Project measure / variable:   GMC05   PPI_global

ID, description, units MPD:55435   PPI_global   percentage prepulse inhibition (PPI) evoked by 110 dB sound pressure level with global prepulse stimulus   [%]  
Data set, strains GMC05   inbred w/CC8   8 strains     sex: both     age: 9-10wks
Procedure acoustic startle test
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  STRAIN COMPARISON PLOT
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GMC05 - percentage prepulse inhibition (PPI) evoked by 110 dB sound pressure level with global prepulse stimulus



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means37.7   % 36.2   %
Median of the strain means39.2   % 34.5   %
SD of the strain means± 25.8 ± 19.9
Coefficient of variation (CV)0.684 0.551
Min–max range of strain means-10.4   –   78.5   % 5.64   –   67.0   %
Mean sample size per strain17.5   mice 17.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 272.3916 272.3916 0.6906 0.4067
strain 7 112499.199 16071.3141 40.7475 < 0.0001
sex:strain 7 8084.0982 1154.8712 2.9281 0.0057
Residuals 261 102941.4913 394.4118


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 78.5 9.56   16 2.39 0.122 57.5, 89.9 1.58
129S1/SvImJ m 67.0 9.45   16 2.36 0.141 46.7, 85.7 1.55
A/J f -10.4 35.3   16 8.83 -3.39 -86.0, 36.5 -1.86
A/J m 5.64 24.1   16 6.03 4.27 -38.2, 46.3 -1.53
C57BL/6J f 53.5 10.6   16 2.64 0.198 28.7, 70.7 0.61
C57BL/6J m 55.3 9.42   16 2.35 0.17 39.5, 72.5 0.96
CAST/EiJ f 48.5 11.8   19 2.72 0.244 26.2, 66.4 0.42
CAST/EiJ m 45.4 15.3   18 3.62 0.338 11.7, 71.5 0.46
NOD/ShiLtJ f 40.3 16.0   18 3.76 0.396 8.1, 63.7 0.1
NOD/ShiLtJ m 21.8 21.0   16 5.26 0.964 -13.3, 57.5 -0.72
NZO/HlLtJ f 20.7 18.9   17 4.58 0.91 -9.9, 45.8 -0.66
NZO/HlLtJ m 25.1 23.0   17 5.57 0.914 -5.6, 57.1 -0.56
PWK/PhJ f 38.2 20.6   20 4.61 0.539 -18.0, 65.3 0.02
PWK/PhJ m 27.1 13.1   22 2.8 0.483 -1.1, 54.3 -0.46
WSB/EiJ f 32.6 31.3   18 7.39 0.962 -31.8, 61.8 -0.2
WSB/EiJ m 42.0 25.6   16 6.39 0.608 -13.8, 66.4 0.29


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 78.5125 4.965 88.289 68.736
129S1/SvImJ m 66.9938 4.965 76.7702 57.2173
A/J f -10.4125 4.965 -0.636 -20.189
A/J m 5.6438 4.965 15.4202 -4.1327
C57BL/6J f 53.4562 4.965 63.2327 43.6798
C57BL/6J m 55.3125 4.965 65.089 45.536
CAST/EiJ f 48.5211 4.5562 57.4925 39.5496
CAST/EiJ m 45.4111 4.681 54.6284 36.1938
NOD/ShiLtJ f 40.2944 4.681 49.5118 31.0771
NOD/ShiLtJ m 21.8188 4.965 31.5952 12.0423
NZO/HlLtJ f 20.7471 4.8167 30.2316 11.2625
NZO/HlLtJ m 25.1294 4.8167 34.614 15.6449
PWK/PhJ f 38.2 4.4408 46.9443 29.4557
PWK/PhJ m 27.1182 4.2341 35.4556 18.7808
WSB/EiJ f 32.5889 4.681 41.8062 23.3716
WSB/EiJ m 42.0437 4.965 51.8202 32.2673


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 72.7531 3.5108 79.6661 65.8401
A/J both -2.3844 3.5108 4.5286 -9.2974
C57BL/6J both 54.3844 3.5108 61.2974 47.4714
CAST/EiJ both 46.9661 3.2661 53.3974 40.5348
NOD/ShiLtJ both 31.0566 3.4118 37.7748 24.3384
NZO/HlLtJ both 22.9382 3.4059 29.6448 16.2316
PWK/PhJ both 32.6591 3.0679 38.7001 26.6181
WSB/EiJ both 37.3163 3.4118 44.0345 30.5981




  GWAS USING LINEAR MIXED MODELS