Project measure / variable:   GMC16   ALT_21

ID, description, units MPD:56529   ALT_21   alanine transaminase (plasma ALT)   [IU/L]  at age 20-21wks  
Data set, strains GMC16   inbred w/CC8   8 strains     sex: both     age: 20-21wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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GMC16 - alanine transaminase (plasma ALT) at age 20-21wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means48.1   IU/L 42.0   IU/L
Median of the strain means40.0   IU/L 43.4   IU/L
SD of the strain means± 20.3 ± 6.88
Coefficient of variation (CV)0.421 0.164
Min–max range of strain means32.2   –   90.3   IU/L 30.7   –   53.8   IU/L
Mean sample size per strain10.1   mice 11.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1319.4018 1319.4018 1.636 0.2027
strain 7 13734.3406 1962.0487 2.4329 0.0215
sex:strain 7 18770.2849 2681.4693 3.325 0.0025
Residuals 158 127420.6394 806.4597


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 42.3 15.6   10 4.94 0.369 16.0, 63.0 -0.29
129S1/SvImJ m 44.1 20.0   12 5.76 0.453 18.0, 92.0 0.3
A/J f 90.3 45.8   10 14.5 0.507 43.0, 176.0 2.08
A/J m 43.4 24.5   11 7.38 0.565 21.0, 108.0 0.2
C57BL/6J f 33.7 19.6   10 6.19 0.581 16.0, 82.0 -0.71
C57BL/6J m 44.0 27.5   12 7.94 0.625 17.0, 115.0 0.29
CAST/EiJ f 37.6 21.3   12 6.14 0.566 12.0, 87.0 -0.52
CAST/EiJ m 30.7 8.87   11 2.67 0.289 14.0, 46.0 -1.64
NOD/ShiLtJ f 65.7 69.4   9 23.1 1.06 19.0, 224.0 0.87
NOD/ShiLtJ m 34.8 14.2   12 4.09 0.408 20.0, 55.0 -1.05
NZO/HlLtJ f 34.6 8.76   10 2.77 0.253 19.0, 47.0 -0.67
NZO/HlLtJ m 53.8 44.5   12 12.8 0.827 15.0, 176.0 1.71
PWK/PhJ f 32.2 8.08   10 2.56 0.251 25.0, 46.0 -0.78
PWK/PhJ m 43.4 26.5   11 7.98 0.61 21.0, 116.0 0.2
WSB/EiJ f 48.4 17.2   10 5.43 0.355 21.0, 82.0 0.01
WSB/EiJ m 41.9 21.4   12 6.18 0.51 24.0, 86.0 -0.02


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 42.3 8.9803 60.0369 24.5631
129S1/SvImJ m 44.0833 8.1979 60.2749 27.8918
A/J f 90.3 8.9803 108.0369 72.5631
A/J m 43.3636 8.5624 60.2751 26.4521
C57BL/6J f 33.7 8.9803 51.4369 15.9631
C57BL/6J m 44.0 8.1979 60.1915 27.8085
CAST/EiJ f 37.5833 8.1979 53.7749 21.3918
CAST/EiJ m 30.7273 8.5624 47.6388 13.8158
NOD/ShiLtJ f 65.6667 9.4661 84.363 46.9703
NOD/ShiLtJ m 34.75 8.1979 50.9415 18.5585
NZO/HlLtJ f 34.6 8.9803 52.3369 16.8631
NZO/HlLtJ m 53.8333 8.1979 70.0249 37.6418
PWK/PhJ f 32.2 8.9803 49.9369 14.4631
PWK/PhJ m 43.3636 8.5624 60.2751 26.4521
WSB/EiJ f 48.4 8.9803 66.1369 30.6631
WSB/EiJ m 41.9167 8.1979 58.1082 25.7251


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 43.1917 6.0797 55.1996 31.1837
A/J both 66.8318 6.204 79.0854 54.5783
C57BL/6J both 38.85 6.0797 50.858 26.842
CAST/EiJ both 34.1553 5.927 45.8618 22.4488
NOD/ShiLtJ both 50.2083 6.2612 62.5748 37.8418
NZO/HlLtJ both 44.2167 6.0797 56.2246 32.2087
PWK/PhJ both 37.7818 6.204 50.0354 25.5283
WSB/EiJ both 45.1583 6.0797 57.1663 33.1504




  GWAS USING LINEAR MIXED MODELS