Project measure / variable:   GMC20   IgG3_21

ID, description, units MPD:56913   IgG3_21   immunoglobulin G3 (plasma IgG3)   [µg/mL]  at age 20-21wks  
Data set, strains GMC20   inbred w/CC8   8 strains     sex: both     age: 20-21wks
Procedure immunoglobulin quantification
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  STRAIN COMPARISON PLOT
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GMC20 - immunoglobulin G3 (plasma IgG3) at age 20-21wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means326   µg/mL 387   µg/mL
Median of the strain means300   µg/mL 375   µg/mL
SD of the strain means± 122 ± 147
Coefficient of variation (CV)0.374 0.380
Min–max range of strain means125   –   484   µg/mL 201   –   660   µg/mL
Mean sample size per strain8.1   mice 9.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 132613.4566 132613.4566 1.1863 0.2782
strain 7 1615277.3919 230753.9131 2.0643 0.0523
sex:strain 7 590548.6792 84364.097 0.7547 0.6262
Residuals 123 13749383.8543 111783.6086


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 425.0 224.0   10 70.9 0.528 116.0, 794.0 0.81
129S1/SvImJ m 660.0 362.0   12 105.0 0.549 106.0, 1117.0 1.85
A/J f 292.0 145.0   9 48.4 0.497 135.0, 537.0 -0.28
A/J m 244.0 235.0   11 70.7 0.96 65.8, 732.0 -0.97
C57BL/6J f 457.0 606.0   9 202.0 1.33 49.6, 2004.0 1.07
C57BL/6J m 470.0 351.0   11 106.0 0.748 67.7, 1305.0 0.56
CAST/EiJ f 484.0 178.0   8 63.0 0.368 294.0, 775.0 1.29
CAST/EiJ m 303.0 90.1   9 30.0 0.297 180.0, 403.0 -0.57
NOD/ShiLtJ f 125.0 147.0   4 73.5 1.18 42.2, 345.0 -1.65
NOD/ShiLtJ m 201.0 143.0   6 58.3 0.712 49.8, 438.0 -1.27
NZO/HlLtJ f 290.0 123.0   7 46.3 0.422 139.0, 515.0 -0.3
NZO/HlLtJ m 471.0 753.0   8 266.0 1.6 115.0, 2322.0 0.57
PWK/PhJ f 231.0 192.0   9 64.1 0.831 53.8, 661.0 -0.78
PWK/PhJ m 397.0 425.0   10 134.0 1.07 56.1, 1396.0 0.07
WSB/EiJ f 308.0 161.0   9 53.5 0.521 115.0, 545.0 -0.15
WSB/EiJ m 353.0 233.0   7 87.9 0.66 113.0, 765.0 -0.23


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 424.951 105.7278 634.2326 215.6694
129S1/SvImJ m 659.7292 96.5158 850.7763 468.682
A/J f 292.4967 111.4469 513.0989 71.8945
A/J m 244.2964 100.8075 443.8386 44.7542
C57BL/6J f 456.7022 111.4469 677.3044 236.1
C57BL/6J m 469.6245 100.8075 669.1668 270.0823
CAST/EiJ f 484.1938 118.2072 718.1777 250.2098
CAST/EiJ m 303.1178 111.4469 523.72 82.5156
NOD/ShiLtJ f 125.045 167.1703 455.9483 -205.8583
NOD/ShiLtJ m 200.7867 136.494 470.9681 -69.3948
NZO/HlLtJ f 290.2386 126.3689 540.378 40.0992
NZO/HlLtJ m 471.1575 118.2072 705.1415 237.1735
PWK/PhJ f 231.3144 111.4469 451.9167 10.7122
PWK/PhJ m 397.125 105.7278 606.4066 187.8434
WSB/EiJ f 307.87 111.4469 528.4722 87.2678
WSB/EiJ m 352.7157 126.3689 602.8551 102.5763


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 542.3401 71.578 684.0244 400.6557
A/J both 268.3965 75.1375 417.1265 119.6665
C57BL/6J both 463.1634 75.1375 611.8934 314.4334
CAST/EiJ both 393.6558 81.2302 554.4459 232.8657
NOD/ShiLtJ both 162.9158 107.908 376.513 -50.6813
NZO/HlLtJ both 380.698 86.5188 551.9568 209.4393
PWK/PhJ both 314.2197 76.8094 466.2593 162.1801
WSB/EiJ both 330.2929 84.2459 497.0525 163.5333




  GWAS USING LINEAR MIXED MODELS