Phenotype measure:   Neuner1   amyloid_6mo

ID, description, units MPD:65909   amyloid_6mo   temporal cortex amyloid level (ng/mg total protein)   [ng/mg]  6 mo
Data set, strains Neuner1   F1 AD-BXD   22 strains     sex: both     age: 23-57wks
Procedure biomarker quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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Neuner1 - temporal cortex amyloid level (ng/mg total protein) 6 mo



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested22 strains14 strains
Mean of the strain means107.5   ng/mg 61.98   ng/mg
Median of the strain means85.28   ng/mg 58.03   ng/mg
SD of the strain means± 66.2 ± 38.755
Coefficient of variation (CV)0.6159 0.6253
Min–max range of strain means41.438   –   282.4   ng/mg 4.7969   –   142.8   ng/mg
Mean sample size per strain2.1   mice 1.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 2233.245 2233.245 2.9646 0.1033
strain 6 44145.9391 7357.6565 9.767 0.0001
sex:strain 6 13742.4394 2290.4066 3.0404 0.033
Residuals 17 12806.3834 753.3167


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
(B6.5XFAD x B6)F1-ADtg f 41.438 6.2678   2   4.432 0.1513 37.00625, 45.8703125 -1.0
(B6.5XFAD x B6)F1-ADtg m 5.4323 3.3627   3 1.9414 0.619 2.015, 8.7375 -1.46
(B6.5XFAD x BXD100)F1-ADtg f 110.0 10.439   2   7.3813 0.0949 102.6, 117.3625 0.04
(B6.5XFAD x BXD100)F1-ADtg m 45.723 8.8941   2   6.2891 0.1945 39.434375, 52.0125 -0.42
(B6.5XFAD x BXD14)F1-ADtg f 72.88 31.442   2   22.233 0.4314 50.646875, 95.1125 -0.52
(B6.5XFAD x BXD16)F1-ADtg f 81.14 31.312   2   22.141 0.3859 59.0, 103.28125 -0.4
(B6.5XFAD x BXD22)F1-ADtg f 192.9 64.79   2   45.812 0.3359 147.0625, 238.6875 1.29
(B6.5XFAD x BXD32)F1-ADtg f 89.42 32.541   3 18.788 0.3639 67.0375, 126.75 -0.27
(B6.5XFAD x BXD32)F1-ADtg m 37.325 0.0   1   0.0 0.0 37.325, 37.325 -0.64
(B6.5XFAD x BXD44)F1-ADtg f 52.04 2.5809   2   1.825 0.0496 50.2125, 53.8625 -0.84
(B6.5XFAD x BXD44)F1-ADtg m 57.39 38.546   2   27.256 0.6716 30.1375, 84.65 -0.12
(B6.5XFAD x BXD51)F1-ADtg f 75.36 35.859   2   25.356 0.4759 50.0, 100.7125 -0.49
(B6.5XFAD x BXD55)F1-ADtg f 100.7 1.3347   2   0.94375 0.0133 99.7125, 101.6 -0.1
(B6.5XFAD x BXD56)F1-ADtg f 196.4 3.6239   2   2.5625 0.0185 193.8125, 198.9375 1.34
(B6.5XFAD x BXD60)F1-ADtg f 75.98 40.827   2   28.869 0.5373 47.1125, 104.85 -0.48
(B6.5XFAD x BXD60)F1-ADtg m 142.8 34.516   2   24.406 0.2416 118.4375, 167.25 2.09
(B6.5XFAD x BXD61)F1-ADtg f 54.26 3.0406   2   2.15 0.056 52.1125, 56.4125 -0.8
(B6.5XFAD x BXD61)F1-ADtg m 63.24 3.5444   2   2.5062 0.056 60.7375, 65.75 0.03
(B6.5XFAD x BXD62)F1-ADtg f 55.25 0.0   1   0.0 0.0 55.25, 55.25 -0.79
(B6.5XFAD x BXD62)F1-ADtg m 58.67 17.103   2   12.094 0.2915 46.575, 70.7625 -0.09
(B6.5XFAD x BXD65)F1-ADtg f 282.4 0.0   1   0.0 0.0 282.4375, 282.4375 2.64
(B6.5XFAD x BXD65)F1-ADtg m 103.9 11.623   2   8.2188 0.1119 95.6375, 112.075 1.08
(B6.5XFAD x BXD66)F1-ADtg f 89.94 0.0   1   0.0 0.0 89.9375, 89.9375 -0.27
(B6.5XFAD x BXD66)F1-ADtg m 87.96 21.942   3 12.668 0.2495 64.0125, 107.1 0.67
(B6.5XFAD x BXD68)F1-ADtg f 63.12 21.397   3 12.354 0.339 41.3125, 84.08125 -0.67
(B6.5XFAD x BXD68)F1-ADtg m 37.362 0.0   1   0.0 0.0 37.3625, 37.3625 -0.64
(B6.5XFAD x BXD69)F1-ADtg f 108.8 1.5424   2   1.0906 0.0142 107.74375, 109.925 0.02
(B6.5XFAD x BXD75)F1-ADtg f 163.1 79.35   2   56.11 0.4865 106.975, 219.1875 0.84
(B6.5XFAD x BXD75)F1-ADtg m 98.78 11.747   2   8.3063 0.1189 90.475, 107.0875 0.95
(B6.5XFAD x BXD77)F1-ADtg f 241.1 33.676   2   23.812 0.1397 217.3125, 264.9375 2.02
(B6.5XFAD x BXD77)F1-ADtg m 86.91 0.0   1   0.0 0.0 86.9125, 86.9125 0.64
(B6.5XFAD x BXD81)F1-ADtg f 108.2 70.13   2   49.587 0.6484 58.575, 157.75 0.01
(B6.5XFAD x BXD87)F1-ADtg f 66.33 53.16   3 30.69 0.8014 5.196666667, 101.65 -0.62
(B6.5XFAD x BXD87)F1-ADtg m 37.362 0.0   1   0.0 0.0 37.3625, 37.3625 -0.64
(B6.5XFAD x D2)F1-ADtg f 44.042 24.147   4 12.074 0.5483 21.0, 78.0625 -0.96
(B6.5XFAD x D2)F1-ADtg m 4.7969 0.95194   2   0.67312 0.1985 4.12375, 5.47 -1.48


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
(B6.5XFAD x B6)F1-ADtg f 41.4383 19.4077 82.3849 0.4916
(B6.5XFAD x B6)F1-ADtg m 5.4323 15.8463 38.8651 -28.0005
(B6.5XFAD x BXD100)F1-ADtg f 109.9812 19.4077 150.9279 69.0346
(B6.5XFAD x BXD100)F1-ADtg m 45.7234 19.4077 86.6701 4.7768
(B6.5XFAD x BXD44)F1-ADtg f 52.0375 19.4077 92.9841 11.0909
(B6.5XFAD x BXD44)F1-ADtg m 57.3937 19.4077 98.3404 16.4471
(B6.5XFAD x BXD60)F1-ADtg f 75.9812 19.4077 116.9279 35.0346
(B6.5XFAD x BXD60)F1-ADtg m 142.8438 19.4077 183.7904 101.8971
(B6.5XFAD x BXD61)F1-ADtg f 54.2625 19.4077 95.2091 13.3159
(B6.5XFAD x BXD61)F1-ADtg m 63.2437 19.4077 104.1904 22.2971
(B6.5XFAD x BXD75)F1-ADtg f 163.0813 19.4077 204.0279 122.1346
(B6.5XFAD x BXD75)F1-ADtg m 98.7813 19.4077 139.7279 57.8346
(B6.5XFAD x D2)F1-ADtg f 44.0422 13.7233 72.9958 15.0885
(B6.5XFAD x D2)F1-ADtg m 4.7969 19.4077 45.7435 -36.1498


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
(B6.5XFAD x B6)F1-ADtg both 23.4353 12.5276 49.8662 -2.9957
(B6.5XFAD x BXD100)F1-ADtg both 77.8523 13.7233 106.806 48.8987
(B6.5XFAD x BXD44)F1-ADtg both 54.7156 13.7233 83.6693 25.762
(B6.5XFAD x BXD60)F1-ADtg both 109.4125 13.7233 138.3661 80.4589
(B6.5XFAD x BXD61)F1-ADtg both 58.7531 13.7233 87.7068 29.7995
(B6.5XFAD x BXD75)F1-ADtg both 130.9313 13.7233 159.8849 101.9776
(B6.5XFAD x D2)F1-ADtg both 24.4195 11.8847 49.4941 -0.6551




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA