Project measure / variable:   GMC20   IgG2b_21

ID, description, units MPD:56911   IgG2b_21   immunoglobulin G2b (plasma IgG2b)   [µg/mL]  at age 20-21wks  
Data set, strains GMC20   inbred w/CC8   8 strains     sex: both     age: 20-21wks
Procedure immunoglobulin quantification
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  STRAIN COMPARISON PLOT
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GMC20 - immunoglobulin G2b (plasma IgG2b) at age 20-21wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains7 strains
Mean of the strain means203   µg/mL 203   µg/mL
Median of the strain means190   µg/mL 185   µg/mL
SD of the strain means± 164 ± 135
Coefficient of variation (CV)0.806 0.665
Min–max range of strain means43.5   –   525   µg/mL 53.1   –   393   µg/mL
Mean sample size per strain3.0   mice 4.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 619.7782 619.7782 0.0932 0.7617
strain 4 912300.3635 228075.0909 34.3095 < 0.0001
sex:strain 4 64551.3099 16137.8275 2.4276 0.0635
Residuals 40 265903.0672 6647.5767


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 270.0 68.0   4 34.0 0.252 203.0, 365.0 0.41
129S1/SvImJ m 359.0 163.0   7 61.5 0.453 170.0, 663.0 1.16
A/J f 116.0 44.5   3 25.7 0.385 67.0, 154.0 -0.53
A/J m 87.2 32.2   4 16.1 0.369 54.7, 126.0 -0.86
C57BL/6J f 275.0 73.6   4 36.8 0.268 204.0, 362.0 0.44
C57BL/6J m 244.0 44.0   6 18.0 0.18 201.0, 316.0 0.3
CAST/EiJ f 82.6 40.8   6 16.6 0.494 44.9, 148.0 -0.74
CAST/EiJ m 99.0 51.6   6 21.1 0.521 48.4, 193.0 -0.77
NOD/ShiLtJ f 525.0 90.4   4 45.2 0.172 427.0, 630.0 1.96
NOD/ShiLtJ m 393.0 52.9   6 21.6 0.135 336.0, 486.0 1.41
NZO/HlLtJ f 50.1 0.0   1   0.0 0.0 50.1, 50.1 -0.94
NZO/HlLtJ m 53.1 10.6   2   7.49 0.2 45.6, 60.5 -1.11
PWK/PhJ f 43.5 0.0   1   0.0 0.0 43.5, 43.5 -0.98
PWK/PhJ m 185.0 0.0   1   0.0 0.0 185.0, 185.0 -0.13
WSB/EiJ f 265.0 0.0   1   0.0 0.0 265.0, 265.0 0.38


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 270.1725 40.7663 352.5643 187.7807
129S1/SvImJ m 359.44 30.8165 421.7224 297.1576
A/J f 115.5967 47.0729 210.7346 20.4588
A/J m 87.2475 40.7663 169.6393 4.8557
C57BL/6J f 274.8825 40.7663 357.2743 192.4907
C57BL/6J m 244.28 33.2856 311.5527 177.0073
CAST/EiJ f 82.5783 33.2856 149.851 15.3057
CAST/EiJ m 99.02 33.2856 166.2927 31.7473
NOD/ShiLtJ f 524.955 40.7663 607.3468 442.5632
NOD/ShiLtJ m 392.6083 33.2856 459.881 325.3357


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 314.8063 25.5517 366.4481 263.1644
A/J both 101.4221 31.1358 164.3499 38.4943
C57BL/6J both 259.5813 26.3146 312.765 206.3975
CAST/EiJ both 90.7992 23.5365 138.3681 43.2302
NOD/ShiLtJ both 458.7817 26.3146 511.9654 405.598




  GWAS USING LINEAR MIXED MODELS