ITP survival analysis: caffeic acid phenethyl ester
Intervention:
caffeic acid phenethyl ester
anti-oxidant
Trial code: CAPE_lo
Dose: 30 ppm
initiated at age: 4 mo
Sex: both
Cohort: C2005
Trial code: CAPE_hi
Dose: 300 ppm
initiated at age: 4 mo
Sex: both
Cohort: C2005
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
CAPE_lo effect on survival,
females, test site = All
Log-rank test
chisq = 0.0392
p = 0.8431
Wang-Allison test
odds ratio = 0.7534
p = 0.499
Quantiles
CAPE_lo
Control
% difference
25% died before day:
768
756
+2 %
Median lifespan (days)
884
886
0 %
75% died before day:
982
983
0 %
90% died before day:
1088
1094
-1 %
Max lifespan observed (days)
1257
1281
Number of mice at start
140
289
Animal censor events are denoted by + marks in the plot
CAPE_hi effect on survival,
females, test site = All
Log-rank test
chisq = 3.3667
p = 0.0665
Wang-Allison test
odds ratio = 1.0795
p = 0.8651
Quantiles
CAPE_hi
Control
% difference
25% died before day:
788
756
+4 %
Median lifespan (days)
926
886
+5 %
75% died before day:
1027
983
+4 %
90% died before day:
1104
1094
+1 %
Max lifespan observed (days)
1399
1281
Number of mice at start
147
289
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
CAPE_lo effect on survival,
males, test site = All
Log-rank test
chisq = 0.0197
p = 0.8883
Wang-Allison test
odds ratio = 0.6171
p = 0.1698
Quantiles
CAPE_lo
Control
% difference
25% died before day:
648
597
+9 %
Median lifespan (days)
817
794
+3 %
75% died before day:
965
964
0 %
90% died before day:
1044
1078
-3 %
Max lifespan observed (days)
1283
1303
Number of mice at start
175
357
Animal censor events are denoted by + marks in the plot
CAPE_hi effect on survival,
males, test site = All
Log-rank test
chisq = 0.062
p = 0.8033
Wang-Allison test
odds ratio = 0.8102
p = 0.5405
Quantiles
CAPE_hi
Control
% difference
25% died before day:
624
597
+5 %
Median lifespan (days)
810
794
+2 %
75% died before day:
959
964
-1 %
90% died before day:
1063
1078
-1 %
Max lifespan observed (days)
1297
1303
Number of mice at start
171
357
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
CAPE_lo effect on survival,
females, test site = TJL
Log-rank test
chisq = 1.3333
p = 0.2482
Wang-Allison test
odds ratio = 1.2232
p = 0.7659
Quantiles
CAPE_lo
Control
% difference
25% died before day:
823
748
+10 %
Median lifespan (days)
915
881
+4 %
75% died before day:
976
952
+3 %
90% died before day:
1115
1100
+1 %
Max lifespan observed (days)
1231
1229
Number of mice at start
44
95
Animal censor events are denoted by + marks in the plot
CAPE_hi effect on survival,
females, test site = TJL
Log-rank test
chisq = 6.8741
p = 0.0087
Wang-Allison test
odds ratio = 1.5679
p = 0.5511
Quantiles
CAPE_hi
Control
% difference
25% died before day:
850
748
+14 %
Median lifespan (days)
962
881
+9 %
75% died before day:
1043
952
+10 %
90% died before day:
1141
1100
+4 %
Max lifespan observed (days)
1263
1229
Number of mice at start
48
95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
CAPE_lo effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.0583
p = 0.8092
Wang-Allison test
odds ratio = 0.5708
p = 0.4354
Quantiles
CAPE_lo
Control
% difference
25% died before day:
642
575
+12 %
Median lifespan (days)
790
802
-1 %
75% died before day:
920
937
-2 %
90% died before day:
1010
1035
-2 %
Max lifespan observed (days)
1243
1220
Number of mice at start
56
126
Animal censor events are denoted by + marks in the plot
CAPE_hi effect on survival,
males, test site = TJL
Log-rank test
chisq = 0.7513
p = 0.3861
Wang-Allison test
odds ratio = 1.3209
p = 0.5869
Quantiles
CAPE_hi
Control
% difference
25% died before day:
637
575
+11 %
Median lifespan (days)
838
802
+4 %
75% died before day:
970
937
+4 %
90% died before day:
1065
1035
+3 %
Max lifespan observed (days)
1297
1220
Number of mice at start
54
126
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
CAPE_lo effect on survival,
females, test site = UM
Log-rank test
chisq = 0.1373
p = 0.711
Wang-Allison test
odds ratio = 0.6959
p = 0.7736
Quantiles
CAPE_lo
Control
% difference
25% died before day:
790
731
+8 %
Median lifespan (days)
896
878
+2 %
75% died before day:
998
1016
-2 %
90% died before day:
1087
1094
-1 %
Max lifespan observed (days)
1257
1248
Number of mice at start
48
95
Animal censor events are denoted by + marks in the plot
CAPE_hi effect on survival,
females, test site = UM
Log-rank test
chisq = 1.2335
p = 0.2667
Wang-Allison test
odds ratio = 1.164
p = 0.7718
Quantiles
CAPE_hi
Control
% difference
25% died before day:
788
731
+8 %
Median lifespan (days)
930
878
+6 %
75% died before day:
1047
1016
+3 %
90% died before day:
1133
1094
+4 %
Max lifespan observed (days)
1399
1248
Number of mice at start
48
95
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
CAPE_lo effect on survival,
males, test site = UM
Log-rank test
chisq = 1.6621
p = 0.1973
Wang-Allison test
odds ratio = 0.373
p = 0.1787
Quantiles
CAPE_lo
Control
% difference
25% died before day:
632
676
-7 %
Median lifespan (days)
881
895
-2 %
75% died before day:
987
1042
-5 %
90% died before day:
1086
1141
-5 %
Max lifespan observed (days)
1283
1303
Number of mice at start
59
112
Animal censor events are denoted by + marks in the plot
CAPE_hi effect on survival,
males, test site = UM
Log-rank test
chisq = 2.1928
p = 0.1387
Wang-Allison test
odds ratio = 0.4137
p = 0.2734
Quantiles
CAPE_hi
Control
% difference
25% died before day:
680
676
+1 %
Median lifespan (days)
846
895
-5 %
75% died before day:
1027
1042
-1 %
90% died before day:
1087
1141
-5 %
Max lifespan observed (days)
1193
1303
Number of mice at start
54
112
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
CAPE_lo effect on survival,
females, test site = UT
Log-rank test
chisq = 1.5096
p = 0.2192
Wang-Allison test
odds ratio = 0.4855
p = 0.3867
Quantiles
CAPE_lo
Control
% difference
25% died before day:
714
776
-8 %
Median lifespan (days)
852
896
-5 %
75% died before day:
936
984
-5 %
90% died before day:
1039
1089
-5 %
Max lifespan observed (days)
1204
1281
Number of mice at start
48
99
Animal censor events are denoted by + marks in the plot
CAPE_hi effect on survival,
females, test site = UT
Log-rank test
chisq = 0.3605
p = 0.5482
Wang-Allison test
odds ratio = 0.6825
p = 0.7746
Quantiles
CAPE_hi
Control
% difference
25% died before day:
749
776
-3 %
Median lifespan (days)
858
896
-4 %
75% died before day:
1001
984
+2 %
90% died before day:
1070
1089
-2 %
Max lifespan observed (days)
1206
1281
Number of mice at start
51
99
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
CAPE_lo effect on survival,
males, test site = UT
Log-rank test
chisq = 2.6921
p = 0.1008
Wang-Allison test
odds ratio = 0.9908
p = 1.0
Quantiles
CAPE_lo
Control
% difference
25% died before day:
662
527
+26 %
Median lifespan (days)
766
722
+6 %
75% died before day:
946
865
+9 %
90% died before day:
1029
1020
+1 %
Max lifespan observed (days)
1221
1176
Number of mice at start
60
119
Animal censor events are denoted by + marks in the plot
CAPE_hi effect on survival,
males, test site = UT
Log-rank test
chisq = 0.0031
p = 0.9554
Wang-Allison test
odds ratio = 0.859
p = 1.0
Quantiles
CAPE_hi
Control
% difference
25% died before day:
603
527
+14 %
Median lifespan (days)
710
722
-2 %
75% died before day:
871
865
+1 %
90% died before day:
1010
1020
-1 %
Max lifespan observed (days)
1147
1176
Number of mice at start
63
119
Animal censor events are denoted by + marks in the plot
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Statistical definitions