Source Mice originated from a colony maintained by Gary Churchill at The Jackson Laboratory in Bar Harbor, Maine. Mice were bred at the UNC Hillsborough vivarium from 2008-2010 and bred at the UNC Genetic Medicine Building vivarium from 2010-2012. Ages 3 wks of age (at weaning) Feed
Purina Prolab RMH3000, provided ad libitum. Mouse chow was supplemented with Fenbendazole two weeks before and two weeks after transportation to the GMB facility to eliminate possible pinworms. Selemectin treatment was dropped onto the coats of mice before transfer to GMB to remove mites.
Water Provided ad libitum Temperature 20-24°C Humidity 40-50% Housing Mice were housed in standard 20x30 cm ventilated polysulfone cages Bedding Bed-O-Cob Photoperiod 14:10h light:dark cycle (lights on at 0600h) Testing period 2008-2012 Care and Use Animal rearing and breeding was conducted in strict compliance with the Guide for the Care and Use of Laboratory Animals (Institute of Laboratory Animals Resources, National Research Council 1996)