Project measure / variable:   GMC16   AST_17

ID, description, units MPD:56530   AST_17   aspartate transaminase (plasma AST)   [IU/L]  at age 16-17wks  
Data set, strains GMC16   inbred w/CC8   7 strains     sex: both     age: 16-17wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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GMC16 - aspartate transaminase (plasma AST) at age 16-17wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested6 strains7 strains
Mean of the strain means66.6   IU/L 71.9   IU/L
Median of the strain means64.1   IU/L 84.3   IU/L
SD of the strain means± 17.6 ± 24.5
Coefficient of variation (CV)0.264 0.341
Min–max range of strain means47.5   –   93.8   IU/L 45.0   –   98.0   IU/L
Mean sample size per strain3.3   mice 3.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 871.6842 871.6842 1.9644 0.172
strain 4 10847.8123 2711.9531 6.1116 0.0012
sex:strain 4 4786.1526 1196.5381 2.6965 0.0511
Residuals 28 12424.6667 443.7381


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 52.2 4.99   4 2.5 0.0955 47.0, 57.0 -0.82
129S1/SvImJ m 46.5 8.43   4 4.21 0.181 41.0, 59.0 -1.04
A/J f 93.8 7.54   4 3.77 0.0805 89.0, 105.0 1.55
A/J m 90.0 28.6   4 14.3 0.318 60.0, 125.0 0.74
C57BL/6J f 57.5 21.1   4 10.6 0.368 41.0, 88.0 -0.52
C57BL/6J m 46.8 6.9   4 3.45 0.148 38.0, 54.0 -1.03
NOD/ShiLtJ f 70.7 17.6   3 10.1 0.248 54.0, 89.0 0.23
NOD/ShiLtJ m 92.8 21.6   4 10.8 0.233 71.0, 118.0 0.85
NZO/HlLtJ f 47.5 8.43   4 4.21 0.177 42.0, 60.0 -1.09
NZO/HlLtJ m 98.0 53.8   3 31.1 0.549 63.0, 160.0 1.07
PWK/PhJ m 45.0 0.0   1   0.0 0.0 45.0, 45.0 -1.1
WSB/EiJ f 78.0 0.0   1   0.0 0.0 78.0, 78.0 0.65
WSB/EiJ m 84.3 24.0   3 13.9 0.285 69.0, 112.0 0.51


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 52.25 10.5325 73.8249 30.6751
129S1/SvImJ m 46.5 10.5325 68.0749 24.9251
A/J f 93.75 10.5325 115.3249 72.1751
A/J m 90.0 10.5325 111.5749 68.4251
C57BL/6J f 57.5 10.5325 79.0749 35.9251
C57BL/6J m 46.75 10.5325 68.3249 25.1751
NOD/ShiLtJ f 70.6667 12.1619 95.5793 45.7541
NOD/ShiLtJ m 92.75 10.5325 114.3249 71.1751
NZO/HlLtJ f 47.5 10.5325 69.0749 25.9251
NZO/HlLtJ m 98.0 12.1619 122.9126 73.0874


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 49.375 7.4476 64.6308 34.1192
A/J both 91.875 7.4476 107.1308 76.6192
C57BL/6J both 52.125 7.4476 67.3808 36.8692
NOD/ShiLtJ both 81.7083 8.0444 98.1865 65.2302
NZO/HlLtJ both 72.75 8.0444 89.2281 56.2719




  GWAS USING LINEAR MIXED MODELS