Wiltshire3: Drug study: Neurobiochemical analytes in response to chronic fluoxetine treatment in males of 30 inbred mouse strains (2011)
Benton CS, Miller BH, Skwerer S, Suzuki O, Schultz LE, Cameron MD, Marron JS, Pletcher MT, Wiltshire T. Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains.
Psychopharmacology (Berl). 2012 May;221(2):297-315. Epub 2011 Nov 24.
PubMed 22113448FullText
Notes The *_index values were derived from the related strain means for flouoxetine-treated and control.
Nmice has been set to 3 for these, and SD to 0 since no error statistic is available.
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Behavior phenotype data see Pletcher1
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Behavior phenotype data (fluoxetine study) see Wiltshire2
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Neurobiochemical analyte data (this project) Wiltshire3
Acknowledgements
Funding provided by NIH MH077251 and MH084528; State of Florida
In fulfillment of NIH requirements that all information is made promptly and freely available to the research community, data are deposited in the MPD when complete.
Project type
Phenotype strain survey data set
MPD identifiers
Wiltshire3 MPD:381
Data changelog
No updates/corrections.
Initial release date: 12/2011.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Neurobiochemical analytes thought to affect anxiety and mood disorders were measured to identify biomarkers of anti-depressant responses by comparing analyte levels to behavioral phenotypes
(Wiltshire2)
between two cohorts: 1) vehicle (control), and 2)
fluoxetine (chronic treatment).
Procedures conducted:
• biomarker quantification
Brain tissue survey of 30 biochemical analytes. Fluoxetine-treated vs. control. 21d.
Mice: inbred
30 strains
♂
age 10-11wks
2 experimental groups