ITP survival analysis: enalapril
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
Enal effect on survival,
females, test site = All
Log-rank test
chisq = 0.0157
p = 0.9001
Wang-Allison test
odds ratio = 0.7329
p = 0.4868
Quantiles
Enal
Control
% difference
25% died before day:
741
756
-2 %
Median lifespan (days)
868
886
-2 %
75% died before day:
1009
983
+3 %
90% died before day:
1098
1094
0 %
Max lifespan observed (days)
1232
1281
Number of mice at start
139
289
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
Enal effect on survival,
males, test site = All
Log-rank test
chisq = 1.5044
p = 0.22
Wang-Allison test
odds ratio = 0.9942
p = 1.0
Quantiles
Enal
Control
% difference
25% died before day:
708
597
+19 %
Median lifespan (days)
846
794
+7 %
75% died before day:
955
964
-1 %
90% died before day:
1091
1078
+1 %
Max lifespan observed (days)
1227
1303
Number of mice at start
170
357
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
Enal effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.438
p = 0.5081
Wang-Allison test
odds ratio = 0.8726
p = 1.0
Quantiles
Enal
Control
% difference
25% died before day:
696
748
-7 %
Median lifespan (days)
878
881
0 %
75% died before day:
1004
952
+5 %
90% died before day:
1070
1100
-3 %
Max lifespan observed (days)
1232
1229
Number of mice at start
43
95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
Enal effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.7574
p = 0.3841
Wang-Allison test
odds ratio = 0.5601
p = 0.4349
Quantiles
Enal
Control
% difference
25% died before day:
646
575
+12 %
Median lifespan (days)
797
802
-1 %
75% died before day:
885
937
-6 %
90% died before day:
994
1035
-4 %
Max lifespan observed (days)
1184
1220
Number of mice at start
57
126
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
Enal effect on survival,
females, test site = UM
Log-rank test
chisq = 0.9938
p = 0.3188
Wang-Allison test
odds ratio = 1.0058
p = 1.0
Quantiles
Enal
Control
% difference
25% died before day:
800
731
+9 %
Median lifespan (days)
948
878
+8 %
75% died before day:
1076
1016
+6 %
90% died before day:
1108
1094
+1 %
Max lifespan observed (days)
1215
1248
Number of mice at start
44
95
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
Enal effect on survival,
males, test site = UM
Log-rank test
chisq = 0.1638
p = 0.6857
Wang-Allison test
odds ratio = 0.9473
p = 1.0
Quantiles
Enal
Control
% difference
25% died before day:
801
676
+18 %
Median lifespan (days)
924
895
+3 %
75% died before day:
1059
1042
+2 %
90% died before day:
1141
1141
0 %
Max lifespan observed (days)
1227
1303
Number of mice at start
54
112
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
Enal effect on survival,
females, test site = UT
Log-rank test
chisq = 2.0586
p = 0.1513
Wang-Allison test
odds ratio = 0.4552
p = 0.2666
Quantiles
Enal
Control
% difference
25% died before day:
704
776
-9 %
Median lifespan (days)
837
896
-7 %
75% died before day:
958
984
-3 %
90% died before day:
1046
1089
-4 %
Max lifespan observed (days)
1224
1281
Number of mice at start
52
99
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
Enal effect on survival,
males, test site = UT
Log-rank test
chisq = 6.0464
p = 0.0139
Wang-Allison test
odds ratio = 1.7044
p = 0.2993
Quantiles
Enal
Control
% difference
25% died before day:
673
527
+28 %
Median lifespan (days)
849
722
+18 %
75% died before day:
952
865
+10 %
90% died before day:
1055
1020
+3 %
Max lifespan observed (days)
1226
1176
Number of mice at start
59
119
Animal censor events are denoted by + marks in the plot
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ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions