Project measure / variable:   GMC20   IgM_21

ID, description, units MPD:56903   IgM_21   immunoglobulin M (plasma IgM)   [µg/mL]  at age 20-21wks  
Data set, strains GMC20   inbred w/CC8   8 strains     sex: both     age: 20-21wks
Procedure immunoglobulin quantification
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  STRAIN COMPARISON PLOT
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GMC20 - immunoglobulin M (plasma IgM) at age 20-21wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means517   µg/mL 545   µg/mL
Median of the strain means432   µg/mL 402   µg/mL
SD of the strain means± 226 ± 358
Coefficient of variation (CV)0.436 0.656
Min–max range of strain means266   –   993   µg/mL 258   –   1374   µg/mL
Mean sample size per strain8.2   mice 9.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 17392.8882 17392.8882 0.2404 0.6248
strain 7 6566820.9352 938117.2765 12.9653 < 0.0001
sex:strain 7 385431.9483 55061.7069 0.761 0.621
Residuals 127 9189218.9218 72356.0545


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 609.0 420.0   10 133.0 0.689 214.0, 1348.0 0.41
129S1/SvImJ m 624.0 329.0   12 95.0 0.528 270.0, 1306.0 0.22
A/J f 266.0 149.0   8 52.7 0.561 85.3, 453.0 -1.11
A/J m 258.0 147.0   10 46.5 0.571 66.8, 499.0 -0.8
C57BL/6J f 423.0 189.0   10 59.9 0.447 64.8, 728.0 -0.42
C57BL/6J m 414.0 228.0   12 65.7 0.55 169.0, 970.0 -0.37
CAST/EiJ f 394.0 110.0   6 44.8 0.278 207.0, 507.0 -0.55
CAST/EiJ m 376.0 135.0   8 47.6 0.359 152.0, 627.0 -0.47
NOD/ShiLtJ f 626.0 259.0   7 97.9 0.414 278.0, 964.0 0.48
NOD/ShiLtJ m 593.0 393.0   9 131.0 0.664 111.0, 1193.0 0.14
NZO/HlLtJ f 993.0 219.0   6 89.3 0.22 620.0, 1284.0 2.11
NZO/HlLtJ m 1374.0 662.0   4 331.0 0.482 543.0, 2141.0 2.32
PWK/PhJ f 441.0 319.0   9 106.0 0.723 46.0, 1097.0 -0.34
PWK/PhJ m 389.0 52.6   11 15.9 0.135 336.0, 489.0 -0.44
WSB/EiJ f 386.0 231.0   10 73.2 0.6 76.9, 764.0 -0.58
WSB/EiJ m 329.0 216.0   11 65.2 0.657 27.6, 684.0 -0.6


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 608.795 85.0624 777.1181 440.4719
129S1/SvImJ m 624.0808 77.651 777.7381 470.4236
A/J f 265.7038 95.1026 453.8947 77.5128
A/J m 257.815 85.0624 426.1381 89.4919
C57BL/6J f 423.216 85.0624 591.5391 254.8929
C57BL/6J m 413.805 77.651 567.4622 260.1478
CAST/EiJ f 394.1283 109.815 611.4325 176.8242
CAST/EiJ m 375.5537 95.1026 563.7447 187.3628
NOD/ShiLtJ f 626.01 101.669 827.1945 424.8255
NOD/ShiLtJ m 592.5256 89.6636 769.9536 415.0975
NZO/HlLtJ f 993.1217 109.815 1210.4258 775.8175
NZO/HlLtJ m 1374.225 134.4954 1640.3671 1108.0829
PWK/PhJ f 440.9989 89.6636 618.427 263.5708
PWK/PhJ m 389.4964 81.1038 549.9861 229.0066
WSB/EiJ f 385.571 85.0624 553.8941 217.2479
WSB/EiJ m 328.8427 81.1038 489.3325 168.353


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 616.4379 57.5875 730.3932 502.4827
A/J both 261.7594 63.7968 388.0017 135.5171
C57BL/6J both 418.5105 57.5875 532.4658 304.5552
CAST/EiJ both 384.841 72.6358 528.5742 241.1079
NOD/ShiLtJ both 609.2678 67.7793 743.3908 475.1448
NZO/HlLtJ both 1183.6733 86.8164 1355.4673 1011.8793
PWK/PhJ both 415.2476 60.4512 534.8696 295.6256
WSB/EiJ both 357.2069 58.7653 473.4927 240.921




  GWAS USING LINEAR MIXED MODELS