Project measure / variable:   GMC20   IgE_21

ID, description, units MPD:56915   IgE_21   immunoglobulin E (plasma IgE)   [ng/mL]  at age 20-21wks  
Data set, strains GMC20   inbred w/CC8   8 strains     sex: both     age: 20-21wks
Procedure immunoglobulin quantification
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  STRAIN COMPARISON PLOT
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GMC20 - immunoglobulin E (plasma IgE) at age 20-21wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means666   ng/mL 257   ng/mL
Median of the strain means98.7   ng/mL 120   ng/mL
SD of the strain means± 1314 ± 371
Coefficient of variation (CV)1.97 1.44
Min–max range of strain means39.7   –   3869   ng/mL 40.2   –   1152   ng/mL
Mean sample size per strain7.2   mice 8.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 4648481.6198 4648481.6198 10.089 0.0019
strain 7 68848027.4524 9835432.4932 21.3468 < 0.0001
sex:strain 7 24042371.5296 3434624.5042 7.4545 < 0.0001
Residuals 108 49760566.3618 460745.9848


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 3869.0 2500.0   7 945.0 0.646 1406.0, 7585.0 2.44
129S1/SvImJ m 1152.0 529.0   8 187.0 0.459 819.0, 2342.0 2.41
A/J f 425.0 506.0   7 191.0 1.19 99.0, 1550.0 -0.18
A/J m 156.0 106.0   9 35.3 0.679 44.7, 328.0 -0.27
C57BL/6J f 89.4 41.8   7 15.8 0.468 26.3, 133.0 -0.44
C57BL/6J m 84.9 61.0   9 20.3 0.718 30.2, 198.0 -0.46
CAST/EiJ f 46.1 40.3   8 14.2 0.874 1.4, 118.0 -0.47
CAST/EiJ m 40.2 16.5   7 6.23 0.41 12.5, 59.0 -0.58
NOD/ShiLtJ f 681.0 1077.0   7 407.0 1.58 85.2, 3072.0 0.01
NOD/ShiLtJ m 196.0 118.0   9 39.3 0.601 66.6, 441.0 -0.16
NZO/HlLtJ f 39.7 62.5   6 25.5 1.58 7.4, 167.0 -0.48
NZO/HlLtJ m 61.6 49.9   7 18.9 0.811 11.7, 134.0 -0.53
PWK/PhJ f 70.4 71.4   7 27.0 1.02 5.2, 193.0 -0.45
PWK/PhJ m 76.7 93.9   8 33.2 1.22 9.0, 296.0 -0.49
WSB/EiJ f 108.0 117.0   9 38.8 1.08 2.0, 349.0 -0.42
WSB/EiJ m 290.0 408.0   9 136.0 1.41 10.3, 1236.0 0.09


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 3868.5286 256.5558 4377.0666 3359.9906
129S1/SvImJ m 1152.05 239.9859 1627.7438 676.3562
A/J f 425.0571 256.5558 933.5952 -83.4809
A/J m 155.8222 226.2609 604.3106 -292.6661
C57BL/6J f 89.3571 256.5558 597.8952 -419.1809
C57BL/6J m 84.9222 226.2609 533.4106 -363.5661
CAST/EiJ f 46.1125 239.9859 521.8063 -429.5813
CAST/EiJ m 40.2 256.5558 548.738 -468.338
NOD/ShiLtJ f 681.3857 256.5558 1189.9237 172.8477
NOD/ShiLtJ m 196.0444 226.2609 644.5328 -252.4439
NZO/HlLtJ f 39.6667 277.1119 588.9505 -509.6172
NZO/HlLtJ m 61.5714 256.5558 570.1094 -446.9666
PWK/PhJ f 70.3571 256.5558 578.8952 -438.1809
PWK/PhJ m 76.7 239.9859 552.3938 -398.9938
WSB/EiJ f 107.8111 226.2609 556.2995 -340.6773
WSB/EiJ m 290.0889 226.2609 738.5773 -158.3995


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 2510.2893 175.6517 2858.4615 2162.1171
A/J both 290.4397 171.0372 629.465 -48.5857
C57BL/6J both 87.1397 171.0372 426.165 -251.8857
CAST/EiJ both 43.1562 175.6517 391.3284 -305.0159
NOD/ShiLtJ both 438.7151 171.0372 777.7404 99.6897
NZO/HlLtJ both 50.619 188.8199 424.8929 -323.6548
PWK/PhJ both 73.5286 175.6517 421.7007 -274.6436
WSB/EiJ both 198.95 159.9906 516.0792 -118.1792




  GWAS USING LINEAR MIXED MODELS