Schoonjans1 animal documentation

Changes in bile acid pool size and composition in plasma, feces and liver; body and organ weights; and blood glucose levels in male mice of 34 BXD recombinant inbred strains and two parental strains fed chow or high-fat diet   (2022)

Schoonjans K, Li H, Perino A, Huang Q, von Alvensleben G, Banaei-Esfahani A, Auwerx J
With: Velazquez-Villegas LA, Gariani K, Ivanisevic J, Korbelius M, Li X, Rapin A, Bou Sleiman M




Animal Documentation

Source of Mice: BXD mice strains were acquired from The University of Tennessee Health Science Center (Memphis, TN, USA)

Age (wks): 8-29 wks at testing

Breeding: Mice were bred for multiple generations at the Center of PhenoGenomics (SV-CPG) based at the École Polytechnique Fédérale de Lausanne (EPFL), before being integrated into the study

Test Facility: Center of PhenoGenomics (SV-CPG) at the École Polytechnique Fédérale de Lausanne (EPFL)

Feed: Standard Rodent chow (CD) or High-fat diet (HFD) at 8 weeks of age ad libitum (see procedure 1 for details of diet)

Water: Water ad libitum

Temperature (°C): 22 +/- 2

Humidity (%): 50 +/- 10

Light / Dark Cycle: 12:12h

Health Status and Monitoring: Gross external inspection of all mice was performed daily by experienced animal caretakers

Care and Use Statement: All animal experiments were approved by the Swiss cantonal veterinary authorities of Vaud under license 2257.2