Johnson1: Assessment of age-dependent hearing loss in 51 inbred strains of mice (2000)

Zheng QY, Johnson KR, Erway LC. Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses. Hear Res. 1999 Apr;130(1-2):94-107.   PubMed 10320101  


         
Notes
The analysis unit for this project is strain / sex / age group (where age group is either "young" or "old"). Strain / sex / age groups having less than 5 animals have been omitted from the MPD data set.

Johnson1 downloads
• Download Johnson1 project data set     one row per animal, one column per trait
• Download Johnson1 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Kenneth R Johnson       The Jackson Laboratory Bar Harbor, ME
Lawrence C Erway       University of Cincinnati Cincinnati, OH
Qing Yin Zheng       Case Western Reserve University School of Medicine Cleveland, OH
ContactKenneth R Johnson     ken.johnson@jax.org     Lab web site
AcknowledgementsFunding provided by NIH DC62108, CA34196
Project type Phenotype strain survey data set
MPD identifiersJohnson1     MPD:14
Data changelog 2 updates/corrections.       Initial release date: 02/2001.
Formatted citation
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Four ABR threshold measurements were taken per mouse, in response to four different audible sounds. The first measurement was for a click; the second for an 8kHz pip; the third for a 16kHz pip; the fourth for a 32kHz pip. The results are presented here broken down by mouse age. Early (young group) onset of hearing impairment occurs at age < 13 weeks. Later (old group) onset of hearing impairment occurs at age ≥ 13 weeks.

Summary of procedures that were conducted
• ABR test Auditory brainstem response.
Mice: inbred   51 strains   ♀♂   age 3-12wks and 15-72wks   2 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Johnson1 1402 ABR test (none) auditory brainstem response (ABR) threshold, 3-12 wk old group, sound pressure level   [dB]     young group:    click    8kHz pip    16kHz pip    32kHz pip inbred 28 both 3-12wks N=7
    Johnson1 1407 ABR test (none) auditory brainstem response (ABR) threshold, 15-72 wk old group, sound pressure level   [dB]     old group:    click    8kHz pip    16kHz pip    32kHz pip inbred 21 both 15-72wks N=11
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