Wiltshire3: Drug study: Neurobiochemical analytes in response to chronic fluoxetine treatment in males of 30 inbred mouse strains (2011)
Benton CS, Miller BH, Skwerer S, Suzuki O, Schultz LE, Cameron MD, Marron JS, Pletcher MT, Wiltshire T. Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains.
Psychopharmacology (Berl). 2012 May;221(2):297-315. Epub 2011 Nov 24.
Notes The *_index values were derived from the related strain means for flouoxetine-treated and control.
Nmice has been set to 3 for these, and SD to 0 since no error statistic is available.
Behavior phenotype data see Pletcher1
Behavior phenotype data (fluoxetine study) see Wiltshire2
Neurobiochemical analyte data (this project) Wiltshire3
Funding provided by NIH MH077251 and MH084528; State of Florida
In fulfillment of NIH requirements that all information is made promptly and freely available to the research community, data are deposited in the MPD when complete.
Phenotype strain survey data set
Initial release date: 12/2011.
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Neurobiochemical analytes thought to affect anxiety and mood disorders were measured to identify biomarkers of anti-depressant responses by comparing analyte levels to behavioral phenotypes
between two cohorts: 1) vehicle (control), and 2)
fluoxetine (chronic treatment).
• biomarker quantification
Brain tissue survey of 30 biochemical analytes. Fluoxetine-treated vs. control. 21d.
2 experimental groups