|
brain_DZ8 brain diazepam and metabolite concentration, 30 min post-injection
, dose: 8 mg/kg
15501
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
7 |
9 |
8 |
9 |
8 |
12 |
8 |
8 |
8 |
6 |
8 |
12 |
8 |
8 |
8 |
|
brain_DZ16 brain diazepam and metabolite concentration, 30 min post-injection
, dose: 16 mg/kg
15502
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
7 |
9 |
8 |
8 |
8 |
12 |
7 |
8 |
8 |
7 |
8 |
12 |
8 |
8 |
8 |
|
brain_DZ20_b1 brain diazepam and metabolite concentration, <5 min post-injection, after rotarod
, trial block1
15503
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
|
|
14 |
14 |
14 |
10 |
14 |
|
|
|
12 |
10 |
|
|
14 |
|
horiz_DZ0 horizontal distance traveled, immediately to 15 min post-injection
, baseline
15504
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
8 |
6 |
8 |
8 |
8 |
12 |
8 |
8 |
8 |
5 |
8 |
12 |
7 |
6 |
8 |
|
horiz_DZ2 horizontal distance traveled, immediately to 15 min post-injection
, dose 2 mg/kg
15505
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
8 |
8 |
8 |
8 |
8 |
11 |
8 |
8 |
8 |
5 |
7 |
12 |
8 |
7 |
8 |
|
horiz_DZ4 horizontal distance traveled, immediately to 15 min post-injection
, dose 4 mg/kg
15506
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
8 |
8 |
8 |
8 |
8 |
12 |
8 |
8 |
8 |
5 |
8 |
12 |
8 |
7 |
8 |
|
horiz_DZ8 horizontal distance traveled, immediately to 15 min post-injection
, dose 8 mg/kg
15507
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
8 |
9 |
8 |
8 |
8 |
11 |
8 |
8 |
8 |
6 |
8 |
12 |
6 |
8 |
8 |
|
horiz_DZ16 horizontal distance traveled, immediately to 15 min post-injection
, dose 16 mg/kg
15508
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
8 |
9 |
8 |
8 |
8 |
11 |
8 |
8 |
8 |
7 |
8 |
12 |
8 |
7 |
8 |
|
vertical_DZ0 vertical (rearing) activity, immediately to 15 min post-injection
, baseline
15509
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
8 |
6 |
8 |
8 |
8 |
12 |
8 |
8 |
8 |
5 |
8 |
12 |
7 |
6 |
8 |
|
vertical_DZ2 vertical (rearing) activity, immediately to 15 min post-injection
, dose 2 mg/kg
15510
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
8 |
8 |
8 |
8 |
8 |
11 |
8 |
8 |
8 |
5 |
7 |
12 |
8 |
7 |
8 |
|
vertical_DZ4 vertical (rearing) activity, immediately to 15 min post-injection
, dose 4 mg/kg
15511
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
8 |
8 |
8 |
8 |
8 |
12 |
8 |
8 |
8 |
5 |
8 |
12 |
8 |
7 |
8 |
|
vertical_DZ8 vertical (rearing) activity, immediately to 15 min post-injection
, dose 8 mg/kg
15512
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
8 |
9 |
8 |
8 |
8 |
11 |
8 |
8 |
8 |
6 |
8 |
12 |
6 |
8 |
8 |
|
vertical_DZ16 vertical (rearing) activity, immediately to 15 min post-injection
, dose 16 mg/kg
15513
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
8 |
9 |
8 |
8 |
8 |
11 |
8 |
8 |
8 |
7 |
8 |
12 |
8 |
7 |
8 |
|
temp_DZ0 body temperature, 30 min post-injection
, baseline
15514
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
8 |
6 |
8 |
8 |
8 |
12 |
8 |
8 |
8 |
5 |
8 |
12 |
7 |
7 |
8 |
|
temp_DZ2 body temperature, 30 min post-injection
, dose 2 mg/kg
15515
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
8 |
8 |
8 |
8 |
8 |
12 |
8 |
8 |
8 |
5 |
7 |
12 |
8 |
8 |
8 |
|
temp_DZ4 body temperature, 30 min post-injection
, dose 4 mg/kg
15516
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
8 |
8 |
8 |
8 |
8 |
12 |
8 |
8 |
8 |
5 |
8 |
12 |
8 |
8 |
8 |
|
temp_DZ8 body temperature, 30 min post-injection
, dose 8 mg/kg
15517
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
8 |
9 |
8 |
8 |
8 |
12 |
8 |
8 |
8 |
6 |
8 |
12 |
6 |
8 |
8 |
|
temp_DZ16 body temperature, 30 min post-injection
, dose 16 mg/kg
15518
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
8 |
9 |
8 |
8 |
8 |
12 |
8 |
8 |
8 |
7 |
8 |
12 |
8 |
8 |
8 |
|
fall_DZ20_b1 latency to fall from 5 rpm rotarod, 0 min post-injection
, trial block1
15519
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
|
|
14 |
14 |
14 |
10 |
14 |
|
|
|
12 |
10 |
|
|
14 |
|
fall_DZ20_b2 latency to fall from 5 rpm rotarod, 0 min post-injection
, trial block2
15520
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
14 |
13 |
|
|
|
10 |
|
14 |
14 |
8 |
|
9 |
14 |
14 |
|
|
brain_DZ20_b2 brain diazepam and metabolite concentration, <5 min post-injection, after rotarod
, trial block2
15525
|
Female |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Male |
14 |
14 |
|
|
|
20 |
|
14 |
14 |
8 |
|
9 |
14 |
14 |
|
|