Project measure / variable:   GMC20   aDNA_21

ID, description, units MPD:56917   aDNA_21   anti-DNA autoantibodies (plasma)    at age 20-21wks  
Data set, strains GMC20   inbred w/CC8   8 strains     sex: both     age: 20-21wks
Procedure autoantibody quantification
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  STRAIN COMPARISON PLOT
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GMC20 - anti-DNA autoantibodies (plasma) at age 20-21wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means0.552   None 0.556   None
Median of the strain means0.497   None 0.464   None
SD of the strain means± 0.275 ± 0.361
Coefficient of variation (CV)0.498 0.650
Min–max range of strain means0.224   –   0.969   None 0.236   –   1.36   None
Mean sample size per strain8.9   mice 10.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.0005 0.0005 0.0146 0.9041
strain 7 12.0783 1.7255 46.4597 < 0.0001
sex:strain 7 0.8442 0.1206 3.2472 0.0032
Residuals 141 5.2366 0.0371


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.655 0.375   10 0.119 0.573 0.438, 1.7 0.38
129S1/SvImJ m 0.54 0.158   12 0.0456 0.292 0.333, 0.789 -0.04
A/J f 0.47 0.116   10 0.0368 0.248 0.336, 0.739 -0.3
A/J m 0.405 0.106   12 0.0307 0.263 0.295, 0.646 -0.42
C57BL/6J f 0.422 0.1   10 0.0318 0.238 0.301, 0.631 -0.47
C57BL/6J m 0.367 0.0685   12 0.0198 0.187 0.3, 0.547 -0.52
CAST/EiJ f 0.249 0.0732   8 0.0259 0.294 0.149, 0.353 -1.1
CAST/EiJ m 0.284 0.0786   9 0.0262 0.277 0.182, 0.402 -0.75
NOD/ShiLtJ f 0.9 0.316   7 0.119 0.351 0.602, 1.54 1.27
NOD/ShiLtJ m 0.733 0.174   9 0.0581 0.238 0.499, 0.981 0.49
NZO/HlLtJ f 0.969 0.0991   7 0.0374 0.102 0.836, 1.13 1.52
NZO/HlLtJ m 1.36 0.262   9 0.0873 0.192 0.964, 1.67 2.23
PWK/PhJ f 0.525 0.356   9 0.119 0.678 0.297, 1.38 -0.1
PWK/PhJ m 0.523 0.26   11 0.0784 0.498 0.286, 1.08 -0.09
WSB/EiJ f 0.224 0.0331   10 0.0105 0.147 0.165, 0.264 -1.19
WSB/EiJ m 0.236 0.0807   12 0.0233 0.342 0.162, 0.447 -0.89


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.6549 0.0609 0.7754 0.5344
129S1/SvImJ m 0.5397 0.0556 0.6497 0.4298
A/J f 0.47 0.0609 0.5905 0.3495
A/J m 0.405 0.0556 0.515 0.295
C57BL/6J f 0.4222 0.0609 0.5427 0.3017
C57BL/6J m 0.3667 0.0556 0.4766 0.2567
CAST/EiJ f 0.2486 0.0681 0.3833 0.1139
CAST/EiJ m 0.2841 0.0642 0.4111 0.1571
NOD/ShiLtJ f 0.9 0.0728 1.044 0.756
NOD/ShiLtJ m 0.7333 0.0642 0.8603 0.6063
NZO/HlLtJ f 0.969 0.0728 1.113 0.825
NZO/HlLtJ m 1.365 0.0642 1.492 1.238
PWK/PhJ f 0.5249 0.0642 0.6519 0.3979
PWK/PhJ m 0.5225 0.0581 0.6374 0.4076
WSB/EiJ f 0.2243 0.0609 0.3448 0.1038
WSB/EiJ m 0.2357 0.0556 0.3457 0.1258


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.5973 0.0413 0.6789 0.5158
A/J both 0.4375 0.0413 0.5191 0.3559
C57BL/6J both 0.3944 0.0413 0.476 0.3129
CAST/EiJ both 0.2664 0.0468 0.3589 0.1738
NOD/ShiLtJ both 0.8167 0.0486 0.9127 0.7207
NZO/HlLtJ both 1.167 0.0486 1.263 1.071
PWK/PhJ both 0.5237 0.0433 0.6093 0.4381
WSB/EiJ both 0.23 0.0413 0.3116 0.1485




  GWAS USING LINEAR MIXED MODELS