ITP survival analysis: 17-a-estradiol
This compound had a significant effect on survival: males p < 0.0001
Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.
All test sites combined – female
Survival analysis details -- Female
17aE2_hi effect on survival,
females, test site = All
Log-rank test
chisq = 0.0009
p = 0.9763
Wang-Allison test
odds ratio = 0.8918
p = 0.8638
Quantiles
17aE2_hi
Control
% difference
25% died before day:
773
771
0 %
Median lifespan (days)
893
873
+2 %
75% died before day:
1007
985
+2 %
90% died before day:
1091
1089
0 %
Max lifespan observed (days)
1252
1456
Number of mice at start
135
281
Animal censor events are denoted by + marks in the plot
All test sites combined – male
Survival analysis details -- Male
17aE2_hi effect on survival,
males, test site = All
Log-rank test
chisq = 36.5057
p < 0.0001
Wang-Allison test
odds ratio = 4.3647
p < 0.0001
Quantiles
17aE2_hi
Control
% difference
25% died before day:
755
595
+27 %
Median lifespan (days)
918
783
+17 %
75% died before day:
1086
921
+18 %
90% died before day:
1211
1057
+15 %
Max lifespan observed (days)
1375
1258
Number of mice at start
144
294
Animal censor events are denoted by + marks in the plot
By individual test site:
TJL – female
TJL – female
Survival analysis details
17aE2_hi effect on survival,
females, test site = TJL
Log-rank test
chisq = 0.7434
p = 0.3886
Wang-Allison test
odds ratio = 0.4633
p = 0.3862
Quantiles
17aE2_hi
Control
% difference
25% died before day:
829
788
+5 %
Median lifespan (days)
872
892
-2 %
75% died before day:
986
1015
-3 %
90% died before day:
1065
1106
-4 %
Max lifespan observed (days)
1159
1267
Number of mice at start
48
95
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male
Survival analysis details
17aE2_hi effect on survival,
males, test site = TJL
Log-rank test
chisq = 20.4343
p < 0.0001
Wang-Allison test
odds ratio = 10.1882
p < 0.0001
Quantiles
17aE2_hi
Control
% difference
25% died before day:
769
587
+31 %
Median lifespan (days)
960
763
+26 %
75% died before day:
1162
886
+31 %
90% died before day:
1242
1057
+18 %
Max lifespan observed (days)
1322
1258
Number of mice at start
54
101
Animal censor events are denoted by + marks in the plot
UM – female
UM – female
Survival analysis details
17aE2_hi effect on survival,
females, test site = UM
Log-rank test
chisq = 0.1021
p = 0.7494
Wang-Allison test
odds ratio = 1.7556
p = 0.3657
Quantiles
17aE2_hi
Control
% difference
25% died before day:
716
750
-5 %
Median lifespan (days)
835
872
-4 %
75% died before day:
1011
979
+3 %
90% died before day:
1122
1081
+4 %
Max lifespan observed (days)
1252
1456
Number of mice at start
43
95
Animal censor events are denoted by + marks in the plot
UM – male
UM – male
Survival analysis details
17aE2_hi effect on survival,
males, test site = UM
Log-rank test
chisq = 8.5479
p = 0.0035
Wang-Allison test
odds ratio = 3.3191
p = 0.0366
Quantiles
17aE2_hi
Control
% difference
25% died before day:
797
712
+12 %
Median lifespan (days)
940
860
+9 %
75% died before day:
1150
983
+17 %
90% died before day:
1211
1121
+8 %
Max lifespan observed (days)
1363
1251
Number of mice at start
43
94
Animal censor events are denoted by + marks in the plot
UT – female
UT – female
Survival analysis details
17aE2_hi effect on survival,
females, test site = UT
Log-rank test
chisq = 1.2091
p = 0.2715
Wang-Allison test
odds ratio = 0.8113
p = 1.0
Quantiles
17aE2_hi
Control
% difference
25% died before day:
840
754
+11 %
Median lifespan (days)
942
857
+10 %
75% died before day:
1010
977
+3 %
90% died before day:
1087
1089
0 %
Max lifespan observed (days)
1190
1301
Number of mice at start
44
91
Animal censor events are denoted by + marks in the plot
UT – male
UT – male
Survival analysis details
17aE2_hi effect on survival,
males, test site = UT
Log-rank test
chisq = 8.9808
p = 0.0027
Wang-Allison test
odds ratio = 2.6756
p = 0.0816
Quantiles
17aE2_hi
Control
% difference
25% died before day:
689
542
+27 %
Median lifespan (days)
876
715
+23 %
75% died before day:
1002
857
+17 %
90% died before day:
1094
1013
+8 %
Max lifespan observed (days)
1375
1186
Number of mice at start
47
99
Animal censor events are denoted by + marks in the plot
See our
ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.
Statistical definitions