.9708
Wang-Allison test odds ratio = 0.5617 p = 0.5471
Quantiles GTE Control % difference
25% died before day: 835 767 +9 %
Median lifespan (days) 934 900 +4 %
75% died before day: 990 999 -1 %
90% died before day: 1053 1114 -5 %
Max lifespan observed (days) 1187 1359
Number of mice at start 42 91
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
GTE effect on survival, males, test site = UM
Log-rank test chisq = 3.7499 p = 0.0528
Wang-Allison test odds ratio = 3.0806 p = 0.0466
Quantiles GTE Control % difference
25% died before day: 747 659 +13 %
Median lifespan (days) 887 793 +12 %
75% died before day: 1024 953 +7 %
90% died before day: 1129 1076 +5 %
Max lifespan observed (days) 1325 1191
Number of mice at start 51 93
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
GTE effect on survival, females, test site = UT
Log-rank test chisq = 2.3387 p = 0.1262
Wang-Allison test odds ratio = 2.2819 p = 0.1449
Quantiles GTE Control % difference
25% died before day: 826 756 +9 %
Median lifespan (days) 908 840 +8 %
75% died before day: 970 962 +1 %
90% died before day: 1075 1045 +3 %
Max lifespan observed (days) 1262 1261
Number of mice at start 44 92
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
GTE effect on survival, males, test site = UT
Log-rank test chisq = 1.1632 p = 0.2808
Wang-Allison test odds ratio = 1.0 p = 1.0
Quantiles GTE Control % difference
25% died before day: 568 584 -3 %
Median lifespan (days) 784 810 -3 %
75% died before day: 938 1010 -7 %
90% died before day: 1081 1132 -5 %
Max lifespan observed (days) 1192 1247
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot


See our ITP data portal page for more information on National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.

Statistical definitions