Acclimation and testing periods
Supplier Male AKR/J and 129×1/SvJ mice were obtained from The Jackson Laboratory (Bar Harbor, ME, USA). Initial breeding pairs of C57BL/6J, DBA/2J, A/J and chromosome substitution strain- C57BL/6J-Chr 1A/J/NaJ (CSS1), were obtained from The Jackson Laboratory (JAX®, Bar Harbor, ME, USA). Progenies from institutional breeding program were used in the study. Ages Experiments were conducted when the mice aged to 5–7 months old. Feed Mice were given unrestricted access to feed obtained from Special Diet Services (SDS; Witham, Essex, United Kingdom). This diet contains 3.4% oil, 18.8% protein, 60.3% carbohydrate, and 3.7% fiber, in addition to 3% minerals, vitamins, and amino acids. Water Ad libitum Housing Mice were group housed (2–4 animals/cage; Macrolon type II; no. 1284 L) Photoperiod 12:12 h dark–light cycle (white light on: 2:00–14:00 with light intensity of 60 lux; lights off at 1300 h) Temperature 22 +/- 2.0°C Health status All experimental procedures were approved by the ethical committee for animal experimentation of the Utrecht University, the Netherlands.