MPD: Measures involving Theiler's murine encephalomyelitis virus

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Brinkmeyer1:1	Brinkmeyer1	body weight	Theiler's murine encephalomyelitis virus	body weight, post infection [g] bw 64401 day 0 day 2 day 4 day 6 day 8 day 10 day 14 day 17 day 22 day 27 (6 more)...	CC	5	both	4wks	N=5	2017

Brinkmeyer1:17	Brinkmeyer1	health assessment	Theiler's murine encephalomyelitis virus	clinical score (0=normal, 6=moribund), post infection [score] clin_score 64417 day 0 day 2 day 4 day 6 day 8 day 12 day 18 day 24 day 29 day 34 (6 more)...	CC	5	both	4wks	N=5	2017

Brinkmeyer1:33	Brinkmeyer1	RNA expression profiling	Theiler's murine encephalomyelitis virus	TMEV transcript abundance (normalized), post infection TMEV 64433 day 7 day 28	CC	4	both	4wks	N=1	2017

Brinkmeyer1:35	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	number of seconds spent grooming, 10 min test, post infection wk 3 (manual assessment) [s] grooming 64435	CC	5	both	4wks	N=2	2017

Brinkmeyer1:36	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	number of times mouse reared, 10 min test, post infection wk 3 (manual assessment) [n] activity_rearing 64436	CC	5	both	4wks	N=2	2017

Brinkmeyer1:37	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	horizontal movement latency, 30 min test, post infection wk 3 [s] horiz_latency 64437 trial 1 trial 2	CC	4	both	4wks	N=2	2017

Brinkmeyer1:39	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	number of horizontal movements (beam breaks), 30 min test, post infection wk 3 [n] horiz_activity 64439 trial 1 trial 2	CC	4	both	4wks	N=2	2017

Brinkmeyer1:41	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	horizontal distance traveled, 30 min test, post infection wk 3 [cm] horiz_distance 64441 trial 1 trial 2	CC	4	both	4wks	N=2	2017

Brinkmeyer1:43	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	time spent moving horizontally, 30 min test, post infection wk 3 [s] horiz_time 64443 trial 1 trial 2	CC	4	both	4wks	N=2	2017

Brinkmeyer1:45	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	horizontal movement velocity, 30 min test, post infection wk 3 [cm/s] horiz_velocity 64445 trial 1 trial 2	CC	4	both	4wks	N=2	2017

Brinkmeyer1:47	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	number of vertical plane entries, 30 min test, post infection wk 3 [n] vert_activity 64447 trial 1 trial 2	CC	4	both	4wks	N=2	2017

Brinkmeyer1:49	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	number of vertical plane episodes, 30 min test, post infection wk 3 [n] vert_episodes 64449 trial 1 trial 2	CC	4	both	4wks	N=2	2017

Brinkmeyer1:51	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	time spent vertical, 30 min test, post infection wk 3 [s] vert_time 64451 trial 1 trial 2	CC	4	both	4wks	N=2	2017

Brinkmeyer1:53	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	time spent resting, 30 min test, post infection wk 3 [s] resting 64453 trial 1 trial 2	CC	4	both	4wks	N=2	2017

Brinkmeyer1:55	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	number of center entries, 30 min test, post infection wk 3 [n] center_entries 64455 trial 1 trial 2	CC	4	both	4wks	N=2	2017

Brinkmeyer1:57	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	time spent in center, 30 min test, post infection wk 3 [s] center_time 64457 trial 1 trial 2	CC	4	both	4wks	N=2	2017

Brinkmeyer1:59	Brinkmeyer1	open field test	Theiler's murine encephalomyelitis virus	time spent in periphery, 30 min test, post infection wk 3 [s] periphery_time 64459 trial 1 trial 2	CC	4	both	4wks	N=2	2017

Brinkmeyer1:61	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	number of steps included in analysis as measured by DigiGait, post infection day 27, forelimb [n] num_steps_fore 64461 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:63	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	number of steps included in analysis as measured by DigiGait, post infection day 27, hindlimb [n] num_steps_hind 64463 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:65	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	duration of swing phase (no paw contact with belt) as measured by DigiGait, post infection day 27, forelimb [s] swing_dur_fore 64465 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:67	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	duration of swing phase (no paw contact with belt) as measured by DigiGait, post infection day 27, hindlimb [s] swing_dur_hind 64467 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:69	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of total stride duration that paw is in air as measured by DigiGait, post infection day 27, forelimb [%] swing_stride_fore 64469 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:71	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of total stride duration that paw is in air as measured by DigiGait, post infection day 27, hindlimb [%] swing_stride_hind 64471 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:73	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	duration of braking phase as measured by DigiGait, post infection day 27, forelimb [s] brake_dur_fore 64473 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:75	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	duration of braking phase as measured by DigiGait, post infection day 27, hindlimb [s] brake_dur_hind 64475 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:77	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of total stride duration that paw is in braking phase as measured by DigiGait, post infection day 27, forelimb [%] brake_stride_fore 64477 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:79	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of total stride duration that paw is in braking phase as measured by DigiGait, post infection day 27, hindlimb [%] brake_stride_hind 64479 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:81	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of stance phase that paw is in braking phase as measured by DigiGait, post infection day 27, forelimb [%] brake_stance_fore 64481 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:83	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of stance phase that paw is in braking phase as measured by DigiGait, post infection day 27, hindlimb [%] brake_stance_hind 64483 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:85	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	duration of propulsion phase as measured by DigiGait, post infection day 27, forelimb [s] propel_dur_fore 64485 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:87	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	duration of propulsion phase as measured by DigiGait, post infection day 27, hindlimb [s] propel_dur_hind 64487 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:89	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of total stride duration that paw is in propulsion phase as measured by DigiGait, post infection day 27, forelimb [%] propel_stride_fore 64489 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:91	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of total stride duration that paw is in propulsion phase as measured by DigiGait, post infection day 27, hindlimb [%] propel_stride_hind 64491 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:93	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of stance phase that paw is in propulsion phase as measured by DigiGait, post infection day 27, forelimb [%] propel_stance_fore 64493 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:95	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of stance phase that paw is in propulsion phase as measured by DigiGait, post infection day 27, hindlimb [%] propel_stance_hind 64495 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:97	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of total stride duration that paw is in any contact with treadmill belt as measured by DigiGait, post infection day 27, forelimb [%] stance_stride_fore 64497 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:99	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	percentage of total stride duration that paw is in any contact with treadmill belt as measured by DigiGait, post infection day 27, hindlimb [%] stance_stride_hind 64499 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:101	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	ratio of swing phase time to stance phase time as measured by DigiGait, post infection day 27, forelimb [ratio] stance_swing_fore 64501 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:103	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	ratio of swing phase time to stance phase time as measured by DigiGait, post infection day 27, hindlimb [ratio] stance_swing_hind 64503 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:105	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	duration of one complete stride for one paw (equal to stance and swing durations) as measured by DigiGait, post infection day 27, forelimb [s] stride_dur_fore 64505 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:107	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	duration of one complete stride for one paw (equal to stance and swing durations) as measured by DigiGait, post infection day 27, hindlimb [s] stride_dur_hind 64507 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:109	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	number of times each second (cadence) that a paw takes a complete stride as measured by DigiGait, post infection day 27, forelimb [n/s] stride_freq_fore 64509 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:111	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	number of times each second (cadence) that a paw takes a complete stride as measured by DigiGait, post infection day 27, hindlimb [n/s] stride_freq_hind 64511 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:113	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	spatial length that a paw traverses through a given stride as measured by DigiGait, post infection day 27, forelimb [cm] stride_length_fore 64513 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:115	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	spatial length that a paw traverses through a given stride as measured by DigiGait, post infection day 27, hindlimb [cm] stride_length_hind 64515 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:117	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	stride length variability as measured by DigiGait, post infection day 27, forelimb [cm] stride_length_var_fore 64517 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:119	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	stride length variability as measured by DigiGait, post infection day 27, hindlimb [cm] stride_length_var_hind 64519 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:121	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	stride length coefficient of variation as measured by DigiGait, post infection day 27, forelimb [%] stride_length_CV_fore 64521 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:123	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	stride length coefficient of variation as measured by DigiGait, post infection day 27, hindlimb [%] stride_length_CV_hind 64523 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:125	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	angle that paw makes with long axis of direction of motion of mouse as measured by DigiGait, post infection day 27, forelimb [deg] paw_angle_fore 64525 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:127	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	angle that paw makes with long axis of direction of motion of mouse as measured by DigiGait, post infection day 27, hindlimb [deg] paw_angle_hind 64527 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:129	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	standard deviation of paw angle for set of strides recorded as measured by DigiGait, post infection day 27, forelimb [deg] paw_angle_SD_fore 64529 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:131	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	standard deviation of paw angle for set of strides recorded as measured by DigiGait, post infection day 27, hindlimb [deg] paw_angle_SD_hind 64531 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:133	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	maximal paw area as measured by DigiGait, post infection day 27, forelimb [cm²] paw_area_max_fore 64533 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:135	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	maximal paw area as measured by DigiGait, post infection day 27, hindlimb [cm²] paw_area_max_hind 64535 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:137	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	standard deviation of paw area for set of strides recorded as measured by DigiGait, post infection day 27, forelimb [cm²] paw_area_SD_fore 64537 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:139	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	standard deviation of paw area for set of strides recorded as measured by DigiGait, post infection day 27, hindlimb [cm²] paw_area_SD_hind 64539 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:141	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	ratio of forelimb stepping to fore limb stepping frequency (coordination metric) as measured by DigiGait, post infection day 27, forelimb [ratio] gait_symmetry_fore 64541 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:143	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	ratio of forelimb stepping to hind limb stepping frequency (coordination metric) as measured by DigiGait, post infection day 27, hindlimb [ratio] gait_symmetry_hind 64543 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:145	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	maximal rate of change in paw area in contact with treadmill belt during braking phase as measured by DigiGait, post infection day 27, forelimb [cm²/s] max_area_break_fore 64545 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:147	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	maximal rate of change in paw area in contact with treadmill belt during braking phase as measured by DigiGait, post infection day 27, hindlimb [cm²/s] max_area_break_hind 64547 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:149	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	maximal rate of change in paw area in contact with treadmill belt during propulsion phase as measured by DigiGait, post infection day 27, forelimb [cm²/s] max_area_propuls_fore 64549 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:151	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	maximal rate of change in paw area in contact with treadmill belt during propulsion phase as measured by DigiGait, post infection day 27, hindlimb [cm²/s] max_area_propuls_hind 64551 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:153	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	overlap extent of ipsilateral fore and hind paws as measured by DigiGait, post infection day 27, forelimb [cm] overlap_distance_fore 64553 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:155	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	overlap extent of ipsilateral fore and hind paws as measured by DigiGait, post infection day 27, hindlimb [cm] overlap_distance_hind 64555 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:157	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	extent of overlap between ipsilateral fore and hind paws during full stance (balance metric) as measured by DigiGait, post infection day 27, forelimb [cm] paw_placement_fore 64557 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:159	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	extent of overlap between ipsilateral fore and hind paws during full stance (balance metric) as measured by DigiGait, post infection day 27, hindlimb [cm] paw_placement_hind 64559 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:161	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	gait variability metric as measured by DigiGait, post infection day 27, forelimb ataxia_coefficient_fore 64561 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:163	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	gait variability metric as measured by DigiGait, post infection day 27, hindlimb ataxia_coefficient_hind 64563 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:165	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	distance between centroid of a paw at peak stance and a reference line drawn through transverse midline of mouse (kinetics metric) as measured by DigiGait, post infection day 27, forelimb [cm] midline_distance_fore 64565 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:167	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	distance between centroid of a paw at peak stance and a reference line drawn through transverse midline of mouse (kinetics metric) as measured by DigiGait, post infection day 27, hindlimb [cm] midline_distance_hind 64567 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:169	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	distance between centroid of a paw at peak stance and a reference line drawn through axis of mouse (kinetics metric) as measured by DigiGait, post infection day 27, forelimb [cm] axis_distance_fore 64569 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:171	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	distance between centroid of a paw at peak stance and a reference line drawn through axis of mouse (kinetics metric) as measured by DigiGait, post infection day 27, hindlimb [cm] axis_distance_hind 64571 left right	CC	4	both	4wks	N=1	2017

Brinkmeyer1:173	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	perpendicular distance between centroids of either set of axial paws during peak stance as measured by DigiGait, post infection day 27 [cm] stance_width 64573 forelimb hindlimb	CC	4	both	4wks	N=1	2017

Brinkmeyer1:175	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	stance width coefficient of variation as measured by DigiGait, post infection day 27 [%] stance_width_CV 64575 forelimb hindlimb	CC	4	both	4wks	N=1	2017

Brinkmeyer1:177	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	ratio of left and right stance durations as measured by DigiGait, post infection day 27 [ratio] stance_factor 64577 forelimb hindlimb	CC	4	both	4wks	N=1	2017

Brinkmeyer1:179	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	stride width variability as measured by DigiGait, post infection day 27 [cm] stride_width_var 64579 forelimb hindlimb	CC	4	both	4wks	N=1	2017

Brinkmeyer1:181	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	angle made between left and right paws as a function of stride length and stance width as measured by DigiGait, post infection day 27 [deg] step_angle 64581 forelimb hindlimb	CC	4	both	4wks	N=1	2017

Brinkmeyer1:183	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	step angle variability (standard deviation of step angle for set of strides recorded) as measured by DigiGait, post infection day 27 [deg] step_angle_SD 64583 forelimb hindlimb	CC	4	both	4wks	N=1	2017

Brinkmeyer1:185	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	step angle coefficient of variation as measured by DigiGait, post infection day 27 [%] step_angle_CV 64585 forelimb hindlimb	CC	4	both	4wks	N=1	2017

Brinkmeyer1:187	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	length of forelimb steps as measured by foot print analysis, post infection [cm] length_fore 64587 wk 7 wk 8 wk 9 wk 10 wk 11 wk 12 wk 13	CC	5	both	4wks	N=2	2017

Brinkmeyer1:194	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	width of forelimb steps as measured by foot print analysis, post infection [cm] width_fore 64594 wk 7 wk 8 wk 9 wk 10 wk 11 wk 12 wk 13	CC	5	both	4wks	N=2	2017

Brinkmeyer1:201	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	length of hindlimb steps as measured by foot print analysis, post infection [cm] length_hind 64601 wk 7 wk 8 wk 9 wk 10 wk 11 wk 12 wk 13	CC	5	both	4wks	N=2	2017

Brinkmeyer1:208	Brinkmeyer1	gait analysis	Theiler's murine encephalomyelitis virus	width of hindlimb steps as measured by foot print analysis, post infection [cm] width_hind 64608 wk 7 wk 8 wk 9 wk 10 wk 11 wk 12 wk 13	CC	5	both	4wks	N=2	2017

Brinkmeyer1:215	Brinkmeyer1	rotarod	Theiler's murine encephalomyelitis virus	time to fall from accelerating rotarod, post infection wk 7 [s] rotarod 64615 trial 1 trial 2 trial 3 trial 4 trial 5 trial 6 trial 7 trial 8 trial 9	CC	5	both	4wks	N=2	2017

Brinkmeyer1

body weight

Theiler's murine encephalomyelitis virus

body weight, post infection [g] bw 64401 day 0 day 2 day 4 day 6 day 8 day 10 day 14 day 17 day 22 day 27 (6 more)...

CC

5

both

4wks

N=5

2017

Brinkmeyer1

health assessment

Theiler's murine encephalomyelitis virus

clinical score (0=normal, 6=moribund), post infection [score] clin_score 64417 day 0 day 2 day 4 day 6 day 8 day 12 day 18 day 24 day 29 day 34 (6 more)...

CC

5

both

4wks

N=5

2017

Brinkmeyer1

RNA expression profiling

Theiler's murine encephalomyelitis virus

TMEV transcript abundance (normalized), post infection TMEV 64433 day 7 day 28

CC

4

both

4wks

N=1

2017

Brinkmeyer1

open field test

Theiler's murine encephalomyelitis virus

number of seconds spent grooming, 10 min test, post infection wk 3 (manual assessment) [s] grooming 64435

CC

5

both

4wks

N=2

2017

Brinkmeyer1

open field test

Theiler's murine encephalomyelitis virus

number of times mouse reared, 10 min test, post infection wk 3 (manual assessment) [n] activity_rearing 64436

CC

5

both

4wks

N=2

2017

Brinkmeyer1

open field test

Theiler's murine encephalomyelitis virus

horizontal movement latency, 30 min test, post infection wk 3 [s] horiz_latency 64437 trial 1 trial 2

CC

4

both

4wks

N=2

2017

Brinkmeyer1

open field test

Theiler's murine encephalomyelitis virus

number of horizontal movements (beam breaks), 30 min test, post infection wk 3 [n] horiz_activity 64439 trial 1 trial 2

CC

4

both

4wks

N=2

2017

Brinkmeyer1

open field test

Theiler's murine encephalomyelitis virus

horizontal distance traveled, 30 min test, post infection wk 3 [cm] horiz_distance 64441 trial 1 trial 2

CC

4

both

4wks

N=2

2017

Brinkmeyer1

open field test

Theiler's murine encephalomyelitis virus

time spent moving horizontally, 30 min test, post infection wk 3 [s] horiz_time 64443 trial 1 trial 2

CC

4

both

4wks

N=2

2017

Brinkmeyer1

open field test

Theiler's murine encephalomyelitis virus

horizontal movement velocity, 30 min test, post infection wk 3 [cm/s] horiz_velocity 64445 trial 1 trial 2

CC

4

both

4wks

N=2

2017

Brinkmeyer1

open field test

Theiler's murine encephalomyelitis virus

number of vertical plane entries, 30 min test, post infection wk 3 [n] vert_activity 64447 trial 1 trial 2

CC

4

both

4wks

N=2

2017

Brinkmeyer1

open field test

Theiler's murine encephalomyelitis virus

number of vertical plane episodes, 30 min test, post infection wk 3 [n] vert_episodes 64449 trial 1 trial 2

CC

4

both

4wks

N=2

2017

Brinkmeyer1

open field test

Theiler's murine encephalomyelitis virus

time spent vertical, 30 min test, post infection wk 3 [s] vert_time 64451 trial 1 trial 2

CC

4

both

4wks

N=2

2017

Brinkmeyer1

open field test

Theiler's murine encephalomyelitis virus

time spent resting, 30 min test, post infection wk 3 [s] resting 64453 trial 1 trial 2

CC

4

both

4wks

N=2

2017

Brinkmeyer1

open field test

Theiler's murine encephalomyelitis virus

number of center entries, 30 min test, post infection wk 3 [n] center_entries 64455 trial 1 trial 2

CC

4

both

4wks

N=2

2017

Brinkmeyer1

open field test

Theiler's murine encephalomyelitis virus

time spent in center, 30 min test, post infection wk 3 [s] center_time 64457 trial 1 trial 2

CC

4

both

4wks

N=2

2017

Brinkmeyer1

open field test

Theiler's murine encephalomyelitis virus

time spent in periphery, 30 min test, post infection wk 3 [s] periphery_time 64459 trial 1 trial 2

CC

4

both

4wks

N=2

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

number of steps included in analysis as measured by DigiGait, post infection day 27, forelimb [n] num_steps_fore 64461 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

number of steps included in analysis as measured by DigiGait, post infection day 27, hindlimb [n] num_steps_hind 64463 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

duration of swing phase (no paw contact with belt) as measured by DigiGait, post infection day 27, forelimb [s] swing_dur_fore 64465 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

duration of swing phase (no paw contact with belt) as measured by DigiGait, post infection day 27, hindlimb [s] swing_dur_hind 64467 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

percentage of total stride duration that paw is in air as measured by DigiGait, post infection day 27, forelimb [%] swing_stride_fore 64469 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

percentage of total stride duration that paw is in air as measured by DigiGait, post infection day 27, hindlimb [%] swing_stride_hind 64471 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

duration of braking phase as measured by DigiGait, post infection day 27, forelimb [s] brake_dur_fore 64473 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

duration of braking phase as measured by DigiGait, post infection day 27, hindlimb [s] brake_dur_hind 64475 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

percentage of total stride duration that paw is in braking phase as measured by DigiGait, post infection day 27, forelimb [%] brake_stride_fore 64477 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

percentage of total stride duration that paw is in braking phase as measured by DigiGait, post infection day 27, hindlimb [%] brake_stride_hind 64479 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

percentage of stance phase that paw is in braking phase as measured by DigiGait, post infection day 27, forelimb [%] brake_stance_fore 64481 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

percentage of stance phase that paw is in braking phase as measured by DigiGait, post infection day 27, hindlimb [%] brake_stance_hind 64483 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

duration of propulsion phase as measured by DigiGait, post infection day 27, forelimb [s] propel_dur_fore 64485 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

duration of propulsion phase as measured by DigiGait, post infection day 27, hindlimb [s] propel_dur_hind 64487 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

percentage of total stride duration that paw is in propulsion phase as measured by DigiGait, post infection day 27, forelimb [%] propel_stride_fore 64489 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

percentage of total stride duration that paw is in propulsion phase as measured by DigiGait, post infection day 27, hindlimb [%] propel_stride_hind 64491 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

percentage of stance phase that paw is in propulsion phase as measured by DigiGait, post infection day 27, forelimb [%] propel_stance_fore 64493 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

percentage of stance phase that paw is in propulsion phase as measured by DigiGait, post infection day 27, hindlimb [%] propel_stance_hind 64495 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

percentage of total stride duration that paw is in any contact with treadmill belt as measured by DigiGait, post infection day 27, forelimb [%] stance_stride_fore 64497 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

percentage of total stride duration that paw is in any contact with treadmill belt as measured by DigiGait, post infection day 27, hindlimb [%] stance_stride_hind 64499 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

ratio of swing phase time to stance phase time as measured by DigiGait, post infection day 27, forelimb [ratio] stance_swing_fore 64501 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

ratio of swing phase time to stance phase time as measured by DigiGait, post infection day 27, hindlimb [ratio] stance_swing_hind 64503 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

duration of one complete stride for one paw (equal to stance and swing durations) as measured by DigiGait, post infection day 27, forelimb [s] stride_dur_fore 64505 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

duration of one complete stride for one paw (equal to stance and swing durations) as measured by DigiGait, post infection day 27, hindlimb [s] stride_dur_hind 64507 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

number of times each second (cadence) that a paw takes a complete stride as measured by DigiGait, post infection day 27, forelimb [n/s] stride_freq_fore 64509 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

number of times each second (cadence) that a paw takes a complete stride as measured by DigiGait, post infection day 27, hindlimb [n/s] stride_freq_hind 64511 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

spatial length that a paw traverses through a given stride as measured by DigiGait, post infection day 27, forelimb [cm] stride_length_fore 64513 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

spatial length that a paw traverses through a given stride as measured by DigiGait, post infection day 27, hindlimb [cm] stride_length_hind 64515 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

stride length variability as measured by DigiGait, post infection day 27, forelimb [cm] stride_length_var_fore 64517 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

stride length variability as measured by DigiGait, post infection day 27, hindlimb [cm] stride_length_var_hind 64519 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

stride length coefficient of variation as measured by DigiGait, post infection day 27, forelimb [%] stride_length_CV_fore 64521 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

stride length coefficient of variation as measured by DigiGait, post infection day 27, hindlimb [%] stride_length_CV_hind 64523 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

angle that paw makes with long axis of direction of motion of mouse as measured by DigiGait, post infection day 27, forelimb [deg] paw_angle_fore 64525 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

angle that paw makes with long axis of direction of motion of mouse as measured by DigiGait, post infection day 27, hindlimb [deg] paw_angle_hind 64527 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

standard deviation of paw angle for set of strides recorded as measured by DigiGait, post infection day 27, forelimb [deg] paw_angle_SD_fore 64529 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

standard deviation of paw angle for set of strides recorded as measured by DigiGait, post infection day 27, hindlimb [deg] paw_angle_SD_hind 64531 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

maximal paw area as measured by DigiGait, post infection day 27, forelimb [cm²] paw_area_max_fore 64533 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

maximal paw area as measured by DigiGait, post infection day 27, hindlimb [cm²] paw_area_max_hind 64535 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

standard deviation of paw area for set of strides recorded as measured by DigiGait, post infection day 27, forelimb [cm²] paw_area_SD_fore 64537 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

standard deviation of paw area for set of strides recorded as measured by DigiGait, post infection day 27, hindlimb [cm²] paw_area_SD_hind 64539 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

ratio of forelimb stepping to fore limb stepping frequency (coordination metric) as measured by DigiGait, post infection day 27, forelimb [ratio] gait_symmetry_fore 64541 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

ratio of forelimb stepping to hind limb stepping frequency (coordination metric) as measured by DigiGait, post infection day 27, hindlimb [ratio] gait_symmetry_hind 64543 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

maximal rate of change in paw area in contact with treadmill belt during braking phase as measured by DigiGait, post infection day 27, forelimb [cm²/s] max_area_break_fore 64545 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

maximal rate of change in paw area in contact with treadmill belt during braking phase as measured by DigiGait, post infection day 27, hindlimb [cm²/s] max_area_break_hind 64547 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

maximal rate of change in paw area in contact with treadmill belt during propulsion phase as measured by DigiGait, post infection day 27, forelimb [cm²/s] max_area_propuls_fore 64549 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

maximal rate of change in paw area in contact with treadmill belt during propulsion phase as measured by DigiGait, post infection day 27, hindlimb [cm²/s] max_area_propuls_hind 64551 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

overlap extent of ipsilateral fore and hind paws as measured by DigiGait, post infection day 27, forelimb [cm] overlap_distance_fore 64553 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

overlap extent of ipsilateral fore and hind paws as measured by DigiGait, post infection day 27, hindlimb [cm] overlap_distance_hind 64555 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

extent of overlap between ipsilateral fore and hind paws during full stance (balance metric) as measured by DigiGait, post infection day 27, forelimb [cm] paw_placement_fore 64557 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

extent of overlap between ipsilateral fore and hind paws during full stance (balance metric) as measured by DigiGait, post infection day 27, hindlimb [cm] paw_placement_hind 64559 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

gait variability metric as measured by DigiGait, post infection day 27, forelimb ataxia_coefficient_fore 64561 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

gait variability metric as measured by DigiGait, post infection day 27, hindlimb ataxia_coefficient_hind 64563 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

distance between centroid of a paw at peak stance and a reference line drawn through transverse midline of mouse (kinetics metric) as measured by DigiGait, post infection day 27, forelimb [cm] midline_distance_fore 64565 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

distance between centroid of a paw at peak stance and a reference line drawn through transverse midline of mouse (kinetics metric) as measured by DigiGait, post infection day 27, hindlimb [cm] midline_distance_hind 64567 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

distance between centroid of a paw at peak stance and a reference line drawn through axis of mouse (kinetics metric) as measured by DigiGait, post infection day 27, forelimb [cm] axis_distance_fore 64569 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

distance between centroid of a paw at peak stance and a reference line drawn through axis of mouse (kinetics metric) as measured by DigiGait, post infection day 27, hindlimb [cm] axis_distance_hind 64571 left right

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

perpendicular distance between centroids of either set of axial paws during peak stance as measured by DigiGait, post infection day 27 [cm] stance_width 64573 forelimb hindlimb

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

stance width coefficient of variation as measured by DigiGait, post infection day 27 [%] stance_width_CV 64575 forelimb hindlimb

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

ratio of left and right stance durations as measured by DigiGait, post infection day 27 [ratio] stance_factor 64577 forelimb hindlimb

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

stride width variability as measured by DigiGait, post infection day 27 [cm] stride_width_var 64579 forelimb hindlimb

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

angle made between left and right paws as a function of stride length and stance width as measured by DigiGait, post infection day 27 [deg] step_angle 64581 forelimb hindlimb

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

step angle variability (standard deviation of step angle for set of strides recorded) as measured by DigiGait, post infection day 27 [deg] step_angle_SD 64583 forelimb hindlimb

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

step angle coefficient of variation as measured by DigiGait, post infection day 27 [%] step_angle_CV 64585 forelimb hindlimb

CC

4

both

4wks

N=1

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

length of forelimb steps as measured by foot print analysis, post infection [cm] length_fore 64587 wk 7 wk 8 wk 9 wk 10 wk 11 wk 12 wk 13

CC

5

both

4wks

N=2

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

width of forelimb steps as measured by foot print analysis, post infection [cm] width_fore 64594 wk 7 wk 8 wk 9 wk 10 wk 11 wk 12 wk 13

CC

5

both

4wks

N=2

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

length of hindlimb steps as measured by foot print analysis, post infection [cm] length_hind 64601 wk 7 wk 8 wk 9 wk 10 wk 11 wk 12 wk 13

CC

5

both

4wks

N=2

2017

Brinkmeyer1

gait analysis

Theiler's murine encephalomyelitis virus

width of hindlimb steps as measured by foot print analysis, post infection [cm] width_hind 64608 wk 7 wk 8 wk 9 wk 10 wk 11 wk 12 wk 13

CC

5

both

4wks

N=2

2017

Brinkmeyer1

rotarod

Theiler's murine encephalomyelitis virus

time to fall from accelerating rotarod, post infection wk 7 [s] rotarod 64615 trial 1 trial 2 trial 3 trial 4 trial 5 trial 6 trial 7 trial 8 trial 9

CC

5

both

4wks

N=2

2017

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