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Project measure / variable:   GMC16   ALT_17

ID, description, units MPD:56528   ALT_17   alanine transaminase (plasma ALT)   [IU/L]  at age 16-17wks  
Data set, strains GMC16   inbred w/CC8   7 strains     sex: both     age: 16-17wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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GMC16 - alanine transaminase (plasma ALT) at age 16-17wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested6 strains7 strains
Mean of the strain means35.1   IU/L 40.4   IU/L
Median of the strain means34.9   IU/L 32.5   IU/L
SD of the strain means± 4.01 ± 15.9
Coefficient of variation (CV)0.114 0.393
Min–max range of strain means30.7   –   39.5   IU/L 27.0   –   65.0   IU/L
Mean sample size per strain3.3   mice 3.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 17.7895 17.7895 0.116 0.736
strain 4 1205.2004 301.3001 1.964 0.1275
sex:strain 4 1846.6461 461.6615 3.0094 0.0349
Residuals 28 4295.4167 153.4077


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 39.5 14.8   4 7.42 0.376 27.0, 58.0 1.11
129S1/SvImJ m 32.5 12.4   4 6.2 0.381 21.0, 46.0 -0.5
A/J f 39.5 6.56   4 3.28 0.166 32.0, 45.0 1.11
A/J m 37.0 6.06   4 3.03 0.164 29.0, 43.0 -0.21
C57BL/6J f 36.5 22.1   4 11.1 0.606 22.0, 69.0 0.36
C57BL/6J m 31.5 5.0   4 2.5 0.159 26.0, 38.0 -0.56
NOD/ShiLtJ f 30.7 8.96   3 5.17 0.292 25.0, 41.0 -1.09
NOD/ShiLtJ m 28.5 3.7   4 1.85 0.13 25.0, 33.0 -0.75
NZO/HlLtJ f 33.2 12.3   4 6.16 0.37 24.0, 51.0 -0.47
NZO/HlLtJ m 65.0 19.2   3 11.1 0.295 52.0, 87.0 1.55
PWK/PhJ m 27.0 0.0   1   0.0 0.0 27.0, 27.0 -0.84
WSB/EiJ f 31.0 0.0   1   0.0 0.0 31.0, 31.0 -1.01
WSB/EiJ m 61.3 42.7   3 24.7 0.697 30.0, 110.0 1.31


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 39.5 6.1929 52.1856 26.8144
129S1/SvImJ m 32.5 6.1929 45.1856 19.8144
A/J f 39.5 6.1929 52.1856 26.8144
A/J m 37.0 6.1929 49.6856 24.3144
C57BL/6J f 36.5 6.1929 49.1856 23.8144
C57BL/6J m 31.5 6.1929 44.1856 18.8144
NOD/ShiLtJ f 30.6667 7.1509 45.3147 16.0186
NOD/ShiLtJ m 28.5 6.1929 41.1856 15.8144
NZO/HlLtJ f 33.25 6.1929 45.9356 20.5644
NZO/HlLtJ m 65.0 7.1509 79.648 50.352


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 36.0 4.379 44.9701 27.0299
A/J both 38.25 4.379 47.2201 29.2799
C57BL/6J both 34.0 4.379 42.9701 25.0299
NOD/ShiLtJ both 29.5833 4.7299 39.2721 19.8946
NZO/HlLtJ both 49.125 4.7299 58.8138 39.4362




  GWAS USING LINEAR MIXED MODELS