Project measure / variable:   GMC20   IgG1_21

ID, description, units MPD:56907   IgG1_21   immunoglobulin G1 (plasma IgG1)   [µg/mL]  at age 20-21wks  
Data set, strains GMC20   inbred w/CC8   8 strains     sex: both     age: 20-21wks
Procedure immunoglobulin quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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GMC20 - immunoglobulin G1 (plasma IgG1) at age 20-21wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means297   µg/mL 331   µg/mL
Median of the strain means250   µg/mL 258   µg/mL
SD of the strain means± 161 ± 211
Coefficient of variation (CV)0.540 0.636
Min–max range of strain means142   –   618   µg/mL 100   –   710   µg/mL
Mean sample size per strain4.0   mice 4.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 31660.9112 31660.9112 0.4606 0.5013
strain 5 897393.3915 179478.6783 2.6109 0.0391
sex:strain 5 218408.96 43681.792 0.6354 0.6739
Residuals 40 2749724.0317 68743.1008


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 618.0 677.0   5 303.0 1.1 144.0, 1746.0 2.0
129S1/SvImJ m 381.0 219.0   6 89.6 0.576 89.6, 605.0 0.24
A/J f 215.0 212.0   5 94.7 0.987 46.5, 480.0 -0.51
A/J m 258.0 229.0   6 93.4 0.887 39.5, 589.0 -0.35
C57BL/6J f 314.0 139.0   4 69.3 0.441 195.0, 473.0 0.1
C57BL/6J m 481.0 189.0   4 94.3 0.393 239.0, 636.0 0.71
CAST/EiJ f 364.0 107.0   5 47.9 0.294 274.0, 541.0 0.41
NOD/ShiLtJ m 710.0 458.0   3 264.0 0.645 375.0, 1232.0 1.8
NZO/HlLtJ f 142.0 16.0   2   11.3 0.113 130.0, 153.0 -0.97
NZO/HlLtJ m 170.0 75.9   4 38.0 0.446 118.0, 283.0 -0.77
PWK/PhJ f 179.0 72.5   3 41.9 0.404 119.0, 260.0 -0.74
PWK/PhJ m 100.0 34.6   6 14.1 0.345 65.7, 160.0 -1.1
WSB/EiJ f 250.0 96.8   4 48.4 0.388 148.0, 350.0 -0.3
WSB/EiJ m 218.0 56.8   3 32.8 0.261 183.0, 283.0 -0.54


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 618.498 117.2545 855.4782 381.5178
129S1/SvImJ m 381.0783 107.0382 597.4107 164.746
A/J f 214.602 117.2545 451.5822 -22.3782
A/J m 258.0233 107.0382 474.3557 41.691
C57BL/6J f 314.38 131.0945 579.3319 49.4281
C57BL/6J m 480.565 131.0945 745.5169 215.6131
NZO/HlLtJ f 141.67 185.3957 516.3686 -233.0286
NZO/HlLtJ m 170.195 131.0945 435.1469 -94.7569
PWK/PhJ f 179.3233 151.3749 485.2635 -126.6168
PWK/PhJ m 100.2217 107.0382 316.554 -116.1107
WSB/EiJ f 249.825 131.0945 514.7769 -15.1269
WSB/EiJ m 217.8367 151.3749 523.7768 -88.1035


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 499.7882 79.3817 660.2245 339.3518
A/J both 236.3127 79.3817 396.749 75.8763
C57BL/6J both 397.4725 92.6978 584.8218 210.1232
NZO/HlLtJ both 155.9325 113.5312 385.3876 -73.5226
PWK/PhJ both 139.7725 92.6978 327.1218 -47.5768
WSB/EiJ both 233.8308 100.1251 436.1912 31.4705




  GWAS USING LINEAR MIXED MODELS