Project measure / variable:   Paigen2   nonHDL

ID, description, units MPD:9905   nonHDL   non-HDL cholesterol (plasma)   [mg/dL]  baseline  
high-fat diet study
Data set, strains Paigen2   inbred w/CC7   42 strains     sex: both     age: 7-9wks
Procedure lipid profile
Ontology mappings

  STRAIN COMPARISON PLOT
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Paigen2 - non-HDL cholesterol (plasma) baseline



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested40 strains41 strains
Mean of the strain means28.1   mg/dL 26.8   mg/dL
Median of the strain means25.4   mg/dL 25.6   mg/dL
SD of the strain means± 15.3 ± 13.2
Coefficient of variation (CV)0.543 0.493
Min–max range of strain means4.97   –   93.5   mg/dL 6.89   –   72.1   mg/dL
Mean sample size per strain10.2   mice 11.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 836.2715 836.2715 2.5086 0.1136
strain 38 102533.6343 2698.2535 8.0941 < 0.0001
sex:strain 38 27759.1146 730.503 2.1913 0.0001
Residuals 789 263021.156 333.3601


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 46.0 15.6   10 4.95 0.34 20.0, 67.0 1.17
129S1/SvImJ m 36.2 16.7   9 5.56 0.46 15.0, 68.0 0.72
A/J f 23.5 9.89   11 2.98 0.42 6.0, 44.0 -0.3
A/J m 20.4 16.0   23 3.35 0.787 -0.48
AKR/J f 29.4 10.1   14 2.7 0.343 16.0, 47.0 0.08
AKR/J m 23.2 12.1   9 4.04 0.522 2.0, 40.0 -0.27
BALB/cByJ f 23.9 23.3   12 6.73 0.975 -0.28
BALB/cByJ m 12.4 12.6   22 2.68 1.02 -1.09
BTBR T+ Itpr3tf/J f 22.4 12.0   8 4.25 0.536 5.1, 40.0 -0.37
BTBR T+ Itpr3tf/J m 16.9 9.6   7 3.63 0.568 1.6, 27.3 -0.75
BUB/BnJ f 15.1 10.4   11 3.15 0.693 1.0, 39.9 -0.85
BUB/BnJ m 21.4 14.4   5 6.46 0.675 -0.41
C3H/HeJ f 25.6 26.6   10 8.41 1.04 -0.16
C3H/HeJ m 23.6 29.0   25 5.81 1.23 -0.24
C57BL/10J f 29.2 9.84   10 3.11 0.337 15.0, 43.0 0.07
C57BL/10J m 34.1 21.8   15 5.63 0.639 0.56
C57BL/6J f 33.4 17.7   10 5.6 0.53 19.0, 63.0 0.35
C57BL/6J m 44.7 21.6   10 6.83 0.483 21.0, 83.0 1.36
C57BLKS/J f 29.8 23.2   10 7.34 0.779 11.0, 92.0 0.11
C57BR/cdJ f 21.4 4.95   10 1.57 0.231 11.9, 27.0 -0.44
C57BR/cdJ m 23.7 17.1   12 4.95 0.722 -0.23
C57L/J f 33.3 9.98   10 3.16 0.3 14.0, 48.0 0.34
C57L/J m 19.6 10.4   10 3.28 0.529 -0.54
C58/J f 27.4 8.34   5 3.73 0.305 15.3, 36.0 -0.05
C58/J m 31.4 40.6   11 12.2 1.3 0.35
CAST/EiJ f 28.0 12.1   9 4.03 0.432 12.0, 50.0 -0.01
CAST/EiJ m 31.9 5.93   10 1.88 0.186 22.0, 40.0 0.39
CBA/J f 16.8 10.6   8 3.76 0.635 3.0, 34.0 -0.74
CBA/J m 36.8 22.4   10 7.09 0.609 11.0, 87.0 0.76
CE/J m 25.9 8.3   5 3.71 0.32 19.4, 38.7 -0.06
CZECHII/EiJ f 16.6 7.96   18 1.88 0.481 -0.75
CZECHII/EiJ m 15.4 21.1   13 5.86 1.37 -0.86
DBA/1J f 15.7 23.5   9 7.82 1.49 -0.81
DBA/1J m 31.1 34.8   10 11.0 1.12 0.33
DBA/2J f 37.5 8.64   10 2.73 0.231 27.0, 55.0 0.62
DBA/2J m 53.0 22.3   10 7.06 0.421 18.0, 82.0 1.99
FVB/NJ f 50.2 23.6   11 7.12 0.471 12.0, 92.0 1.45
FVB/NJ m 26.1 7.69   10 2.43 0.295 12.0, 43.0 -0.05
I/LnJ f 13.4 6.87   10 2.17 0.512 2.0, 21.0 -0.96
I/LnJ m 12.6 9.43   10 2.98 0.748 -1.07
JF1/MsJ f 35.3 10.6   10 3.34 0.299 25.0, 55.0 0.47
JF1/MsJ m 25.6 15.9   14 4.24 0.619 -0.09
KK/HlJ f 93.5 54.6   5 24.4 0.584 51.0, 189.0 4.28
KK/HlJ m 72.1 62.7   3 36.2 0.87 2.0, 123.0 3.44
LP/J f 39.5 39.0   11 11.8 0.986 0.75
LP/J m 23.0 27.1   12 7.82 1.18 -0.28
MA/MyJ f 40.9 13.1   10 4.14 0.32 22.0, 63.0 0.84
MA/MyJ m 45.7 8.71   10 2.75 0.19 34.0, 60.0 1.44
MOLF/EiJ f 42.3 18.0   7 6.79 0.425 24.0, 78.0 0.93
MOLF/EiJ m 28.6 12.9   13 3.58 0.451 16.0, 56.0 0.14
MSM/MsJ f 25.2 14.6   8 5.16 0.578 -0.19
MSM/MsJ m 10.0 9.35   14 2.5 0.935 -1.27
NOD/ShiLtJ f 24.1 11.1   16 2.77 0.46 -0.26
NOD/ShiLtJ m 26.5 17.0   12 4.91 0.642 -0.02
NON/ShiLtJ f 15.9 8.14   10 2.58 0.513 -0.8
NON/ShiLtJ m 38.5 21.4   12 6.17 0.555 17.0, 96.2 0.89
NZB/BlNJ f 43.4 21.1   14 5.63 0.485 1.0
NZB/BlNJ m 19.2 12.9   10 4.07 0.67 -0.57
NZW/LacJ f 18.0 12.5   10 3.95 0.693 -0.66
NZW/LacJ m 42.0 27.5   8 9.74 0.656 1.15
PERA/EiJ f 6.56 11.8   9 3.93 1.8 -1.41
PERA/EiJ m 6.89 8.54   9 2.85 1.24 -1.5
PL/J f 38.9 18.5   11 5.59 0.476 21.0, 84.2 0.71
PL/J m 33.5 18.4   11 5.55 0.549 16.0, 84.0 0.51
PWK/PhJ m 14.3 10.8   16 2.71 0.761 -0.94
RF/J f 23.3 18.0   12 5.2 0.772 -0.31
RF/J m 30.5 28.2   13 7.81 0.922 0.28
RIIIS/J f 4.97 4.27   10 1.35 0.859 -1.52
RIIIS/J m 11.6 9.67   22 2.06 0.83 -1.15
SEA/GnJ f 20.6 11.3   10 3.57 0.547 -0.49
SEA/GnJ m 10.7 6.99   7 2.64 0.653 -1.22
SJL/J f 38.9 17.1   10 5.4 0.439 22.0, 76.0 0.71
SJL/J m 34.6 14.8   15 3.82 0.428 10.0, 62.0 0.59
SM/J f 15.0 2.42   9 0.807 0.161 11.8, 19.9 -0.86
SM/J m 18.9 20.4   16 5.1 1.08 -0.59
SPRET/EiJ f 25.6 15.3   11 4.62 0.598 -0.16
SPRET/EiJ m 15.9 15.1   13 4.18 0.946 -0.82
SWR/J f 25.2 17.8   12 5.15 0.707 -0.19
SWR/J m 37.8 16.4   12 4.73 0.434 11.0, 61.0 0.84
WSB/EiJ f 8.62 11.8   8 4.17 1.37 -1.28
WSB/EiJ m 10.6 14.0   11 4.23 1.32 -1.22


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 46.0 5.7737 57.3337 34.6663
129S1/SvImJ m 36.2222 6.0861 48.169 24.2755
A/J f 23.5455 5.505 34.3517 12.7392
A/J m 20.3913 3.8071 27.8645 12.9181
AKR/J f 29.4286 4.8797 39.0073 19.8498
AKR/J m 23.2222 6.0861 35.169 11.2755
BALB/cByJ f 23.9167 5.2707 34.2629 13.5705
BALB/cByJ m 12.3636 3.8927 20.0048 4.7225
BTBR T+ Itpr3tf/J f 22.4375 6.4552 35.109 9.766
BTBR T+ Itpr3tf/J m 16.9 6.9009 30.4464 3.3536
BUB/BnJ f 15.0636 5.505 25.8699 4.2574
BUB/BnJ m 21.4 8.1653 37.4283 5.3717
C3H/HeJ f 25.6 5.7737 36.9337 14.2663
C3H/HeJ m 23.6 3.6516 30.7681 16.4319
C57BL/10J f 29.2 5.7737 40.5337 17.8663
C57BL/10J m 34.1333 4.7142 43.3873 24.8794
C57BL/6J f 33.4 5.7737 44.7337 22.0663
C57BL/6J m 44.7 5.7737 56.0337 33.3663
C57BR/cdJ f 21.44 5.7737 32.7737 10.1063
C57BR/cdJ m 23.7317 5.2707 34.0779 13.3855
C57L/J f 33.3 5.7737 44.6337 21.9663
C57L/J m 19.6 5.7737 30.9337 8.2663
C58/J f 27.36 8.1653 43.3883 11.3317
C58/J m 31.3727 5.505 42.179 20.5665
CAST/EiJ f 28.0 6.0861 39.9468 16.0532
CAST/EiJ m 31.9 5.7737 43.2337 20.5663
CBA/J f 16.75 6.4552 29.4215 4.0785
CBA/J m 36.8 5.7737 48.1337 25.4663
CZECHII/EiJ f 16.5556 4.3035 25.0032 8.1079
CZECHII/EiJ m 15.3846 5.0639 25.3249 5.4443
DBA/1J f 15.7 6.0861 27.6468 3.7532
DBA/1J m 31.05 5.7737 42.3837 19.7163
DBA/2J f 37.5 5.7737 48.8337 26.1663
DBA/2J m 53.0 5.7737 64.3337 41.6663
FVB/NJ f 50.1818 5.505 60.9881 39.3756
FVB/NJ m 26.1 5.7737 37.4337 14.7663
I/LnJ f 13.4 5.7737 24.7337 2.0663
I/LnJ m 12.6 5.7737 23.9337 1.2663
JF1/MsJ f 35.3 5.7737 46.6337 23.9663
JF1/MsJ m 25.6357 4.8797 35.2144 16.057
KK/HlJ f 93.54 8.1653 109.5683 77.5117
KK/HlJ m 72.0667 10.5413 92.7591 51.3743
LP/J f 39.5273 5.505 50.3335 28.721
LP/J m 23.0 5.2707 33.3462 12.6538
MA/MyJ f 40.9 5.7737 52.2337 29.5663
MA/MyJ m 45.7 5.7737 57.0337 34.3663
MOLF/EiJ f 42.2857 6.9009 55.8321 28.7394
MOLF/EiJ m 28.6154 5.0639 38.5557 18.6751
MSM/MsJ f 25.25 6.4552 37.9215 12.5785
MSM/MsJ m 10.0 4.8797 19.5787 0.4213
NOD/ShiLtJ f 24.0625 4.5645 33.0226 15.1024
NOD/ShiLtJ m 26.5 5.2707 36.8462 16.1538
NON/ShiLtJ f 15.86 5.7737 27.1937 4.5263
NON/ShiLtJ m 38.525 5.2707 48.8712 28.1788
NZB/BlNJ f 43.4286 4.8797 53.0073 33.8498
NZB/BlNJ m 19.2 5.7737 30.5337 7.8663
NZW/LacJ f 18.0 5.7737 29.3337 6.6663
NZW/LacJ m 42.0 6.4552 54.6715 29.3285
PERA/EiJ f 6.5556 6.0861 18.5023 0.0
PERA/EiJ m 6.8889 6.0861 18.8357 0.0
PL/J f 38.9273 5.505 49.7335 28.121
PL/J m 33.5455 5.505 44.3517 22.7392
RF/J f 23.3333 5.2707 33.6795 12.9871
RF/J m 30.5385 5.0639 40.4788 20.5982
RIIIS/J f 4.97 5.7737 16.3037 0.0
RIIIS/J m 11.6409 3.8927 19.2821 3.9997
SEA/GnJ f 20.65 5.7737 31.9837 9.3163
SEA/GnJ m 10.7143 6.9009 24.2606 0.0
SJL/J f 38.9 5.7737 50.2337 27.5663
SJL/J m 34.6 4.7142 43.8539 25.3461
SM/J f 15.0444 6.0861 26.9912 3.0977
SM/J m 18.8875 4.5645 27.8476 9.9274
SPRET/EiJ f 25.6364 5.505 36.4426 14.8301
SPRET/EiJ m 15.9231 5.0639 25.8634 5.9828
SWR/J f 25.25 5.2707 35.5962 14.9038
SWR/J m 37.75 5.2707 48.0962 27.4038
WSB/EiJ f 8.625 6.4552 21.2965 0.0
WSB/EiJ m 10.6364 5.505 21.4426 0.0


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 41.1111 4.1945 49.3449 32.8774
A/J both 21.9684 3.3466 28.5377 15.3991
AKR/J both 26.3254 3.9004 33.9817 18.6691
BALB/cByJ both 18.1402 3.2762 24.5712 11.7091
BTBR T+ Itpr3tf/J both 19.6688 4.7247 28.9433 10.3942
BUB/BnJ both 18.2318 4.9239 27.8972 8.5664
C3H/HeJ both 24.6 3.4158 31.3051 17.8949
C57BL/10J both 31.6667 3.7269 38.9825 24.3508
C57BL/6J both 39.05 4.0826 47.0641 31.0359
C57BR/cdJ both 22.5858 3.9088 30.2588 14.9129
C57L/J both 26.45 4.0826 34.4641 18.4359
C58/J both 29.3664 4.9239 39.0318 19.701
CAST/EiJ both 29.95 4.1945 38.1837 21.7163
CBA/J both 26.775 4.3303 35.2753 18.2747
CZECHII/EiJ both 15.9701 3.3228 22.4926 9.4476
DBA/1J both 23.375 4.1945 31.6087 15.1413
DBA/2J both 45.25 4.0826 53.2641 37.2359
FVB/NJ both 38.1409 3.9888 45.9708 30.311
I/LnJ both 13.0 4.0826 21.0141 4.9859
JF1/MsJ both 30.4679 3.7798 37.8875 23.0482
KK/HlJ both 82.8033 6.6669 95.8904 69.7163
LP/J both 31.2636 3.8107 38.7439 23.7833
MA/MyJ both 43.3 4.0826 51.3141 35.2859
MOLF/EiJ both 35.4505 4.2798 43.8516 27.0495
MSM/MsJ both 17.625 4.046 25.5673 9.6827
NOD/ShiLtJ both 25.2813 3.4862 32.1246 18.4379
NON/ShiLtJ both 27.1925 3.9088 34.8655 19.5195
NZB/BlNJ both 31.3143 3.7798 38.7339 23.8946
NZW/LacJ both 30.0 4.3303 38.5003 21.4997
PERA/EiJ both 6.7222 4.3035 15.1699 0.0
PL/J both 36.2364 3.8927 43.8775 28.5952
RF/J both 26.9359 3.6546 34.1097 19.7621
RIIIS/J both 8.3055 3.4817 15.1399 1.471
SEA/GnJ both 15.6821 4.4989 24.5133 6.851
SJL/J both 36.75 3.7269 44.0659 29.4341
SM/J both 16.966 3.8038 24.4327 9.4992
SPRET/EiJ both 20.7797 3.7399 28.1211 13.4383
SWR/J both 31.5 3.7269 38.8159 24.1841
WSB/EiJ both 9.6307 4.2419 17.9575 1.3039




  GWAS USING LINEAR MIXED MODELS