Project measure / variable:   GMC16   creatinine_21

ID, description, units MPD:56541   creatinine_21   creatinine (plasma)   [µmol/L]  at age 20-21wks  
Data set, strains GMC16   inbred w/CC8   8 strains     sex: both     age: 20-21wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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GMC16 - creatinine (plasma) at age 20-21wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means12.6   µmol/L 12.2   µmol/L
Median of the strain means12.4   µmol/L 12.9   µmol/L
SD of the strain means± 2.35 ± 1.89
Coefficient of variation (CV)0.187 0.155
Min–max range of strain means9.76   –   16.9   µmol/L 8.98   –   13.8   µmol/L
Mean sample size per strain10.1   mice 11.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 13.285 13.285 0.4224 0.5167
strain 7 275.6682 39.3812 1.252 0.2777
sex:strain 7 430.3571 61.4796 1.9546 0.0645
Residuals 158 4969.6852 31.4537


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 9.76 3.39   10 1.07 0.348 5.3, 16.9 -1.21
129S1/SvImJ m 8.98 3.51   12 1.01 0.391 3.45, 14.5 -1.68
A/J f 14.9 5.61   10 1.77 0.376 6.72, 24.2 0.97
A/J m 12.8 5.44   11 1.64 0.425 6.28, 25.2 0.34
C57BL/6J f 12.4 4.71   10 1.49 0.38 6.01, 20.5 -0.09
C57BL/6J m 13.4 7.49   12 2.16 0.557 4.42, 31.2 0.65
CAST/EiJ f 16.9 5.72   12 1.65 0.339 5.48, 25.3 1.82
CAST/EiJ m 9.32 6.47   11 1.95 0.695 3.98, 21.8 -1.5
NOD/ShiLtJ f 10.2 3.26   9 1.09 0.318 5.83, 16.8 -1.02
NOD/ShiLtJ m 13.8 7.69   12 2.22 0.559 5.48, 30.1 0.87
NZO/HlLtJ f 12.3 5.43   10 1.72 0.443 4.6, 21.5 -0.13
NZO/HlLtJ m 13.0 7.25   12 2.09 0.556 4.33, 28.0 0.44
PWK/PhJ f 11.6 5.87   10 1.86 0.508 4.42, 24.8 -0.43
PWK/PhJ m 13.2 6.56   11 1.98 0.497 3.98, 24.3 0.55
WSB/EiJ f 12.8 3.72   10 1.18 0.291 5.57, 16.1 0.08
WSB/EiJ m 12.8 3.2   12 0.923 0.25 5.3, 15.6 0.34


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 9.757 1.7735 13.2599 6.2541
129S1/SvImJ m 8.98 1.619 12.1777 5.7823
A/J f 14.932 1.7735 18.4349 11.4291
A/J m 12.7936 1.691 16.1335 9.4538
C57BL/6J f 12.403 1.7735 15.9059 8.9001
C57BL/6J m 13.445 1.619 16.6427 10.2473
CAST/EiJ f 16.8625 1.619 20.0602 13.6648
CAST/EiJ m 9.3155 1.691 12.6553 5.9756
NOD/ShiLtJ f 10.2344 1.8695 13.9268 6.5421
NOD/ShiLtJ m 13.7692 1.619 16.9668 10.5715
NZO/HlLtJ f 12.252 1.7735 15.7549 8.7491
NZO/HlLtJ m 13.0458 1.619 16.2435 9.8482
PWK/PhJ f 11.563 1.7735 15.0659 8.0601
PWK/PhJ m 13.1873 1.691 16.5271 9.8474
WSB/EiJ f 12.765 1.7735 16.2679 9.2621
WSB/EiJ m 12.7742 1.619 15.9718 9.5765


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 9.3685 1.2007 11.7399 6.9971
A/J both 13.8628 1.2252 16.2828 11.4429
C57BL/6J both 12.924 1.2007 15.2954 10.5526
CAST/EiJ both 13.089 1.1705 15.4009 10.7771
NOD/ShiLtJ both 12.0018 1.2365 14.4441 9.5596
NZO/HlLtJ both 12.6489 1.2007 15.0204 10.2775
PWK/PhJ both 12.3751 1.2252 14.7951 9.9552
WSB/EiJ both 12.7696 1.2007 15.141 10.3981




  GWAS USING LINEAR MIXED MODELS