Project measure / variable:   Paigen2   CHOL_fat17

ID, description, units MPD:9909   CHOL_fat17   total cholesterol (plasma)   [mg/dL]  after 17wks on diet  
high-fat diet study
Data set, strains Paigen2   inbred w/CC7   41 strains     sex: both     age: 7-9wks
Procedure lipid profile
Ontology mappings

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  STRAIN COMPARISON PLOT
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Paigen2 - total cholesterol (plasma) after 17wks on diet



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested40 strains36 strains
Mean of the strain means268   mg/dL 297   mg/dL
Median of the strain means225   mg/dL 222   mg/dL
SD of the strain means± 189 ± 328
Coefficient of variation (CV)0.705 1.10
Min–max range of strain means102   –   1235   mg/dL 135   –   2134   mg/dL
Mean sample size per strain8.7   mice 8.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 9898.0246 9898.0246 1.0509 0.3058
strain 34 23219847.4839 682936.6907 72.5115 < 0.0001
sex:strain 34 2423247.7024 71271.9912 7.5674 < 0.0001
Residuals 523 4925779.7908 9418.317


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 222.0 35.6   10 11.2 0.16 190.0, 279.0 -0.24
129S1/SvImJ m 242.0 26.0   9 8.68 0.108 211.0, 284.0 -0.17
A/J f 557.0 189.0   10 59.9 0.34 305.0, 873.0 1.53
A/J m 509.0 293.0   8 104.0 0.576 291.0, 988.0 0.65
AKR/J f 186.0 105.0   12 30.4 0.567 125.0, 511.0 -0.43
BALB/cByJ f 166.0 18.4   11 5.54 0.111 134.0, 186.0 -0.54
BALB/cByJ m 194.0 40.1   8 14.2 0.206 156.0, 269.0 -0.31
BTBR T+ Itpr3tf/J f 178.0 22.0   8 7.79 0.124 137.0, 206.0 -0.48
BTBR T+ Itpr3tf/J m 198.0 53.4   7 20.2 0.27 149.0, 281.0 -0.3
BUB/BnJ f 225.0 62.8   10 19.9 0.28 157.0, 332.0 -0.23
BUB/BnJ m 158.0 36.8   5 16.5 0.233 114.0, 205.0 -0.42
C3H/HeJ f 238.0 38.5   10 12.2 0.162 187.0, 293.0 -0.16
C3H/HeJ m 217.0 52.2   8 18.5 0.241 119.0, 298.0 -0.24
C57BL/10J f 144.0 23.8   9 7.93 0.165 114.0, 194.0 -0.66
C57BL/10J m 172.0 29.1   10 9.2 0.169 122.0, 222.0 -0.38
C57BL/6J f 200.0 37.5   10 11.9 0.188 125.0, 262.0 -0.36
C57BL/6J m 272.0 91.8   10 29.0 0.338 150.0, 411.0 -0.08
C57BLKS/J f 262.0 204.0   9 68.0 0.778 128.0, 797.0 -0.03
C57BLKS/J m 205.0 20.9   5 9.36 0.102 170.0, 225.0 -0.28
C57BR/cdJ f 314.0 82.8   10 26.2 0.264 219.0, 491.0 0.24
C57BR/cdJ m 245.0 33.2   10 10.5 0.135 180.0, 282.0 -0.16
C57L/J f 198.0 40.3   10 12.8 0.203 142.0, 283.0 -0.37
C57L/J m 203.0 43.0   10 13.6 0.212 140.0, 262.0 -0.29
C58/J f 532.0 161.0   5 71.9 0.302 334.0, 766.0 1.4
C58/J m 353.0 50.4   7 19.1 0.143 282.0, 427.0 0.17
CAST/EiJ f 409.0 143.0   9 47.6 0.349 271.0, 729.0 0.75
CAST/EiJ m 410.0 229.0   8 81.1 0.559 206.0, 762.0 0.34
CBA/J f 111.0 23.9   8 8.43 0.214 73.0, 142.0 -0.83
CBA/J m 166.0 21.2   8 7.51 0.128 142.0, 198.0 -0.4
CZECHII/EiJ f 131.0 44.4   11 13.4 0.34 42.0, 183.0 -0.72
CZECHII/EiJ m 135.0 55.3   9 18.4 0.41 93.0, 271.0 -0.49
DBA/1J f 105.0 19.9   7 7.53 0.19 64.0, 122.0 -0.86
DBA/1J m 141.0 13.5   8 4.76 0.0953 121.0, 166.0 -0.48
DBA/2J f 102.0 24.8   9 8.26 0.244 68.0, 145.0 -0.88
DBA/2J m 156.0 16.8   9 5.59 0.108 141.0, 193.0 -0.43
FVB/NJ f 225.0 20.6   8 7.29 0.0918 193.0, 255.0 -0.23
FVB/NJ m 281.0 55.5   5 24.8 0.197 205.0, 351.0 -0.05
I/LnJ f 228.0 36.5   5 16.3 0.16 188.0, 271.0 -0.21
JF1/MsJ f 219.0 51.5   10 16.3 0.235 180.0, 355.0 -0.26
JF1/MsJ m 399.0 264.0   7 99.7 0.662 169.0, 929.0 0.31
KK/HlJ f 269.0 70.7   7 26.7 0.263 215.0, 421.0 0.01
LP/J f 190.0 25.4   10 8.03 0.133 147.0, 227.0 -0.41
LP/J m 198.0 31.2   11 9.41 0.158 160.0, 266.0 -0.3
MA/MyJ f 417.0 56.2   10 17.8 0.135 351.0, 490.0 0.79
MA/MyJ m 301.0 27.1   10 8.58 0.0901 267.0, 347.0 0.01
MOLF/EiJ f 1235.0 188.0   6 76.9 0.153 926.0, 1483.0 5.12
MOLF/EiJ m 2134.0 392.0   4 196.0 0.184 1809.0, 2681.0 5.61
MSM/MsJ f 126.0 19.8   8 7.01 0.157 87.0, 155.0 -0.75
MSM/MsJ m 137.0 18.7   11 5.64 0.137 103.0, 164.0 -0.49
NOD/ShiLtJ f 411.0 196.0   7 74.1 0.477 291.0, 847.0 0.76
NOD/ShiLtJ m 467.0 410.0   6 167.0 0.877 202.0, 1280.0 0.52
NON/ShiLtJ f 299.0 50.3   10 15.9 0.168 228.0, 366.0 0.17
NON/ShiLtJ m 279.0 62.3   12 18.0 0.224 208.0, 369.0 -0.05
NZB/BlNJ f 359.0 45.3   11 13.6 0.126 291.0, 422.0 0.48
NZB/BlNJ m 331.0 46.2   9 15.4 0.139 250.0, 384.0 0.1
NZW/LacJ f 212.0 28.0   9 9.33 0.132 163.0, 254.0 -0.3
NZW/LacJ m 244.0 34.3   8 12.1 0.14 183.0, 302.0 -0.16
PERA/EiJ f 278.0 65.6   9 21.9 0.236 165.0, 385.0 0.05
PERA/EiJ m 269.0 28.8   8 10.2 0.107 238.0, 324.0 -0.09
PL/J f 258.0 63.5   10 20.1 0.246 183.0, 373.0 -0.05
PWK/PhJ m 164.0 29.4   8 10.4 0.18 107.0, 195.0 -0.41
RF/J f 214.0 36.7   7 13.9 0.172 165.0, 286.0 -0.28
RIIIS/J f 228.0 54.9   6 22.4 0.24 154.0, 294.0 -0.21
RIIIS/J m 156.0 22.5   8 7.94 0.144 126.0, 186.0 -0.43
SEA/GnJ f 145.0 30.0   9 10.0 0.207 110.0, 214.0 -0.65
SEA/GnJ m 193.0 14.8   7 5.59 0.0765 178.0, 214.0 -0.32
SJL/J f 135.0 20.2   9 6.72 0.149 112.0, 160.0 -0.7
SJL/J m 226.0 53.7   12 15.5 0.237 112.0, 310.0 -0.22
SM/J f 234.0 65.2   8 23.1 0.279 166.0, 337.0 -0.18
SM/J m 261.0 95.5   9 31.8 0.367 139.0, 450.0 -0.11
SPRET/EiJ f 254.0 25.8   4 12.9 0.102 222.0, 285.0 -0.07
SPRET/EiJ m 217.0 17.5   5 7.81 0.0804 198.0, 245.0 -0.24
SWR/J f 214.0 31.8   8 11.3 0.149 169.0, 272.0 -0.28
SWR/J m 213.0 28.5   7 10.8 0.134 183.0, 257.0 -0.26
WSB/EiJ f 282.0 90.8   8 32.1 0.322 173.0, 482.0 0.08
WSB/EiJ m 244.0 29.0   9 9.68 0.119 212.0, 296.0 -0.16


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 222.2 30.6893 282.4894 161.9106
129S1/SvImJ m 241.8889 32.3493 305.4395 178.3383
A/J f 556.7 30.6893 616.9894 496.4106
A/J m 509.25 34.3117 576.6556 441.8444
BALB/cByJ f 166.1818 29.2611 223.6655 108.6981
BALB/cByJ m 194.5 34.3117 261.9056 127.0944
BTBR T+ Itpr3tf/J f 178.0 34.3117 245.4056 110.5944
BTBR T+ Itpr3tf/J m 198.1429 36.6807 270.2025 126.0832
BUB/BnJ f 224.7 30.6893 284.9894 164.4106
BUB/BnJ m 157.8 43.4012 243.0621 72.5379
C3H/HeJ f 238.2 30.6893 298.4894 177.9106
C3H/HeJ m 216.625 34.3117 284.0306 149.2194
C57BL/10J f 144.1111 32.3493 207.6617 80.5605
C57BL/10J m 172.2 30.6893 232.4894 111.9106
C57BL/6J f 199.5 30.6893 259.7894 139.2106
C57BL/6J m 271.7 30.6893 331.9894 211.4106
C57BLKS/J f 262.2222 32.3493 325.7728 198.6716
C57BLKS/J m 204.8 43.4012 290.0621 119.5379
C57BR/cdJ f 313.6 30.6893 373.8894 253.3106
C57BR/cdJ m 244.9 30.6893 305.1894 184.6106
C57L/J f 198.4 30.6893 258.6894 138.1106
C57L/J m 202.9 30.6893 263.1894 142.6106
C58/J f 532.4 43.4012 617.6621 447.1379
C58/J m 353.2857 36.6807 425.3453 281.2261
CAST/EiJ f 409.3333 32.3493 472.8839 345.7827
CAST/EiJ m 410.25 34.3117 477.6556 342.8444
CBA/J f 111.25 34.3117 178.6556 43.8444
CBA/J m 166.375 34.3117 233.7806 98.9694
CZECHII/EiJ f 130.5455 29.2611 188.0291 73.0618
CZECHII/EiJ m 134.7778 32.3493 198.3284 71.2272
DBA/1J f 104.8571 36.6807 176.9168 32.7975
DBA/1J m 141.25 34.3117 208.6556 73.8444
DBA/2J f 101.5556 32.3493 165.1062 38.005
DBA/2J m 155.8889 32.3493 219.4395 92.3383
FVB/NJ f 224.75 34.3117 292.1556 157.3444
FVB/NJ m 281.2 43.4012 366.4621 195.9379
JF1/MsJ f 219.2 30.6893 279.4894 158.9106
JF1/MsJ m 398.7143 36.6807 470.7739 326.6547
LP/J f 190.5 30.6893 250.7894 130.2106
LP/J m 197.7273 29.2611 255.211 140.2436
MA/MyJ f 417.1 30.6893 477.3894 356.8106
MA/MyJ m 301.2 30.6893 361.4894 240.9106
MOLF/EiJ f 1234.8333 39.6197 1312.6666 1157.0001
MOLF/EiJ m 2133.75 48.524 2229.0759 2038.4241
MSM/MsJ f 126.0 34.3117 193.4056 58.5944
MSM/MsJ m 136.8182 29.2611 194.3019 79.3345
NOD/ShiLtJ f 411.1429 36.6807 483.2025 339.0832
NOD/ShiLtJ m 467.3333 39.6197 545.1666 389.5001
NON/ShiLtJ f 299.1 30.6893 359.3894 238.8106
NON/ShiLtJ m 278.6667 28.0153 333.7031 223.6302
NZB/BlNJ f 359.3636 29.2611 416.8473 301.88
NZB/BlNJ m 331.1111 32.3493 394.6617 267.5605
NZW/LacJ f 211.7778 32.3493 275.3284 148.2272
NZW/LacJ m 244.5 34.3117 311.9056 177.0944
PERA/EiJ f 277.7778 32.3493 341.3284 214.2272
PERA/EiJ m 269.25 34.3117 336.6556 201.8444
RIIIS/J f 228.5 39.6197 306.3333 150.6667
RIIIS/J m 156.0 34.3117 223.4056 88.5944
SEA/GnJ f 145.3333 32.3493 208.8839 81.7827
SEA/GnJ m 193.2857 36.6807 265.3453 121.2261
SJL/J f 135.2222 32.3493 198.7728 71.6716
SJL/J m 226.1667 28.0153 281.2031 171.1302
SM/J f 233.75 34.3117 301.1556 166.3444
SM/J m 260.5556 32.3493 324.1062 197.005
SPRET/EiJ f 254.0 48.524 349.3259 158.6741
SPRET/EiJ m 217.4 43.4012 302.6621 132.1379
SWR/J f 214.0 34.3117 281.4056 146.5944
SWR/J m 213.2857 36.6807 285.3453 141.2261
WSB/EiJ f 282.25 34.3117 349.6556 214.8444
WSB/EiJ m 244.3333 32.3493 307.8839 180.7827


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 232.0444 22.2952 275.8437 188.2452
A/J both 532.975 23.017 578.192 487.758
BALB/cByJ both 180.3409 22.5472 224.6351 136.0468
BTBR T+ Itpr3tf/J both 188.0714 25.1136 237.4073 138.7356
BUB/BnJ both 191.25 26.5777 243.4621 139.0379
C3H/HeJ both 227.4125 23.017 272.6295 182.1955
C57BL/10J both 158.1556 22.2952 201.9548 114.3563
C57BL/6J both 235.6 21.7006 278.231 192.969
C57BLKS/J both 233.5111 27.0654 286.6814 180.3409
C57BR/cdJ both 279.25 21.7006 321.881 236.619
C57L/J both 200.65 21.7006 243.281 158.019
C58/J both 442.8429 28.4127 498.66 387.0257
CAST/EiJ both 409.7917 23.5784 456.1117 363.4716
CBA/J both 138.8125 24.262 186.4755 91.1495
CZECHII/EiJ both 132.6616 21.8099 175.5074 89.8158
DBA/1J both 123.0536 25.1136 172.3894 73.7177
DBA/2J both 128.7222 22.8744 173.6593 83.7852
FVB/NJ both 252.975 27.6629 307.3191 198.6309
JF1/MsJ both 308.9571 23.9129 355.9343 261.98
LP/J both 194.1136 21.2017 235.7645 152.4627
MA/MyJ both 359.15 21.7006 401.781 316.519
MOLF/EiJ both 1684.2917 31.3221 1745.8243 1622.7591
MSM/MsJ both 131.4091 22.5472 175.7032 87.1149
NOD/ShiLtJ both 439.2381 26.9963 492.2725 386.2037
NON/ShiLtJ both 288.8833 20.7767 329.6994 248.0672
NZB/BlNJ both 345.2374 21.8099 388.0832 302.3916
NZW/LacJ both 228.1389 23.5784 274.459 181.8188
PERA/EiJ both 273.5139 23.5784 319.834 227.1938
RIIIS/J both 192.25 26.206 243.7319 140.7681
SEA/GnJ both 169.3095 24.4538 217.3493 121.2698
SJL/J both 180.6944 21.3971 222.7292 138.6597
SM/J both 247.1528 23.5784 293.4728 200.8327
SPRET/EiJ both 235.7 32.5509 299.6466 171.7534
SWR/J both 213.6429 25.1136 262.9787 164.307
WSB/EiJ both 263.2917 23.5784 309.6117 216.9716




  GWAS USING LINEAR MIXED MODELS