Project measure / variable:   GMC16   ALP_21

ID, description, units MPD:56527   ALP_21   alkaline phosphatase (plasma ALP)   [IU/L]  at age 20-21wks  
Data set, strains GMC16   inbred w/CC8   8 strains     sex: both     age: 20-21wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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GMC16 - alkaline phosphatase (plasma ALP) at age 20-21wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means117   IU/L 96.3   IU/L
Median of the strain means125   IU/L 89.3   IU/L
SD of the strain means± 29.8 ± 25.9
Coefficient of variation (CV)0.254 0.269
Min–max range of strain means54.9   –   144   IU/L 68.3   –   135   IU/L
Mean sample size per strain10.1   mice 11.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 19323.9573 19323.9573 11.6918 0.0008
strain 7 81563.804 11651.972 7.0499 < 0.0001
sex:strain 7 34408.8973 4915.5568 2.9741 0.0059
Residuals 158 261138.7667 1652.777


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 137.0 43.6   10 13.8 0.319 76.0, 210.0 0.66
129S1/SvImJ m 73.5 20.1   12 5.81 0.274 51.0, 128.0 -0.88
A/J f 98.7 14.6   10 4.63 0.148 80.0, 122.0 -0.62
A/J m 85.9 11.7   11 3.52 0.136 72.0, 113.0 -0.4
C57BL/6J f 111.0 16.2   10 5.11 0.146 84.0, 131.0 -0.21
C57BL/6J m 68.3 7.38   12 2.13 0.108 58.0, 84.0 -1.08
CAST/EiJ f 118.0 14.5   12 4.18 0.123 95.0, 140.0 0.03
CAST/EiJ m 135.0 19.6   11 5.9 0.145 106.0, 167.0 1.49
NOD/ShiLtJ f 144.0 110.0   9 36.7 0.764 42.0, 334.0 0.9
NOD/ShiLtJ m 92.8 80.6   12 23.3 0.869 39.0, 301.0 -0.14
NZO/HlLtJ f 54.9 6.81   10 2.15 0.124 46.0, 65.0 -2.09
NZO/HlLtJ m 73.1 56.9   12 16.4 0.778 33.0, 241.0 -0.9
PWK/PhJ f 142.0 32.5   10 10.3 0.229 102.0, 207.0 0.83
PWK/PhJ m 125.0 25.5   11 7.68 0.203 75.0, 154.0 1.11
WSB/EiJ f 132.0 22.1   10 6.99 0.167 100.0, 163.0 0.5
WSB/EiJ m 117.0 13.7   12 3.96 0.117 92.0, 142.0 0.8


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 136.9 12.856 162.2919 111.5081
129S1/SvImJ m 73.5 11.7359 96.6795 50.3205
A/J f 98.7 12.856 124.0919 73.3081
A/J m 85.9091 12.2578 110.1193 61.6989
C57BL/6J f 110.7 12.856 136.0919 85.3081
C57BL/6J m 68.3333 11.7359 91.5128 45.1538
CAST/EiJ f 118.0 11.7359 141.1795 94.8205
CAST/EiJ m 135.0909 12.2578 159.3011 110.8807
NOD/ShiLtJ f 144.3333 13.5515 171.0987 117.568
NOD/ShiLtJ m 92.8333 11.7359 116.0128 69.6538
NZO/HlLtJ f 54.9 12.856 80.2919 29.5081
NZO/HlLtJ m 73.0833 11.7359 96.2628 49.9038
PWK/PhJ f 142.2 12.856 167.5919 116.8081
PWK/PhJ m 125.2727 12.2578 149.4829 101.0625
WSB/EiJ f 132.0 12.856 157.3919 106.6081
WSB/EiJ m 117.0833 11.7359 140.2628 93.9038


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 105.2 8.7036 122.3904 88.0096
A/J both 92.3045 8.8816 109.8465 74.7626
C57BL/6J both 89.5167 8.7036 106.707 72.3263
CAST/EiJ both 126.5455 8.485 143.3042 109.7867
NOD/ShiLtJ both 118.5833 8.9634 136.287 100.8797
NZO/HlLtJ both 63.9917 8.7036 81.182 46.8013
PWK/PhJ both 133.7364 8.8816 151.2783 116.1944
WSB/EiJ both 124.5417 8.7036 141.732 107.3513




  GWAS USING LINEAR MIXED MODELS