Phenotype measure:   Neuner1   amyloid_14mo

ID, description, units MPD:65910   amyloid_14mo   temporal cortex amyloid level (ng/mg total protein)   [ng/mg]  14 mo
Data set, strains Neuner1   F1 AD-BXD   21 strains     sex: both     age: 23-57wks
Procedure biomarker quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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Neuner1 - temporal cortex amyloid level (ng/mg total protein) 14 mo



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested20 strains17 strains
Mean of the strain means448.4   ng/mg 522.6   ng/mg
Median of the strain means402.5   ng/mg 453.1   ng/mg
SD of the strain means± 273.5 ± 249.2
Coefficient of variation (CV)0.61 0.4769
Min–max range of strain means118.0   –   1117.0   ng/mg 86.62   –   943.4   ng/mg
Mean sample size per strain2.1   mice 2.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 149877.1382 149877.1382 2.029 0.1632
strain 12 739188.0833 61599.0069 0.8339 0.6163
sex:strain 12 2210016.6314 184168.0526 2.4932 0.0176
Residuals 35 2585363.2034 73867.5201


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
(B6.5XFAD x B6)F1-ADtg f 463.4 0.0   1   0.0 0.0 463.375, 463.375 0.05
(B6.5XFAD x B6)F1-ADtg m 562.2 228.4   4 114.2 0.4063 330.290625, 875.75 0.16
(B6.5XFAD x BXD100)F1-ADtg f 919.5 22.097   2   15.625 0.024 903.875, 935.125 1.72
(B6.5XFAD x BXD100)F1-ADtg m 443.9 190.6   2   134.8 0.4293 309.125, 578.625 -0.32
(B6.5XFAD x BXD16)F1-ADtg f 440.6 168.4   2   119.1 0.3822 321.5, 559.625 -0.03
(B6.5XFAD x BXD22)F1-ADtg f 594.2 236.0   2   166.9 0.3971 427.375, 761.125 0.53
(B6.5XFAD x BXD32)F1-ADtg f 141.1 0.0   1   0.0 0.0 141.125, 141.125 -1.12
(B6.5XFAD x BXD32)F1-ADtg m 86.62 17.607   2   12.45 0.2033 74.175, 99.075 -1.75
(B6.5XFAD x BXD44)F1-ADtg f 689.1 497.1   5 222.3 0.7215 181.5, 1195.5 0.88
(B6.5XFAD x BXD44)F1-ADtg m 238.4 18.805   2   13.297 0.0789 225.125, 251.71875 -1.14
(B6.5XFAD x BXD51)F1-ADtg f 627.6 135.3   2   95.64 0.2155 531.975, 723.25 0.65
(B6.5XFAD x BXD55)F1-ADtg f 621.2 14.938   2   10.562 0.024 610.625, 631.75 0.63
(B6.5XFAD x BXD56)F1-ADtg m 192.7 41.631   2   29.438 0.2161 163.25, 222.125 -1.32
(B6.5XFAD x BXD60)F1-ADtg f 282.4 11.932   2   8.4375 0.0422 274.0, 290.875 -0.61
(B6.5XFAD x BXD60)F1-ADtg m 453.1 2.6958   2   1.9062 0.0059 451.1875, 455.0 -0.28
(B6.5XFAD x BXD61)F1-ADtg f 175.1 10.872   2   7.6875 0.0621 167.375, 182.75 -1.0
(B6.5XFAD x BXD61)F1-ADtg m 344.6 6.3868   2   4.5161 0.0185 340.0833333, 349.115625 -0.71
(B6.5XFAD x BXD62)F1-ADtg f 242.8 15.114   2   10.687 0.0622 232.125, 253.5 -0.75
(B6.5XFAD x BXD62)F1-ADtg m 912.9 31.378   2   22.188 0.0344 890.75, 935.125 1.57
(B6.5XFAD x BXD65)F1-ADtg f 183.0 19.622   2   13.875 0.1072 169.125, 196.875 -0.97
(B6.5XFAD x BXD65)F1-ADtg m 687.9 141.5   2   100.1 0.2057 587.875, 788.0 0.66
(B6.5XFAD x BXD66)F1-ADtg f 514.9 662.5   3 382.5 1.2867 44.30208333, 1272.5 0.24
(B6.5XFAD x BXD66)F1-ADtg m 393.9 50.56   2   35.75 0.1284 358.125, 429.625 -0.52
(B6.5XFAD x BXD68)F1-ADtg f 118.0 9.705   2   6.8625 0.0822 111.1375, 124.8625 -1.21
(B6.5XFAD x BXD68)F1-ADtg m 472.2 37.477   2   26.5 0.0794 445.75, 498.75 -0.2
(B6.5XFAD x BXD69)F1-ADtg f 364.4 48.147   2   34.045 0.1321 330.375, 398.4652778 -0.31
(B6.5XFAD x BXD69)F1-ADtg m 432.6 115.3   2   81.56 0.2667 351.0, 514.125 -0.36
(B6.5XFAD x BXD70)F1-ADtg f 1117.0 0.0   1   0.0 0.0 1117.25, 1117.25 2.44
(B6.5XFAD x BXD70)F1-ADtg m 943.4 22.362   2   15.812 0.0237 927.625, 959.25 1.69
(B6.5XFAD x BXD75)F1-ADtg f 219.3 20.329   2   14.375 0.0927 204.88, 233.63 -0.84
(B6.5XFAD x BXD75)F1-ADtg m 777.1 128.4   2   90.81 0.1653 686.25, 867.875 1.02
(B6.5XFAD x BXD77)F1-ADtg f 226.3 49.409   2   34.938 0.2183 191.375, 261.25 -0.81
(B6.5XFAD x BXD77)F1-ADtg m 798.3 45.343   2   32.062 0.0568 766.25, 830.375 1.11
(B6.5XFAD x BXD87)F1-ADtg f 326.5 100.6   2   71.11 0.308 255.375, 397.5902778 -0.45
(B6.5XFAD x BXD87)F1-ADtg m 713.9 38.095   2   26.938 0.0534 687.0, 740.875 0.77
(B6.5XFAD x D2)F1-ADtg f 702.4 403.6   4 201.8 0.5745 310.5392857, 1247.875 0.93
(B6.5XFAD x D2)F1-ADtg m 430.1 172.2   5 77.01 0.4003 198.453125, 603.125 -0.37


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
(B6.5XFAD x BXD100)F1-ADtg f 919.5 192.1816 1309.6494 529.3506
(B6.5XFAD x BXD100)F1-ADtg m 443.875 192.1816 834.0244 53.7256
(B6.5XFAD x BXD44)F1-ADtg f 689.0667 121.5463 935.8188 442.3146
(B6.5XFAD x BXD44)F1-ADtg m 238.4219 192.1816 628.5712 -151.7275
(B6.5XFAD x BXD60)F1-ADtg f 282.4375 192.1816 672.5869 -107.7119
(B6.5XFAD x BXD60)F1-ADtg m 453.0937 192.1816 843.2431 62.9444
(B6.5XFAD x BXD61)F1-ADtg f 175.0625 192.1816 565.2119 -215.0869
(B6.5XFAD x BXD61)F1-ADtg m 344.5995 192.1816 734.7488 -45.5499
(B6.5XFAD x BXD62)F1-ADtg f 242.8125 192.1816 632.9619 -147.3369
(B6.5XFAD x BXD62)F1-ADtg m 912.9375 192.1816 1303.0869 522.7881
(B6.5XFAD x BXD65)F1-ADtg f 183.0 192.1816 573.1494 -207.1494
(B6.5XFAD x BXD65)F1-ADtg m 687.9375 192.1816 1078.0869 297.7881
(B6.5XFAD x BXD66)F1-ADtg f 514.8792 156.9156 833.4348 196.3236
(B6.5XFAD x BXD66)F1-ADtg m 393.875 192.1816 784.0244 3.7256
(B6.5XFAD x BXD68)F1-ADtg f 118.0 192.1816 508.1494 -272.1494
(B6.5XFAD x BXD68)F1-ADtg m 472.25 192.1816 862.3994 82.1006
(B6.5XFAD x BXD69)F1-ADtg f 364.4201 192.1816 754.5695 -25.7292
(B6.5XFAD x BXD69)F1-ADtg m 432.5625 192.1816 822.7119 42.4131
(B6.5XFAD x BXD75)F1-ADtg f 219.255 192.1816 609.4044 -170.8944
(B6.5XFAD x BXD75)F1-ADtg m 777.0625 192.1816 1167.2119 386.9131
(B6.5XFAD x BXD77)F1-ADtg f 226.3125 192.1816 616.4619 -163.8369
(B6.5XFAD x BXD77)F1-ADtg m 798.3125 192.1816 1188.4619 408.1631
(B6.5XFAD x BXD87)F1-ADtg f 326.4826 192.1816 716.632 -63.6667
(B6.5XFAD x BXD87)F1-ADtg m 713.9375 192.1816 1104.0869 323.7881
(B6.5XFAD x D2)F1-ADtg f 702.4478 135.8929 978.3251 426.5706
(B6.5XFAD x D2)F1-ADtg m 430.1131 121.5463 676.8652 183.361


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
(B6.5XFAD x BXD100)F1-ADtg both 681.6875 135.8929 957.5648 405.8102
(B6.5XFAD x BXD44)F1-ADtg both 463.7443 113.6962 694.5597 232.9288
(B6.5XFAD x BXD60)F1-ADtg both 367.7656 135.8929 643.6429 91.8884
(B6.5XFAD x BXD61)F1-ADtg both 259.831 135.8929 535.7082 -16.0463
(B6.5XFAD x BXD62)F1-ADtg both 577.875 135.8929 853.7523 301.9977
(B6.5XFAD x BXD65)F1-ADtg both 435.4687 135.8929 711.346 159.5915
(B6.5XFAD x BXD66)F1-ADtg both 454.3771 124.0527 706.2174 202.5368
(B6.5XFAD x BXD68)F1-ADtg both 295.125 135.8929 571.0023 19.2477
(B6.5XFAD x BXD69)F1-ADtg both 398.4913 135.8929 674.3686 122.6141
(B6.5XFAD x BXD75)F1-ADtg both 498.1587 135.8929 774.036 222.2815
(B6.5XFAD x BXD77)F1-ADtg both 512.3125 135.8929 788.1898 236.4352
(B6.5XFAD x BXD87)F1-ADtg both 520.2101 135.8929 796.0873 244.3328
(B6.5XFAD x D2)F1-ADtg both 566.2805 91.1597 751.3446 381.2164




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA