Jaxwest2: Neoplasia induction in NOD.CB17-Prkdcscid/J female mice by passage of live tumor cells (HT29) (2007)

Jackson Laboratory   Yan Yang   With: Yang Y, Rodriguez R, Braun M, Clary D

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Institutional authorship Jackson Laboratory     Lab web site
Investigators Yan Yang       The Jackson Laboratory,  Bar Harbor, ME
Participants Yang Y, Rodriguez R, Braun M, Clary D
ContactYan Yang     yan.yang@jax.org     Lab web site
Affiliated CenterJAX In Vivo Services
Project type One-strain study
MPD identifiersJaxwest2     MPD:257
Data changelog No updates/corrections.       Initial release date: 06/2007.
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Purpose: To provide normative data for testing biologically-active compounds in immunodeficient female NOD.CB17-Prkdcscid/J strain. This strain is an excellent host for xenografts, including the human colorectal adenocarcinoma cell line, HT-29, used here for tumor induction.

By posting this data, JAX® In Vivo Services contributes to community research resources and fulfills an agreement with clients to make normative data public.

Protocol Animal documentation

Available download:   Jaxwest2.xls

    The data set contains these columns:
    birth date of birth  
    arrival date of arrival at test facility  
    cage_code cage code at test facility  
    HT29_inj tumor cells (HT29) injected  
    exp_group experimental group: Control w/out vehicle; Control w/vehicle; Test Group (pre-treatment data only)  
    bw_X body weight on Day X (after arrival) g
    bw_chg_X change in body weight from Day 12 to Day X %
    tumor_L_X tumor length on Day X mm
    tumor_W_X tumor width on Day X mm
    tumor_H_X tumor height on Day X mm
    tumor_vol_X tumor volume on Day X mm3
    tumor_chg_X change in tumor volume from 1 wk after HT29 injection (Day 19) to Day X %
    tumor_wt_44 tumor weight at necropsy (Day 44) g
    survival_500 number of days after HT29 injection that tumor volume reached 500 mm3 n
    survival_1500 number of days after HT29 injection that tumor volume reached 1500 mm3 n
    X = Each of these measurements is replicated for test Day X (see protocol for more information).