Source of Mice: Mice carrying the human transgene for cholesterol ester transfer protein (CETP) were obtained from The Jackson Laboratory (Stock number 003904); mice carrying the human ApoE*3 Leiden variant were provided by Dr L. Havekes at Leiden University Medical Center, Leiden, The Netherlands. Common inbred and recombinant inbred of the Hybrid Mouse Diversity Panel were obtained from The Jackson Laboratory.
Age (wks): 23-25wks
Breeding: Transgenic animals were bred to produce a C57BL/6J strain carrying both human APOE*3Leiden and human transgenes. Males transgenic for both transgenes were bred to females of common inbred and recombinant inbred strains of the Hybrid Mouse Diversity Panel.
Feed: Chow or experimental diet
Water: Water ad libitum
Temperature (°C): Not specified
Humidity (%): Not specified
Light / Dark Cycle: 12:12h (lights on 0600h)
Care and Use Statement: All experiments were conducted according to relevant national and international guidelines and was approved by the UCLA Animal Research Committee, the UCLA IACUC.