Source Female C57BL/6J mice hemizygous for the 5XFAD transgene (B6.Cg-Tg(APPSweFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax, Stock No. #34848-JAX) were mated to males from the BXD genetic reference panel (from University of Tennessee Health Science Center). As female B6.5XFAD mice are hemizygous, transgenic (ADtg) and non-transgenic (Ntg) F1 mice are generated. Ages Mice tested at 8-65 wks of age Feed
Not specified, provided ad libitum
Water Provided ad libitum Temperature Not specified Humidity Not specified Housing
Mice were group housed at the University of Tennessee Health Science Center
Photoperiod 12:12h Care and Use Experiments were carried out in accordance with the standards of the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC), as well as the recommendations of the National Institutes of Health Guide for the Care and Use of Laboratory Animals. The protocol was approved by the Institutional Animal Care and Use Committee (IACUC) at the University of Tennessee Health Science Center.