Wiltshire3: Drug study: Neurobiochemical analytes in response to chronic fluoxetine treatment in males of 30 inbred mouse strains (2011)

Benton CS, Miller BH, Skwerer S, Suzuki O, Schultz LE, Cameron MD, Marron JS, Pletcher MT, Wiltshire T. Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains. Psychopharmacology (Berl). 2012 May;221(2):297-315. Epub 2011 Nov 24.   PubMed 22113448     FullText

The *_index values were derived from the related strain means for flouoxetine-treated and control. Nmice has been set to 3 for these, and SD to 0 since no error statistic is available.

Wiltshire3 downloads
• Download Wiltshire3 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators Tim Wiltshire       University of North Carolina,  Chapel Hill, NC
Mathew T Pletcher       Pfizer Global Research and Development,  Groton, CT
Participants Benton CS, Miller BH, Skwerer S, Suzuki O, Schultz LE, Cameron MD, Marron JS
ContactTim Wiltshire     timw@unc.edu     Lab web site
Part of a series: • Behavior phenotype data   see Pletcher1
• Behavior phenotype data (fluoxetine study)   see Wiltshire2
• Neurobiochemical analyte data   (this project) Wiltshire3
AcknowledgementsFunding provided by NIH MH077251 and MH084528; State of Florida
In fulfillment of NIH requirements that all information is made promptly and freely available to the research community, data are deposited in the MPD when complete.
Project type Phenotype strain survey data set
MPD identifiersWiltshire3     MPD:381
Data changelog No updates/corrections.       Initial release date: 12/2011.
Formatted citation
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Neurobiochemical analytes thought to affect anxiety and mood disorders were measured to identify biomarkers of anti-depressant responses by comparing analyte levels to behavioral phenotypes (Wiltshire2) between two cohorts: 1) vehicle (control), and 2) fluoxetine (chronic treatment).

Procedures conducted:
• biomarker quantification  Brain tissue survey of 30 biochemical analytes. Fluoxetine-treated vs. control. 21d.

Mice: inbred   30 strains   ♂   age 10-11wks   2 experimental groups