Project measure / variable:   GMC20   IgG1_17

ID, description, units MPD:56906   IgG1_17   immunoglobulin G1 (plasma IgG1)   [µg/mL]  at age 16-17wks  
Data set, strains GMC20   inbred w/CC8   6 strains     sex: both     age: 16-17wks
Procedure immunoglobulin quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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GMC20 - immunoglobulin G1 (plasma IgG1) at age 16-17wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested5 strains6 strains
Mean of the strain means300   µg/mL 235   µg/mL
Median of the strain means278   µg/mL 232   µg/mL
SD of the strain means± 167 ± 99.0
Coefficient of variation (CV)0.555 0.422
Min–max range of strain means107   –   539   µg/mL 95.2   –   385   µg/mL
Mean sample size per strain3.4   mice 3.2   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 33835.7595 33835.7595 0.7492 0.3953
strain 3 256211.7774 85403.9258 1.891 0.1581
sex:strain 3 68241.3288 22747.1096 0.5037 0.6834
Residuals 24 1083899.6842 45162.4868


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 199.0 79.4   4 39.7 0.398 121.0, 301.0 -0.61
129S1/SvImJ m 286.0 195.0   4 97.3 0.68 94.2, 468.0 0.52
A/J f 278.0 107.0   4 53.3 0.384 178.0, 424.0 -0.13
A/J m 207.0 73.8   4 36.9 0.357 144.0, 314.0 -0.28
C57BL/6J f 378.0 411.0   4 205.0 1.09 36.3, 966.0 0.47
C57BL/6J m 256.0 112.0   4 55.9 0.436 175.0, 417.0 0.22
NOD/ShiLtJ f 539.0 299.0   4 150.0 0.556 276.0, 967.0 1.43
NOD/ShiLtJ m 385.0 171.0   4 85.6 0.445 271.0, 637.0 1.52
NZO/HlLtJ f 107.0 0.0   1   0.0 0.0 107.0, 107.0 -1.16
NZO/HlLtJ m 95.2 1.33   2   0.94 0.014 94.3, 96.2 -1.41
PWK/PhJ m 179.0 0.0   1   0.0 0.0 179.0, 179.0 -0.56


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 199.4875 106.2573 418.7919 -19.8169
129S1/SvImJ m 286.0775 106.2573 505.3819 66.7731
A/J f 277.84 106.2573 497.1444 58.5356
A/J m 206.68 106.2573 425.9844 -12.6244
C57BL/6J f 378.255 106.2573 597.5594 158.9506
C57BL/6J m 256.4125 106.2573 475.7169 37.1081
NOD/ShiLtJ f 538.555 106.2573 757.8594 319.2506
NOD/ShiLtJ m 384.83 106.2573 604.1344 165.5256


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 242.7825 75.1353 397.8541 87.7109
A/J both 242.26 75.1353 397.3316 87.1884
C57BL/6J both 317.3338 75.1353 472.4054 162.2621
NOD/ShiLtJ both 461.6925 75.1353 616.7641 306.6209




  GWAS USING LINEAR MIXED MODELS