Project measure / variable:   GMC20   aDNA_17

ID, description, units MPD:56916   aDNA_17   anti-DNA autoantibodies (plasma)    at age 16-17wks  
Data set, strains GMC20   inbred w/CC8   7 strains     sex: both     age: 16-17wks
Procedure autoantibody quantification
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  STRAIN COMPARISON PLOT
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GMC20 - anti-DNA autoantibodies (plasma) at age 16-17wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested6 strains7 strains
Mean of the strain means0.231   None 0.200   None
Median of the strain means0.188   None 0.170   None
SD of the strain means± 0.0973 ± 0.0846
Coefficient of variation (CV)0.421 0.423
Min–max range of strain means0.138   –   0.383   None 0.140   –   0.376   None
Mean sample size per strain3.5   mice 3.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.0099 0.0099 18.8301 0.0001
strain 4 0.2882 0.072 136.7257 < 0.0001
sex:strain 4 0.008 0.002 3.7833 0.0132
Residuals 30 0.0158 0.0005


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.169 0.0149   4 0.00743 0.0879 0.155, 0.19 -0.64
129S1/SvImJ m 0.17 0.0215   4 0.0108 0.127 0.151, 0.196 -0.35
A/J f 0.2 0.0171   4 0.00857 0.0859 0.175, 0.215 -0.32
A/J m 0.162 0.00732   4 0.00366 0.0453 0.154, 0.168 -0.45
C57BL/6J f 0.176 0.0408   4 0.0204 0.232 0.137, 0.233 -0.56
C57BL/6J m 0.14 0.0128   4 0.00638 0.091 0.13, 0.158 -0.71
NOD/ShiLtJ f 0.319 0.0255   4 0.0128 0.08 0.298, 0.353 0.91
NOD/ShiLtJ m 0.24 0.0245   4 0.0123 0.102 0.215, 0.273 0.47
NZO/HlLtJ f 0.383 0.0257   4 0.0128 0.067 0.348, 0.408 1.56
NZO/HlLtJ m 0.376 0.0224   4 0.0112 0.0596 0.352, 0.403 2.08
PWK/PhJ m 0.14 0.0   1   0.0 0.0 0.14, 0.14 -0.71
WSB/EiJ f 0.138 0.0   1   0.0 0.0 0.138, 0.138 -0.95
WSB/EiJ m 0.172 0.00265   3 0.00153 0.0154 0.17, 0.175 -0.33


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.169 0.0115 0.1924 0.1456
129S1/SvImJ m 0.1703 0.0115 0.1937 0.1468
A/J f 0.1995 0.0115 0.2229 0.1761
A/J m 0.1618 0.0115 0.1852 0.1383
C57BL/6J f 0.176 0.0115 0.1994 0.1526
C57BL/6J m 0.1403 0.0115 0.1637 0.1168
NOD/ShiLtJ f 0.3193 0.0115 0.3427 0.2958
NOD/ShiLtJ m 0.2405 0.0115 0.2639 0.2171
NZO/HlLtJ f 0.3828 0.0115 0.4062 0.3593
NZO/HlLtJ m 0.3763 0.0115 0.3997 0.3528


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.1696 0.0081 0.1862 0.1531
A/J both 0.1806 0.0081 0.1972 0.1641
C57BL/6J both 0.1581 0.0081 0.1747 0.1416
NOD/ShiLtJ both 0.2799 0.0081 0.2964 0.2633
NZO/HlLtJ both 0.3795 0.0081 0.3961 0.3629




  GWAS USING LINEAR MIXED MODELS