Project measure / variable:   GMC16   AST_21

ID, description, units MPD:56531   AST_21   aspartate transaminase (plasma AST)   [IU/L]  at age 20-21wks  
Data set, strains GMC16   inbred w/CC8   8 strains     sex: both     age: 20-21wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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GMC16 - aspartate transaminase (plasma AST) at age 20-21wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means100   IU/L 67.7   IU/L
Median of the strain means74.9   IU/L 66.8   IU/L
SD of the strain means± 55.8 ± 19.3
Coefficient of variation (CV)0.557 0.285
Min–max range of strain means52.0   –   195   IU/L 43.5   –   105   IU/L
Mean sample size per strain8.9   mice 9.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 49809.7037 49809.7037 15.2793 0.0001
strain 7 138643.4369 19806.2053 6.0756 < 0.0001
sex:strain 7 84800.5243 12114.3606 3.7161 0.0011
Residuals 133 433574.1472 3259.956


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 54.6 8.71   9 2.9 0.16 43.0, 70.0 -0.82
129S1/SvImJ m 43.5 2.8   10 0.885 0.0643 39.0, 47.0 -1.25
A/J f 195.0 122.0   10 38.6 0.625 89.0, 475.0 1.7
A/J m 79.1 24.6   11 7.41 0.311 57.0, 128.0 0.59
C57BL/6J f 52.0 11.9   10 3.75 0.228 37.0, 78.0 -0.86
C57BL/6J m 53.5 25.9   12 7.47 0.484 32.0, 119.0 -0.73
CAST/EiJ f 76.5 26.9   10 8.5 0.351 43.0, 130.0 -0.42
CAST/EiJ m 52.4 13.0   7 4.9 0.247 37.0, 74.0 -0.79
NOD/ShiLtJ f 175.0 159.0   9 53.1 0.911 44.0, 525.0 1.34
NOD/ShiLtJ m 74.0 33.2   11 10.0 0.448 39.0, 139.0 0.33
NZO/HlLtJ f 73.3 34.7   6 14.1 0.473 48.0, 139.0 -0.48
NZO/HlLtJ m 105.0 81.6   6 33.3 0.778 38.0, 247.0 1.94
PWK/PhJ f 62.9 20.0   7 7.54 0.318 45.0, 92.0 -0.67
PWK/PhJ m 63.4 16.7   9 5.58 0.264 46.0, 102.0 -0.22
WSB/EiJ f 112.0 41.6   10 13.2 0.37 75.0, 212.0 0.21
WSB/EiJ m 70.3 17.1   12 4.92 0.243 51.0, 96.0 0.14


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 54.5556 19.032 92.2001 16.911
129S1/SvImJ m 43.5 18.0553 79.2128 7.7872
A/J f 195.3 18.0553 231.0128 159.5872
A/J m 79.0909 17.2151 113.1417 45.0401
C57BL/6J f 52.0 18.0553 87.7128 16.2872
C57BL/6J m 53.5 16.4822 86.1012 20.8988
CAST/EiJ f 76.5 18.0553 112.2128 40.7872
CAST/EiJ m 52.4286 21.5803 95.1135 9.7436
NOD/ShiLtJ f 174.8889 19.032 212.5335 137.2443
NOD/ShiLtJ m 74.0 17.2151 108.0508 39.9492
NZO/HlLtJ f 73.3333 23.3094 119.4383 27.2283
NZO/HlLtJ m 104.8333 23.3094 150.9383 58.7283
PWK/PhJ f 62.8571 21.5803 105.5421 20.1722
PWK/PhJ m 63.4444 19.032 101.089 25.7999
WSB/EiJ f 112.4 18.0553 148.1128 76.6872
WSB/EiJ m 70.3333 16.4822 102.9345 37.7322


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 49.0278 13.1169 74.9725 23.083
A/J both 137.1955 12.4735 161.8676 112.5233
C57BL/6J both 52.75 12.2235 76.9277 28.5723
CAST/EiJ both 64.4643 14.0686 92.2915 36.6371
NOD/ShiLtJ both 124.4444 12.8314 149.8244 99.0645
NZO/HlLtJ both 89.0833 16.4822 121.6845 56.4822
PWK/PhJ both 63.1508 14.3868 91.6074 34.6942
WSB/EiJ both 91.3667 12.2235 115.5443 67.189




  GWAS USING LINEAR MIXED MODELS