Gershenfeld1: Drug study: Imipramine effects in 12 inbred strains of mice measured by tail suspension, light-dark transition, and open field tests (2003)

Liu X, Gershenfeld HK. Genetic differences in the tail-suspension test and its relationship to imipramine response among 11 inbred strains of mice. Biol Psychiatry. 2001 Apr 1;49(7):575-81.   PubMed 11297714  

Liu X, Gershenfeld HK. An exploratory factor analysis of the Tail Suspension Test in 12 inbred strains of mice and an F2 intercross. Brain Res Bull. 2003 May 15; 60(3): 223-31.   PubMed 12754084  

A supplemental data set (5 strains) is also available. It is connected with the publication Liu X, Peprah D, Gershenfeld HK   Tail-suspension induced hyperthermia: a new measure of stress reactivity.

Gershenfeld1 downloads
• Download Gershenfeld1 project data set     animal data, as uploaded
• Download Gershenfeld1 animal data matrix     with factor-related expansion applied as necessary
• Download Gershenfeld1 strain means, SD, N, etc.     one row per strain/sex/measure
• Gershenfeld1 supplementary data
Investigators Howard K Gershenfeld       University of Texas - Southwestern,  Dallas, TX
Participants Liu X
ContactHoward K Gershenfeld
AcknowledgementsFunding provided by NIH MH58882; National Association for Research on Schizophrenia and Depression Young Investigators Award; Southwestern Medical Foundation; KZA Hope Fund
Project type Phenotype strain survey data set
MPD identifiersGershenfeld1     MPD:162
Data changelog No updates/corrections.       Initial release date: 07/2007.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An investigation of stress response and sensitivity to antidepressant/anxiolytic effect of imipramine. Animals were evaluated for "stress reactivity" using the tail suspension test. They were measured for "exploratory fear" behavior using the light-dark transition and open field tests. Imipramine was administered to alleviate stress arising from immobility. There were two cohorts tested at baseline and again following i.p. injection: 1) controls with saline i.p.; 2) treated with imipramine 30 mg/kg body weight i.p.

Procedures conducted:
• tail suspension test  Immobility. Baseline (saline) vs. imipramine i.p. 6 min test.
• light-dark box  Anxiety-related behavior. Baseline (saline) vs. imipramine i.p. 10 min test.
• open field test  Locomotor activity, exploratory and anxiety-related behavior. Baseline (saline) vs. imipramine i.p.

Mice: inbred   12 strains   ♂   age 5-10wks   2 experimental groups