Phenotype measure:   Neuner1   cfa_change_6mo

ID, description, units MPD:65972   cfa_change_6mo   change in percentage of time spent freezing from 1st post-shock to 4th post-shock (slope), day 1 contextual fear acquisition    6 mo
Data set, strains Neuner1   F1 AD-BXD   50 strains     sex: both     age: 23-57wks
Procedure fear conditioning test
Ontology mappings

  STRAIN COMPARISON PLOT
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Neuner1 - change in percentage of time spent freezing from 1st post-shock to 4th post-shock (slope), day 1 contextual fear acquisition 6 mo



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested50 strains27 strains
Mean of the strain means8.5304   None 7.4818   None
Median of the strain means7.6891   None 8.2767   None
SD of the strain means± 5.2155 ± 6.287
Coefficient of variation (CV)0.6114 0.8403
Min–max range of strain means1.0435   –   27.326   None -6.115   –   18.402   None
Mean sample size per strain3.7   mice 2.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 9.589 9.589 0.2176 0.6419
strain 13 1685.5404 129.657 2.9422 0.0012
sex:strain 13 566.5572 43.5813 0.989 0.4681
Residuals 95 4186.432 44.0677


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
(B6.5XFAD x B6)F1-ADtg f 3.1575 6.9304   2   4.9005 2.1949 -1.743, 8.058 -1.03
(B6.5XFAD x B6)F1-ADtg m 9.9871 3.3876   7 1.2804 0.3392 5.732, 16.285 0.4
(B6.5XFAD x B6)F1-Ntg f 6.247 5.4316   6 2.2174 0.8695 -1.135, 13.484 -0.44
(B6.5XFAD x B6)F1-Ntg m 15.432 7.8214   4 3.9107 0.5068 3.738, 20.0 1.26
(B6.5XFAD x BXD100)F1-ADtg f 6.447 4.7073   4 2.3536 0.7302 0.448, 11.952 -0.4
(B6.5XFAD x BXD100)F1-ADtg m 6.0005 2.9225   2   2.0665 0.487 3.934, 8.067 -0.24
(B6.5XFAD x BXD100)F1-Ntg f 10.068 2.4501   2   1.7325 0.2434 8.335, 11.8 0.29
(B6.5XFAD x BXD14)F1-ADtg f 4.046 8.3102   5 3.7164 2.0539 -8.478, 12.376 -0.86
(B6.5XFAD x BXD14)F1-Ntg f 19.863 3.2513   2   2.299 0.1637 17.564, 22.162 2.17
(B6.5XFAD x BXD16)F1-ADtg f 4.5175 3.6012   4 1.8006 0.7972 0.867, 9.4 -0.77
(B6.5XFAD x BXD22)F1-ADtg f 8.345 1.6754   3 0.96727 0.2008 6.71, 10.058 -0.04
(B6.5XFAD x BXD22)F1-Ntg f 15.462 0.0   1   0.0 0.0 15.462, 15.462 1.33
(B6.5XFAD x BXD2)F1-ADtg f 6.8123 4.6011   4 2.3005 0.6754 3.801, 13.534 -0.33
(B6.5XFAD x BXD2)F1-Ntg f 11.505 2.6946   5 1.205 0.2342 9.134, 15.957 0.57
(B6.5XFAD x BXD32)F1-ADtg f 6.484 6.4566   4 3.2283 0.9958 -1.531, 13.467 -0.39
(B6.5XFAD x BXD32)F1-ADtg m 1.271 2.3646   2   1.672 1.8604 -0.401, 2.943 -0.99
(B6.5XFAD x BXD32)F1-Ntg f 5.215 0.0   1   0.0 0.0 5.215, 5.215 -0.64
(B6.5XFAD x BXD32)F1-Ntg m 13.835 3.4422   2   2.434 0.2488 11.401, 16.269 1.01
(B6.5XFAD x BXD34)F1-ADtg f 7.9701 4.6189   9 1.5396 0.5795 3.6, 17.532 -0.11
(B6.5XFAD x BXD34)F1-Ntg f 12.213 8.9508   11 2.6988 0.7329 -0.668, 26.135 0.71
(B6.5XFAD x BXD42)F1-ADtg f 6.1047 6.4674   6 2.6403 1.0594 -0.74, 17.032 -0.47
(B6.5XFAD x BXD42)F1-Ntg f 2.6508 7.8199   4 3.91 2.9501 -7.465, 9.4 -1.13
(B6.5XFAD x BXD44)F1-ADtg f 8.1195 1.7727   2   1.2535 0.2183 6.866, 9.373 -0.08
(B6.5XFAD x BXD44)F1-ADtg m 3.9795 3.3397   2   2.3615 0.8392 1.618, 6.341 -0.56
(B6.5XFAD x BXD44)F1-Ntg f 13.134 8.6734   2   6.133 0.6604 7.001, 19.267 0.88
(B6.5XFAD x BXD44)F1-Ntg m 5.0 0.0   1   0.0 0.0 5.0, 5.0 -0.39
(B6.5XFAD x BXD51)F1-ADtg f 1.8103 7.1396   3 4.122 3.9438 -6.233, 7.398 -1.29
(B6.5XFAD x BXD51)F1-Ntg f 19.223 7.6591   3 4.422 0.3984 10.535, 25.0 2.05
(B6.5XFAD x BXD55)F1-ADtg f 6.333 5.5138   3 3.1834 0.8706 -0.42
(B6.5XFAD x BXD55)F1-Ntg f 8.9543 5.6584   4 2.8292 0.6319 1.199, 14.349 0.08
(B6.5XFAD x BXD56)F1-ADtg f 10.585 4.092   2   2.8935 0.3866 7.692, 13.479 0.39
(B6.5XFAD x BXD56)F1-Ntg f 8.811 6.3266   3 3.6527 0.718 2.416, 15.067 0.05
(B6.5XFAD x BXD60)F1-ADtg f 12.62 6.6284   2   4.687 0.5252 7.933, 17.307 0.78
(B6.5XFAD x BXD60)F1-ADtg m 9.454 5.2227   2   3.693 0.5524 5.761, 13.147 0.31
(B6.5XFAD x BXD60)F1-Ntg f 12.138 13.948   2   9.863 1.1492 2.275, 22.001 0.69
(B6.5XFAD x BXD61)F1-ADtg f 4.8885 7.6177   2   5.3865 1.5583 -0.498, 10.275 -0.7
(B6.5XFAD x BXD61)F1-ADtg m 12.654 5.4864   2   3.8795 0.4336 8.775, 16.534 0.82
(B6.5XFAD x BXD61)F1-Ntg f 11.199 0.0   1   0.0 0.0 11.199, 11.199 0.51
(B6.5XFAD x BXD61)F1-Ntg m 12.34 0.47942   2   0.339 0.0389 12.001, 12.679 0.77
(B6.5XFAD x BXD62)F1-ADtg f 8.6 0.0   1   0.0 0.0 8.6, 8.6 0.01
(B6.5XFAD x BXD62)F1-ADtg m 0.733 0.37477   2   0.265 0.5113 0.468, 0.998 -1.07
(B6.5XFAD x BXD62)F1-Ntg f 2.534 4.3374   2   3.067 1.7117 -0.533, 5.601 -1.15
(B6.5XFAD x BXD62)F1-Ntg m 0.733 0.0   1   0.0 0.0 0.733, 0.733 -1.07
(B6.5XFAD x BXD65)F1-ADtg f 12.334 8.3358   3 4.8127 0.6759 5.134, 21.466 0.73
(B6.5XFAD x BXD65)F1-ADtg m 16.71 7.5752   2   5.3565 0.4533 11.354, 22.067 1.47
(B6.5XFAD x BXD65)F1-Ntg f 27.326 0.0   1   0.0 0.0 27.326, 27.326 3.6
(B6.5XFAD x BXD65)F1-Ntg m 15.573 2.0964   4 1.0482 0.1346 12.962, 17.399 1.29
(B6.5XFAD x BXD66)F1-ADtg f 10.808 0.0   1   0.0 0.0 10.808, 10.808 0.44
(B6.5XFAD x BXD66)F1-ADtg m 8.2767 1.4166   4 0.70831 0.1712 6.168, 9.103 0.13
(B6.5XFAD x BXD66)F1-Ntg f 12.067 0.0   1   0.0 0.0 12.067, 12.067 0.68
(B6.5XFAD x BXD66)F1-Ntg m 8.733 0.0   1   0.0 0.0 8.733, 8.733 0.2
(B6.5XFAD x BXD68)F1-ADtg f 2.735 5.0274   6 2.0524 1.8382 -2.454, 11.267 -1.11
(B6.5XFAD x BXD68)F1-ADtg m 11.799 0.0   1   0.0 0.0 11.799, 11.799 0.69
(B6.5XFAD x BXD68)F1-Ntg f 14.798 4.9331   9 1.6444 0.3334 8.201, 25.0 1.2
(B6.5XFAD x BXD68)F1-Ntg m 9.0675 7.7308   2   5.4665 0.8526 3.601, 14.534 0.25
(B6.5XFAD x BXD69)F1-ADtg f 6.6745 0.01485   2   0.0105 0.0022 6.664, 6.685 -0.36
(B6.5XFAD x BXD69)F1-ADtg m 18.402 0.0   1   0.0 0.0 18.402, 18.402 1.74
(B6.5XFAD x BXD69)F1-Ntg f 13.887 0.0   1   0.0 0.0 13.887, 13.887 1.03
(B6.5XFAD x BXD75)F1-ADtg f 1.0435 2.4815   4 1.2408 2.3781 -1.8, 4.132 -1.44
(B6.5XFAD x BXD75)F1-ADtg m -4.4 1.509   2   1.067 -0.3429 -5.467, -3.333 -1.89
(B6.5XFAD x BXD75)F1-Ntg f 3.5523 8.838   3 5.1026 2.488 -5.342, 12.333 -0.95
(B6.5XFAD x BXD75)F1-Ntg m 0.065 0.0   1   0.0 0.0 0.065, 0.065 -1.18
(B6.5XFAD x BXD77)F1-ADtg f 1.9065 5.4384   2   3.8455 2.8525 -1.939, 5.752 -1.27
(B6.5XFAD x BXD77)F1-ADtg m -6.115 0.0   1   0.0 0.0 -6.115, -6.115 -2.16
(B6.5XFAD x BXD77)F1-Ntg f 4.2965 4.1231   2   2.9155 0.9597 1.381, 7.212 -0.81
(B6.5XFAD x BXD77)F1-Ntg m 4.1655 2.8758   2   2.0335 0.6904 2.132, 6.199 -0.53
(B6.5XFAD x BXD81)F1-ADtg f 3.0307 5.5018   6 2.2461 1.8154 -4.4, 10.467 -1.05
(B6.5XFAD x BXD81)F1-Ntg f 7.4893 13.07   3 7.5461 1.7452 -5.399, 20.734 -0.2
(B6.5XFAD x BXD87)F1-ADtg f 7.889 5.5126   3 3.1827 0.6988 2.599, 13.6 -0.12
(B6.5XFAD x BXD87)F1-ADtg m 7.532 0.0   1   0.0 0.0 7.532, 7.532 0.01
(B6.5XFAD x BXD87)F1-Ntg f 6.282 7.0443   3 4.0671 1.1214 1.78, 14.4 -0.43
(B6.5XFAD x BXD87)F1-Ntg m 3.4113 14.13   3 8.1579 4.1421 -8.7, 18.935 -0.65
(B6.5XFAD x BXD99)F1-ADtg f 3.753 5.2545   3 3.0337 1.4001 -1.085, 9.343 -0.92
(B6.5XFAD x D2)F1-ADtg f 6.9145 6.7414   16 1.6854 0.975 -5.933, 20.817 -0.31
(B6.5XFAD x D2)F1-ADtg m 6.6144 6.843   13 1.8979 1.0346 -8.101, 15.025 -0.14
(B6.5XFAD x D2)F1-Ntg f 13.676 8.6308   11 2.6023 0.6311 1.401, 29.201 0.99
(B6.5XFAD x D2)F1-Ntg m 10.755 7.3222   8 2.5888 0.6808 -1.601, 21.001 0.52


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
(B6.5XFAD x B6)F1-ADtg f 3.1575 4.694 12.4763 -6.1613
(B6.5XFAD x B6)F1-ADtg m 9.9871 2.5091 14.9683 5.006
(B6.5XFAD x B6)F1-Ntg f 6.247 2.7101 11.6272 0.8668
(B6.5XFAD x B6)F1-Ntg m 15.4322 3.3192 22.0216 8.8429
(B6.5XFAD x BXD100)F1-ADtg f 6.447 3.3192 13.0364 -0.1424
(B6.5XFAD x BXD100)F1-ADtg m 6.0005 4.694 15.3193 -3.3183
(B6.5XFAD x BXD32)F1-ADtg f 6.484 3.3192 13.0734 -0.1054
(B6.5XFAD x BXD32)F1-ADtg m 1.271 4.694 10.5898 -8.0478
(B6.5XFAD x BXD44)F1-ADtg f 8.1195 4.694 17.4383 -1.1993
(B6.5XFAD x BXD44)F1-ADtg m 3.9795 4.694 13.2983 -5.3393
(B6.5XFAD x BXD60)F1-ADtg f 12.62 4.694 21.9388 3.3012
(B6.5XFAD x BXD60)F1-ADtg m 9.454 4.694 18.7728 0.1352
(B6.5XFAD x BXD61)F1-ADtg f 4.8885 4.694 14.2073 -4.4303
(B6.5XFAD x BXD61)F1-ADtg m 12.6545 4.694 21.9733 3.3357
(B6.5XFAD x BXD65)F1-ADtg f 12.3337 3.8327 19.9424 4.7249
(B6.5XFAD x BXD65)F1-ADtg m 16.7105 4.694 26.0293 7.3917
(B6.5XFAD x BXD68)F1-Ntg f 14.7978 2.2128 19.1907 10.4048
(B6.5XFAD x BXD68)F1-Ntg m 9.0675 4.694 18.3863 -0.2513
(B6.5XFAD x BXD75)F1-ADtg f 1.0435 3.3192 7.6329 -5.5459
(B6.5XFAD x BXD75)F1-ADtg m -4.4 4.694 4.9188 -13.7188
(B6.5XFAD x BXD77)F1-Ntg f 4.2965 4.694 13.6153 -5.0223
(B6.5XFAD x BXD77)F1-Ntg m 4.1655 4.694 13.4843 -5.1533
(B6.5XFAD x BXD87)F1-Ntg f 6.282 3.8327 13.8908 -1.3268
(B6.5XFAD x BXD87)F1-Ntg m 3.4113 3.8327 11.0201 -4.1974
(B6.5XFAD x D2)F1-ADtg f 6.9145 1.6596 10.2092 3.6198
(B6.5XFAD x D2)F1-ADtg m 6.6144 1.8411 10.2695 2.9592
(B6.5XFAD x D2)F1-Ntg f 13.6762 2.0015 17.6497 9.7026
(B6.5XFAD x D2)F1-Ntg m 10.7545 2.347 15.4139 6.0951


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
(B6.5XFAD x B6)F1-ADtg both 6.5723 2.6613 11.8556 1.2891
(B6.5XFAD x B6)F1-Ntg both 10.8396 2.1425 15.0931 6.5862
(B6.5XFAD x BXD100)F1-ADtg both 6.2237 2.8745 11.9303 0.5172
(B6.5XFAD x BXD32)F1-ADtg both 3.8775 2.8745 9.5841 -1.8291
(B6.5XFAD x BXD44)F1-ADtg both 6.0495 3.3192 12.6389 -0.5399
(B6.5XFAD x BXD60)F1-ADtg both 11.037 3.3192 17.6264 4.4476
(B6.5XFAD x BXD61)F1-ADtg both 8.7715 3.3192 15.3609 2.1821
(B6.5XFAD x BXD65)F1-ADtg both 14.5221 3.03 20.5374 8.5068
(B6.5XFAD x BXD68)F1-Ntg both 11.9326 2.5947 17.0838 6.7815
(B6.5XFAD x BXD75)F1-ADtg both -1.6783 2.8745 4.0283 -7.3848
(B6.5XFAD x BXD77)F1-Ntg both 4.231 3.3192 10.8204 -2.3584
(B6.5XFAD x BXD87)F1-Ntg both 4.8467 2.7101 10.2269 -0.5336
(B6.5XFAD x D2)F1-ADtg both 6.7644 1.2394 9.2249 4.304
(B6.5XFAD x D2)F1-Ntg both 12.2153 1.5423 15.2772 9.1535




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA