Mogil3: Spared nerve injury induced mechanical allodynia in 18 inbred strains of mice (2012)

Sorge RE, Trang T, Dorfman R, Smith SB, Beggs S, Ritchie J, Austin JS, Zaykin DV, Vander Meulen H, Costigan M, Herbert TA, Yarkoni-Abitbul M, Tichauer D, Livneh J, Gershon E, Zheng M, Tan K, et al. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med. 2012 Mar 25;18(4):595-9. doi: 10.1038/nm.2710.   PubMed 22447075     FullText


         
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Investigators Jeffrey S Mogil       McGill University,  Montreal, Quebec CANADA
Michael W Salter       University of Toronto,  Toronto CANADA
Participants Sorge RE, Trang T
ContactJeffrey S Mogil     jeffrey.mogil@mcgill.ca     Lab web site
AcknowledgementsFunding provided by National Institutes of Health, Louise and Alan Edwards Foundation, Canada Research Chairs program, Howard Hughes Medical Institute, Canadian Institutes of Health Research, Krembil Foundation, Ontario Research Foundation, Algynomics/Pfizer, AstraZeneca–Alan Edwards Centre for Research on Pain, Canadian Institutes of Health
Project type Phenotype strain survey data set
MPD identifiersMogil3     MPD:480
Data changelog No updates/corrections.       Initial release date: 06/2013.
Formatted citation
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Procedures conducted:
• nociception assay  von Frey nociception test, baseline and after spared nerve injury (SNI) surgery as a hypersensitizer.

Mice: inbred   18 strains   ♀♂   age 7-12wks   1 experimental group

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Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
    Mogil3 nociception assay (none) 50% hindpaw withdrawal threshold, von Frey test   [g]  baseline   48001 inbred 18 both 7-12wks N=3
    Mogil3 nociception assay (none) percentage of maximum hindpaw mechanical allodynia over 28 days after spared nerve injury   [%]  allodynia   48002 inbred 18 both 7-12wks N=3
    All boxes            


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