Project measure / variable:   GMC20   IgG2b_17

ID, description, units MPD:56910   IgG2b_17   immunoglobulin G2b (plasma IgG2b)   [µg/mL]  at age 16-17wks  
Data set, strains GMC20   inbred w/CC8   5 strains     sex: both     age: 16-17wks
Procedure immunoglobulin quantification
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  STRAIN COMPARISON PLOT
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GMC20 - immunoglobulin G2b (plasma IgG2b) at age 16-17wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested5 strains4 strains
Mean of the strain means110   µg/mL 133   µg/mL
Median of the strain means82.6   µg/mL 144   µg/mL
SD of the strain means± 66.8 ± 49.1
Coefficient of variation (CV)0.607 0.368
Min–max range of strain means51.4   –   204   µg/mL 64.6   –   181   µg/mL
Mean sample size per strain3.0   mice 3.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 575.6729 575.6729 0.2635 0.6134
strain 3 53098.6704 17699.5568 8.1 0.001
sex:strain 3 8657.6588 2885.8863 1.3207 0.2955
Residuals 20 43702.429 2185.1215


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 82.6 38.3   4 19.2 0.464 51.0, 137.0 -0.41
129S1/SvImJ m 145.0 108.0   4 53.9 0.742 56.6, 300.0 0.24
A/J f 57.1 8.94   2   6.32 0.157 50.8, 63.4 -0.79
A/J m 64.6 7.69   2   5.44 0.119 59.1, 70.0 -1.4
C57BL/6J f 155.0 28.3   4 14.2 0.183 118.0, 186.0 0.67
C57BL/6J m 143.0 10.0   4 5.01 0.07 131.0, 153.0 0.2
NOD/ShiLtJ f 204.0 12.5   4 6.23 0.0611 193.0, 222.0 1.41
NOD/ShiLtJ m 181.0 19.0   4 9.52 0.105 155.0, 200.0 0.97
NZO/HlLtJ f 51.4 0.0   1   0.0 0.0 51.4, 51.4 -0.88


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 82.6175 23.3726 131.372 33.863
129S1/SvImJ m 145.2825 23.3726 194.037 96.528
A/J f 57.105 33.0539 126.0542 -11.8442
A/J m 64.56 33.0539 133.5092 -4.3892
C57BL/6J f 154.9475 23.3726 203.702 106.193
C57BL/6J m 143.17 23.3726 191.9245 94.4155
NOD/ShiLtJ f 203.8575 23.3726 252.612 155.103
NOD/ShiLtJ m 180.9825 23.3726 229.737 132.228


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 113.95 16.527 148.4246 79.4754
A/J both 60.8325 23.3726 109.587 12.078
C57BL/6J both 149.0587 16.527 183.5334 114.5841
NOD/ShiLtJ both 192.42 16.527 226.8946 157.9454




  GWAS USING LINEAR MIXED MODELS